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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2023/04/18/US11629149B2/abs.jpg.150x150.jpg)
公开(公告)号：US11629149B2
公开(公告)日：2023-04-18
申请号：US16975784
申请日：2019-02-26
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号：US10660888B2
公开(公告)日：2020-05-26
申请号：US16210968
申请日：2018-12-05
Applicant: Novartis AG
Inventor： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC: A61K31/497 , C07D213/73 , C07D401/06 , C07D401/12 , C07D403/06 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04 , A61K31/44 , A61K31/4433 , A61K31/5355
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-B]pyridazine-3,5-dione Derivatives and Related Compounds as Inhibitors of the Orthomyxovirus Replication for Treating Influenza](/abs-image/US/2025/01/30/US20250034156A1/abs.jpg.150x150.jpg)
公开(公告)号：US20250034156A1
公开(公告)日：2025-01-30
申请号：US18764058
申请日：2024-07-03
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号：US10188649B2
公开(公告)日：2019-01-29
申请号：US15672568
申请日：2017-08-09
Applicant: Novartis AG
Inventor： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC: C07D241/20 , A61K31/4965 , A61K31/497 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04 , C07D213/73 , C07D401/06 , C07D401/12 , C07D403/06 , A61K31/44 , A61K31/4433 , A61K31/5355
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号：US20200079772A1
公开(公告)日：2020-03-12
申请号：US16569107
申请日：2019-09-12
Applicant: Novartis AG
Inventor： Christopher Becker , Xiaolin Li , Peichao Lu , Naomi Samadara Rajapaksa , David Charles Tully , Xiaojing Michael Wang , Qian Zhao
IPC: C07D471/04 , A61P31/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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Patent Agency Ranking
公开(公告)号：US10160726B2
公开(公告)日：2018-12-25
申请号：US15500870
申请日：2015-08-03
Applicant: NOVARTIS AG
Inventor： Javier de Vicente Fidalgo , Haiying He , Cheng Hu , Zhigan Jiang , Xiaolin Li , Peichao Lu , Wosenu Mergo , Daniel Mutnick , Folkert Reck , Alexey Rivkin , Colin Keith Skepper , Xiaojing Michael Wang , Jianhua Xia , Yongjin Xu
IPC: C07D215/38 , C07D215/22 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D419/14 , C07D471/04 , C07D471/10 , C07D487/10 , C07D498/10
Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.
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公开(公告)号：US20230052629A1
公开(公告)日：2023-02-16
申请号：US17352734
申请日：2021-06-21
Applicant: Novartis AG
Inventor： Christopher Becker , Xiaolin Li , Peichao Lu , Naomi Samadara Rajapaksa , David Charles Tully , Xiaojing Michael Wang , Qian Zhao
IPC: C07D471/04 , A61P31/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2024/08/27/US12071441B2/abs.jpg.150x150.jpg)
公开(公告)号：US12071441B2
公开(公告)日：2024-08-27
申请号：US18114336
申请日：2023-02-27
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
CPC classification number: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-B]pyridazine-3,5-dione Derivatives and Related Compounds as Inhibitors of the Orthomyxovirus Replication for Treating Influenza](/abs-image/US/2023/10/12/US20230322793A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230322793A1
公开(公告)日：2023-10-12
申请号：US18114336
申请日：2023-02-27
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
CPC classification number: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
公开(公告)号：US11072610B2
公开(公告)日：2021-07-27
申请号：US16569107
申请日：2019-09-12
Applicant: Novartis AG
Inventor： Christopher Becker , Xiaolin Li , Peichao Lu , Naomi Samadara Rajapaksa , David Charles Tully , Xiaojing Michael Wang , Qian Zhao
IPC: C07D471/04 , A61P31/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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