公开(公告)号：US20250067755A1

公开(公告)日：2025-02-27

申请号：US18776405

申请日：2024-07-18

Applicant: Neuracle Science Co., Ltd.

Inventor： Jae Young SEONG ,  Byung Joo HAM ,  Min-Hyeok LEE ,  Nui HA

IPC: G01N33/68 ,  C07K16/24 ,  C12Q1/6883

Abstract: The present disclosure relates to a method of diagnosing a mood disorder in a subject comprising measuring serum FAM19A5 concentration with an antagonist (e.g., an antibody or antigen-binding fragment thereof) that specifically binds to FAM19A5. The present disclosure also relates to a method of treating a mood disorder in a subject in need thereof comprising administering to the subject an FAM19A5 antagonist.

公开(公告)号：US20240238445A1

公开(公告)日：2024-07-18

申请号：US18552290

申请日：2022-07-08

Applicant: NEURACLE SCIENCE CO., LTD. ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS

Inventor： Jae Young SEONG ,  Youngjoo BYUN ,  Hoyun KWAK ,  Sitaek OH ,  Min-Hyeok LEE ,  Yongwoo JEONG ,  Nui HA ,  Eun-Ho CHO ,  Suhyun LEE ,  Sang-Myeong LEE ,  Yerim LEE ,  Eun Bee CHO ,  Jae Keun LEE ,  Han-Byul KIM ,  Soon-gu KWON

IPC: A61K48/00 ,  A61K31/055 ,  A61K31/085 ,  A61K31/136 ,  A61K31/137 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K45/06 ,  A61K47/64 ,  A61P25/02 ,  A61P25/28 ,  C12N5/0793

CPC classification number: A61K48/005 ,  A61K31/055 ,  A61K31/085 ,  A61K31/136 ,  A61K31/137 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/64 ,  A61P25/02 ,  A61P25/28 ,  C12N5/0619

Abstract: The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.

公开(公告)号：US20240175880A1

公开(公告)日：2024-05-30

申请号：US18552293

申请日：2022-11-23

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Jae Young SEONG ,  Hoyun KWAK ,  Sitaek OH ,  Min-Hyeok LEE

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2800/28 ,  G01N2800/52

Abstract: The present disclosure relates to the use of LRRC4 family mimic molecules to determine the expression level of FAM19A5 protein in a subject. In some aspects, such mimic molecules can be used to identify and/or diagnose a subject suffering from or at risk of developing a disease or disorder associated with increased FAM19A5 protein expression. The present disclosure also provides methods of treating subjects identified and/or diagnosed using the methods provided herein.

公开(公告)号：US20200300870A1

公开(公告)日：2020-09-24

申请号：US16753295

申请日：2018-10-02

Applicant: Neuracle Science Co., Ltd. ,  Korea University Research and Business Foundation

Inventor： Jae Young SEONG ,  Byung Joo HAM ,  Min-Hyeok LEE ,  Nui HA

IPC: G01N33/68 ,  C12Q1/6883

Abstract: The present disclosure relates to a method of diagnosing a mood disorder in a subject comprising measuring serum FAM19A5 concentration with an antagonist (e.g., an antibody or antigen-binding fragment thereof) that specifically binds to FAM19A5. The present disclosure also relates to a method of treating a mood disorder in a subject in need thereof comprising administering to the subject an FAM19A5 antagonist.