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公开(公告)号：US11833215B2
公开(公告)日：2023-12-05
申请号：US16893359
申请日：2020-06-04
Applicant: Novartis AG
Inventor： Tinya Abrams , Steven Bruce Cohen , Dylan Daniel , Catrin Finner , Bernhard Hubert Geierstanger , Thomas Huber , William Mallet , Matthew John Meyer , Weijia Ou , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette
CPC classification number: A61K47/6803 , A61K39/39558 , A61K47/6849 , A61K49/00 , A61K51/103 , A61K51/1093 , A61P35/02 , C07K16/2803 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/77 , C07K2317/92
Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：US10787480B2
公开(公告)日：2020-09-29
申请号：US16439204
申请日：2019-06-12
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US10280139B2
公开(公告)日：2019-05-07
申请号：US15822930
申请日：2017-11-27
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Shifeng Pan , Tetsuo Uno , Yongqin Wan , Xing Wang
IPC: C07D207/09 , C07K5/02 , A61K47/68 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07K16/32
Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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Patent Agency Ranking
公开(公告)号：US20230270876A1
公开(公告)日：2023-08-31
申请号：US18178886
申请日：2023-03-06
Applicant: Novartis AG
Inventor： Bernhard Hubert Geierstanger , Weijia Ou , Tetsuo Uno
CPC classification number: A61K47/6817 , C07K16/32 , A61K47/6855 , A61K47/6871 , A61K47/6803 , C07K16/2863
Abstract: The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.
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公开(公告)号：US11596695B2
公开(公告)日：2023-03-07
申请号：US16701576
申请日：2019-12-03
Applicant: Novartis AG
Inventor： Bernhard Hubert Geierstanger , Weijia Ou , Tetsuo Uno
Abstract: The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.
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公开(公告)号：US10786578B2
公开(公告)日：2020-09-29
申请号：US15329818
申请日：2015-07-27
Applicant: Novartis AG
Inventor： Tinya Abrams , Steven Bruce Cohen , Dylan Daniel , Catrin Finner , Bernhard Hubert Geierstanger , Thomas Huber , William Mallet , Matthew John Meyer , Weijia Ou , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette
Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：US10392421B2
公开(公告)日：2019-08-27
申请号：US15961531
申请日：2018-04-24
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US09938323B2
公开(公告)日：2018-04-10
申请号：US15524197
申请日：2015-11-05
Applicant: NOVARTIS AG
Inventor： Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno
CPC classification number: C07K7/64 , C07K16/22 , C07K16/30 , C07K2319/30
Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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