公开(公告)号：US20240043425A1

公开(公告)日：2024-02-08

申请号：US18319585

申请日：2023-05-18

Applicant: NOVARTIS AG

Inventor： Mallesh BUSHABOINA ,  Xin CHEN ,  Atwood Kim CHEUNG ,  Andrew James CULSHAW ,  Timothy Brian HURLEY ,  Nancy LABBE-GIGUERE ,  Wolfgang MILTZ ,  David ORAIN ,  Tajesh PATEL ,  Srinivasan RAJAGOPALAN ,  Till ROEHN ,  David Andrew SANDHAM ,  Gebhard THOMA ,  Ritesh Bhanudasji TICHKULE ,  Rudolf WÄLCHLI

IPC: C07D471/10 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D471/10 ,  C07D519/00 ,  A61K45/06

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;






wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20210052554A1

公开(公告)日：2021-02-25

申请号：US17089064

申请日：2020-11-04

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef Troxler ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20180021345A1

公开(公告)日：2018-01-25

申请号：US15673155

申请日：2017-08-09

Applicant: Novartis AG

Inventor： David BEATTIE ,  Urs BAETTIG ,  Darren Mark LE GRAND ,  Andrew Stuart LISTER ,  Jeffrey MCKENNA ,  David William PEARCE ,  David Andrew SANDHAM ,  Oliver Ross STEWARD ,  Christopher THOMSON

IPC: A61K31/551 ,  C07D401/12 ,  A61K31/445 ,  C07D413/12 ,  A61K31/5513 ,  A61K45/06 ,  A61K31/504 ,  C07D401/10 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/439 ,  C07D405/12 ,  C07D417/10 ,  C07D417/14 ,  A61K31/4545 ,  C07D403/10 ,  C07D413/14 ,  A61K31/4245 ,  C07D471/08 ,  C07D403/12 ,  A61K31/427 ,  C07D413/10 ,  C07D401/14 ,  A61K31/506 ,  C07D407/12 ,  C07D257/04 ,  C07D403/14 ,  A61K31/45 ,  A61K31/496 ,  A61K31/41

CPC classification number: A61K31/551 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/504 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D257/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/08 ,  A61K2300/00

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

公开(公告)号：US20250092042A1

公开(公告)日：2025-03-20

申请号：US18924066

申请日：2024-10-23

Applicant: NOVARTIS AG

Inventor： Mallesh BUSHABOINA ,  Xin CHEN ,  Atwood Kim CHEUNG ,  Andrew James CULSHAW ,  Timothy Brian HURLEY ,  Nancy LABBE-GIGUERE ,  Wolfgang MILTZ ,  David ORAIN ,  Tajesh PATEL ,  Srinivasan RAJAGOPALAN ,  Till ROEHN ,  David Andrew SANDHAM ,  Gebhard THOMA ,  Ritesh Bhanudasji TICHKULE ,  Rudolf WÄLCHLI

IPC: C07D471/10 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides a method for manufacturing a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein.

公开(公告)号：US20190381011A1

公开(公告)日：2019-12-19

申请号：US16230033

申请日：2018-12-21

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef Troxler ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20230301970A1

公开(公告)日：2023-09-28

申请号：US18317990

申请日：2023-05-16

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef TROXLER-SCHWAB ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

CPC classification number: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof;




a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20200268718A1

公开(公告)日：2020-08-27

申请号：US16874595

申请日：2020-05-14

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef TROXLER ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170014388A1

公开(公告)日：2017-01-19

申请号：US15184730

申请日：2016-06-16

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef Troxler ,  Joe WRIGGLESWORTH

IPC: A61K31/422

CPC classification number: A61K31/422 ,  A61K31/4155 ,  C07D413/12 ,  C07D413/14 ,  A61K2300/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。