公开(公告)号：US10660888B2

公开(公告)日：2020-05-26

申请号：US16210968

申请日：2018-12-05

Applicant: Novartis AG

Inventor： Jeffrey T. Bagdanoff ,  Yu Ding ,  Wooseok Han ,  Zilin Huang ,  Qun Jiang ,  Xianming Jin ,  Xiang Kou ,  Patrick Lee ,  Mika Lindvall ,  Zhongcheng Min ,  Yue Pan ,  Sabina Pecchi ,  Keith Bruce Pfister ,  Daniel Poon ,  Vivek Rauniyar ,  Xiaojing Michael Wang ,  Qiong Zhang ,  Jianguang Zhou ,  Shejin Zhu

IPC: A61K31/497 ,  C07D213/73 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/5355

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US20240246991A1

公开(公告)日：2024-07-25

申请号：US18531320

申请日：2023-12-06

Applicant: Novartis AG

Inventor： Zhongbo Fei ,  Huanqing Jia ,  Wei Li ,  Xiaohui Lin ,  Zhongcheng Min ,  Hui Wang ,  Jianhua Wang ,  Hao Zhang

IPC: C07D491/107

CPC classification number: C07D491/107

Abstract: The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme:




wherein LG, A, n, m and p are as defined in the Summary of the Invention.

公开(公告)号：US11578053B2

公开(公告)日：2023-02-14

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11208398B2

公开(公告)日：2021-12-28

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11873307B2

公开(公告)日：2024-01-16

申请号：US17280632

申请日：2019-09-18

Applicant: Novartis AG

Inventor： Zhongbo Fei ,  Huanqing Jia ,  Wei Li ,  Xiaohui Lin ,  Zhongcheng Min ,  Hui Wang ,  Jianhua Wang ,  Hao Zhang

IPC: C07D491/107

CPC classification number: C07D491/107

Abstract: The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

公开(公告)号：US20210355134A1

公开(公告)日：2021-11-18

申请号：US17280632

申请日：2019-09-18

Applicant: Novartis AG

Inventor： Zhongbo Fei ,  Huanqing Jia ,  Wei Li ,  Xiaohui Lin ,  Zhongcheng Min ,  Hui Wang ,  Jianhua Wang ,  Hao Zhang

IPC: C07D491/107

Abstract: The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

公开(公告)号：US10188649B2

公开(公告)日：2019-01-29

申请号：US15672568

申请日：2017-08-09

Applicant: Novartis AG

Inventor： Jeffrey T. Bagdanoff ,  Yu Ding ,  Wooseok Han ,  Zilin Huang ,  Qun Jiang ,  Xianming Jin ,  Xiang Kou ,  Patrick Lee ,  Mika Lindvall ,  Zhongcheng Min ,  Yue Pan ,  Sabina Pecchi ,  Keith Bruce Pfister ,  Daniel Poon ,  Vivek Rauniyar ,  Xiaojing Michael Wang ,  Qiong Zhang ,  Jianguang Zhou ,  Shejin Zhu

IPC: C07D241/20 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04 ,  C07D213/73 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/5355

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.