公开(公告)号：US11891401B2

公开(公告)日：2024-02-06

申请号：US17281528

申请日：2019-10-08

Applicant: NOVARTIS AG

Inventor： Yudong Cao ,  Siyi Jiang ,  Hongyong Kim ,  Andreas Kordikowski ,  Irene Xia ,  Bo Yu ,  Jing Zhang ,  Yi Zhao

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07C57/15 ,  A61P33/02

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P33/02 ,  C07C57/15 ,  C07B2200/13

Abstract: The application relates to N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide (Compound I) fumaric acid co-crystals and X-ray amorphous complexes of Compound (I) and fumaric acid. The application also provides methods of making the same; pharmaceutical compositions comprising them; and their use in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a kinetoplastid parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US11208398B2

公开(公告)日：2021-12-28

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11578053B2

公开(公告)日：2023-02-14

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.