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公开(公告)号：US07402683B2
公开(公告)日：2008-07-22
申请号：US10512724
申请日：2003-04-14
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
IPC分类号： C07D207/00 , C07D215/38 , C07D213/00 , C07D403/02 , C07D231/00 , A01N43/36 , A01N43/56 , A01N43/40 , A01N43/42
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在人或动物，特别是细菌感染疾病的治疗和/或预防中的用途。
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公开(公告)号：US20060178369A1
公开(公告)日：2006-08-10
申请号：US10512724
申请日：2003-04-14
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/4178 , A61K31/4025
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
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3.发明授权公开(公告)号：US07544709B2
公开(公告)日：2009-06-09
申请号：US10496058
申请日：2002-11-07
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada
IPC分类号： A61K31/4015 , C07D207/40
CPC分类号： C07D207/40
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, particularly bacterial infections diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法，含有它们的药物组合物，以及它们在人或动物疾病，特别是细菌感染疾病的治疗和/或前体中的应用。 这些化合物是天然物质和杀虫剂和莫拉滨B的衍生物。
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公开(公告)号：US07348357B2
公开(公告)日：2008-03-25
申请号：US10524080
申请日：2003-07-28
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/4015 , C07D207/12
CPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在治疗和/或预防人或动物特别是细菌感染疾病中的用途。
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公开(公告)号：US20060173040A1
公开(公告)日：2006-08-03
申请号：US10524080
申请日：2003-07-28
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/422 , C07D409/02 , C07D405/02 , C07D403/02
CPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在治疗和/或预防人或动物特别是细菌感染疾病中的用途。
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公开(公告)号：US20090149528A1
公开(公告)日：2009-06-11
申请号：US12217248
申请日：2008-07-02
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Joseph Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Joseph Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
IPC分类号： A61K31/4025 , C07D207/333 , A61P31/04
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在人或动物尤其是细菌感染疾病的治疗和/或预防中的用途。
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公开(公告)号：US20060258571A1
公开(公告)日：2006-11-16
申请号：US10522667
申请日：2003-07-18
申请人： Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Hein-Peter Kroll , Franz Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Cancho-Grande , Martin Michels , Stefan Weigand
发明人： Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Hein-Peter Kroll , Franz Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Cancho-Grande , Martin Michels , Stefan Weigand
IPC分类号： A61K38/12 , A61K31/395 , C07K5/12
CPC分类号： C07K5/0812 , A61K38/00
摘要： The invention relates to antibacterial ester macrocycles of formula (I), methods for the production thereof, and the use thereof for producing medicaments used for the treatment and/or prophylaxis of diseases, particularly bacterial infections.
摘要翻译： 本发明涉及式（I）的抗菌酯大环化合物，其制备方法及其用于制备用于治疗和/或预防疾病，特别是细菌感染的药物的用途。
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公开(公告)号：US20070129288A1
公开(公告)日：2007-06-07
申请号：US10518600
申请日：2003-06-10
申请人： Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Heinz-Peter Kroll , Franz Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Canco-Grande , Martin Michels , Stefan Weigand
发明人： Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Heinz-Peter Kroll , Franz Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Canco-Grande , Martin Michels , Stefan Weigand
CPC分类号： C07D245/04 , A61K38/00 , C07K5/0812
摘要： The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.
摘要翻译： 本发明涉及抗菌酰胺大环化合物，其生产方法及其用于制备用于治疗和/或预防疾病，特别是细菌感染的药物的用途。
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公开(公告)号：US20050256037A1
公开(公告)日：2005-11-17
申请号：US10957489
申请日：2004-10-01
申请人： Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Hein-Peter Kroll , Franz Von Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Cancho-Grande , Martin Michels , Stefan Weigand
发明人： Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Hein-Peter Kroll , Franz Von Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Cancho-Grande , Martin Michels , Stefan Weigand
CPC分类号： C07K5/0812 , A61K38/00
摘要： The invention relates to antibacterial amide macrocycles and process for their preparation, their use for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.
摘要翻译： 本发明涉及抗菌酰胺大环化合物及其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是细菌感染的药物的用途。
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公开(公告)号：US20080051424A1
公开(公告)日：2008-02-28
申请号：US11788649
申请日：2007-04-20
申请人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
IPC分类号： A61K31/506 , A61P31/04 , C07D239/24
CPC分类号： C07K7/06
摘要： The invention relates to nonadepsipeptides and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及非吸收肽及其制备方法以及其用于生产用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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