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公开(公告)号：US20090149528A1
公开(公告)日：2009-06-11
申请号：US12217248
申请日：2008-07-02
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Joseph Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Joseph Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
IPC分类号： A61K31/4025 , C07D207/333 , A61P31/04
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在人或动物尤其是细菌感染疾病的治疗和/或预防中的用途。
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公开(公告)号：US07402683B2
公开(公告)日：2008-07-22
申请号：US10512724
申请日：2003-04-14
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
IPC分类号： C07D207/00 , C07D215/38 , C07D213/00 , C07D403/02 , C07D231/00 , A01N43/36 , A01N43/56 , A01N43/40 , A01N43/42
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在人或动物，特别是细菌感染疾病的治疗和/或预防中的用途。
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公开(公告)号：US07348357B2
公开(公告)日：2008-03-25
申请号：US10524080
申请日：2003-07-28
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/4015 , C07D207/12
CPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在治疗和/或预防人或动物特别是细菌感染疾病中的用途。
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公开(公告)号：US20060173040A1
公开(公告)日：2006-08-03
申请号：US10524080
申请日：2003-07-28
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/422 , C07D409/02 , C07D405/02 , C07D403/02
CPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在治疗和/或预防人或动物特别是细菌感染疾病中的用途。
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公开(公告)号：US20060178369A1
公开(公告)日：2006-08-10
申请号：US10512724
申请日：2003-04-14
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/4178 , A61K31/4025
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
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6.发明授权公开(公告)号：US07544709B2
公开(公告)日：2009-06-09
申请号：US10496058
申请日：2002-11-07
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada
IPC分类号： A61K31/4015 , C07D207/40
CPC分类号： C07D207/40
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, particularly bacterial infections diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法，含有它们的药物组合物，以及它们在人或动物疾病，特别是细菌感染疾病的治疗和/或前体中的应用。 这些化合物是天然物质和杀虫剂和莫拉滨B的衍生物。
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7.发明申请公开(公告)号：US20050080129A1
公开(公告)日：2005-04-14
申请号：US10496058
申请日：2002-11-07
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Shiffer , Mitsuyuki Shimada
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Shiffer , Mitsuyuki Shimada
IPC分类号： C07D401/12 , A61K31/4015 , A61K31/4025 , A61K31/4709 , A61K31/5377 , A61P1/02 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/00 , A61P27/02 , A61P31/00 , A61P31/04 , C07D207/40 , C07D405/12 , C07D43/02
CPC分类号： C07D207/40
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法，含有它们的药物组合物及其在人或动物疾病的治疗和/或前体疾病中的用途。 这些化合物是天然物质和杀虫剂和莫拉滨B的衍生物。
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公开(公告)号：US08034817B2
公开(公告)日：2011-10-11
申请号：US10775888
申请日：2004-02-10
IPC分类号： A61K31/497 , A61K9/14 , A61K9/00 , A61K9/12
CPC分类号： A61K9/0075 , A61K31/496
摘要： The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.
摘要翻译： 本发明涉及用于局部控制呼吸器官疾病，特别是肺部疾病的吸入性喹诺酮羧酸衍生物组合物。
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公开(公告)号：US20120010215A1
公开(公告)日：2012-01-12
申请号：US13192893
申请日：2011-07-28
IPC分类号： A61K31/496 , A61P11/08 , A61P11/00 , A61P31/04
CPC分类号： A61K9/0075 , A61K31/496
摘要： The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.
摘要翻译： 本发明涉及用于局部控制呼吸器官疾病，特别是肺部疾病的吸入性喹诺酮羧酸衍生物组合物。
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公开(公告)号：US20090191123A1
公开(公告)日：2009-07-30
申请号：US12302290
申请日：2007-05-25
申请人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
发明人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
CPC分类号： A61K51/088 , A61K49/0002
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.
摘要翻译： 本发明提供了适用于纤维化的非侵入性可视化的新型成像剂。 本发明还提供了用于制备显影剂的前体，以及包含显影剂和用于制备药物组合物的试剂盒的药物组合物。 在另一方面，提供了用于体内成像和用于诊断包括纤维化的病症的药物的制备的成像剂的用途。
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