公开(公告)号：US20150276602A1

公开(公告)日：2015-10-01

申请号：US14738010

申请日：2015-06-12

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  G01N2021/6471 ,  G01N2201/061 ,  G02B21/16 ,  G02B23/2423 ,  G02B23/26 ,  G06T5/50 ,  G06T2207/10064 ,  G06T2207/10068 ,  G06T2207/20221

Abstract: A fluorescence observation apparatus, including: a light source configured to irradiate a subject with reference light and excitation light; and one or more processors including hardware, wherein the one or more processers are configured to implement: a fluorescence-image generating portion configured to generate a fluorescence image; a reference-image generating portion configured to generate a color reference image; an extraction portion configured to extract a fluorescence region from the fluorescence image; a motion-effect generating portion configured to generate a frame image bringing about an effect that is visually time-varying with a variation quantity depending on a gradation value of the fluorescence region, in a region corresponding to the fluorescence region; and a synthesis portion configured to add the frame image to any of a plurality of color-component images constituting the reference image to synthesize a synthetic image.

Abstract translation: 一种荧光观察装置，包括：被配置为用参考光和激发光照射对象的光源; 以及包括硬件的一个或多个处理器，其中所述一个或多个处理器被配置为实现：被配置为生成荧光图像的荧光图像生成部分; 参考图像生成部，被配置为生成颜色参考图像; 提取部，其从所述荧光图像提取荧光区域; 运动效果生成部，被配置为在对应于所述荧光区域的区域中生成引起视觉上随着所述荧光区域的灰度值的变化量而视觉上随时间变化的效果的帧图像; 以及合成部，被配置为将帧图像添加到构成参考图像的多个颜色分量图像中的任何一个，以合成合成图像。

公开(公告)号：US20130113908A1

公开(公告)日：2013-05-09

申请号：US13727164

申请日：2012-12-26

Applicant: OLYMPUS CORPORATION

Inventor： Toshiaki WATANABE ,  Yasushige ISHIHARA

IPC: H04N7/18

CPC classification number: A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  G02B23/2461 ,  G02B23/2484

Abstract: Provided is an image processing device including an illuminating portion that irradiates a subject with illumination light and excitation light; a fluorescence image-acquisition portion that acquires a fluorescence image by capturing fluorescence generated at the subject; a return-light image-acquisition portion that acquires a return-light image by capturing return light returning from the subject; a color-image generating portion that generates a plurality of color images by adding different types of color information that constitute a color space to the acquired fluorescence image and return-light image; and an image combining portion that combines the plurality of color images that have been generated, wherein at least one of the fluorescence image and the return-light image is subjected to, by the color-image generating portion), correction processing in which exponents for distance characteristics, which are approximated to exponential functions, for the fluorescence image and the return-light image are matched with each other.

Abstract translation: 提供一种图像处理装置，包括：照明部，其对照明光和激发光进行照射; 荧光图像获取部，其通过捕获在所述对象产生的荧光获取荧光图像; 返回光图像获取部分，通过捕获从被摄体返回的返回光来获取返回光图像; 彩色图像生成部，其通过向所获取的荧光图像和返回光图像添加构成颜色空间的不同类型的颜色信息来生成多个彩色图像; 以及组合所生成的多个彩色图像的图像组合部分，其中通过彩色图像生成部分对荧光图像和返回光图像中的至少一个进行处理），校正处理，其中指数 对于荧光图像和返回光图像，近似于指数函数的距离特性彼此匹配。

公开(公告)号：US20190099062A1

公开(公告)日：2019-04-04

申请号：US16207265

申请日：2018-12-03

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA ,  Kazutoshi KUMAGAI ,  Naoya SUGIMOTO

IPC: A61B1/005 ,  A61B17/04 ,  A61B1/00

Abstract: A medical device includes: a sheath that is provided with a flexible section configured to have flexibility so as to be deformed between a first shape extending along the longitudinal axis and a second shape bent in a direction intersecting the longitudinal axis; a deformation assisting member attached to the sheath so as to be movable along a surface of the sheath; a position adjustment part connected to a proximal end section of the sheath, the position adjustment part being configured to adjust a relative position of the deformation assisting member with respect to the sheath; and a curved section provided at one of the flexible section and one longitudinal section of the deformation assisting member and having a bent shape. The deformation assisting member disposed at the flexible section imparts to the flexible section a driving force for causing deformation between the first shape and the second shape.

公开(公告)号：US20160007856A1

公开(公告)日：2016-01-14

申请号：US14865499

申请日：2015-09-25

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: A61B5/00 ,  A61B1/04 ,  A61B1/06 ,  A61B1/00

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/0638 ,  G02B23/2469 ,  G02B23/2484 ,  G06T5/50 ,  G06T2207/10024 ,  G06T2207/10064 ,  G06T2207/20221 ,  G06T2207/30004

Abstract: A fluorescence observation apparatus including a light source configured to irradiate an object with white light and excitation light; and a processor comprising hardware, wherein the processor is configured to implement: a fluorescence-image generating unit and a white-light-image generating unit configured to generate a fluorescence image G2 and a color white-light image, respectively; a condition setting unit configured to set weights individually for multiple color component images constituting the white-light image; and a combining unit configured to combine at least one color component image to which the fluorescence image has been added and the other color component images while applying the weights, and the condition setting unit configured to set the weights based on the color component images such that the weight for the color component image to which the fluorescence image is added is greater than the weights for the other color component images.

Abstract translation: 一种荧光观察装置，包括被配置为用物体照射白光和激发光的光源; 以及包括硬件的处理器，其中所述处理器被配置为实现：分别生成荧光图像G2和彩色白光图像的荧光图像生成单元和白光图像生成单元; 条件设置单元，被配置为针对构成白光图像的多个颜色分量图像分别设置权重; 以及组合单元，被配置为在施加所述权重的同时，组合至少一个已经添加了所述荧光图像的颜色分量图像和所述其它颜色分量图像，并且所述条件设置单元被配置为基于所述颜色分量图像来设置所述权重，使得 添加荧光图像的颜色分量图像的重量大于其他颜色分量图像的权重。

公开(公告)号：US20150257635A1

公开(公告)日：2015-09-17

申请号：US14725667

申请日：2015-05-29

Applicant: OLYMPUS CORPORATION

Inventor： Kei KUBO ,  Yasushige ISHIHARA ,  Hiromi SHIDA

IPC: A61B1/06 ,  A61B1/04 ,  A61B1/00

CPC classification number: A61B1/0638 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  G02B23/2484 ,  G02B23/26 ,  H04N2005/2255

Abstract: An observation apparatus including a light source that irradiates a subject with illumination light and special light that acts on a specific region of the subject; and a processor comprising hardware, wherein the processor is configured to implement: a return-light-image generating portion that generates a return-light image based on captured return light coming from the subject due to irradiation with the illumination light; a special-light-image generating portion that generates a special-light image based on captured signal light coming from the subject due to irradiation with the special light; an extraction portion that extracts the specific region from the special-light image; and an enhancement processing portion that performs enhancement processing, which is based on return-light image information, on the return-light image, in a region corresponding to the extracted specific region.

Abstract translation: 一种观察装置，包括：用照明光照射被检体的光源和作用于被检体的特定区域的特殊光; 以及包括硬件的处理器，其中所述处理器被配置为实现：返回光图像生成部分，其基于由于照射所述照明光而从所述被摄体发出的所捕获的返回光产生返回光图像; 特殊光图像生成部，其基于由所述特殊光照射而从所述被检体取得的信号光产生特殊光图像; 提取部，其从所述特殊光图像提取所述特定区域; 以及增强处理部，其对与所提取的特定区域对应的区域，在返回光图像上进行基于返回光图像信息的增强处理。

公开(公告)号：US20140161369A1

公开(公告)日：2014-06-12

申请号：US14173202

申请日：2014-02-05

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: G01N21/64 ,  G06T5/00

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  G02B23/2461 ,  G06T5/009

Abstract: A fluoroscopy apparatus includes a preprocessing section that multiplies at least one of a fluorescence image and a reference-light image by a coefficient by which distance characteristics of fluorescence intensity and distance characteristics of return-light intensity acquired from a standard sample in advance are made directly proportional to each other to generate a correction fluorescence image and a correction reference-light image; a divided-image generating section that divides the correction fluorescence image by the correction reference-light image to generate a divided image; a threshold-setting section that sets a threshold based on a mean grayscale level of pixels in the divided image; an image-adjusting section that enhances contrast between a region with grayscale levels above the set threshold set by the threshold-setting section and a region with grayscale levels below the threshold in the divided image; and a monitor that displays the divided image with the enhanced contrast.

Abstract translation: 荧光透视设备包括：预处理部分，其将荧光图像和参考光图像中的至少一个乘以直接从标准样品获取的荧光强度和返回光强度的距离特性的距离特性和距离特性的系数 彼此成比例地产生校正荧光图像和校正参考光图像; 分割图像生成部，其将校正用荧光图像除以校正基准光图像，生成分割图像; 阈值设定部，其基于分割图像中的像素的平均灰度级设定阈值; 图像调整部，其增强在阈值设定部设定的设定阈值以上的灰度等级的区域与分割图像的灰度级低于阈值的区域之间的对比度; 以及显示器，其显示具有增强的对比度的分割图像。

公开(公告)号：US20140037179A1

公开(公告)日：2014-02-06

申请号：US13952954

申请日：2013-07-29

Applicant: OLYMPUS MEDICAL SYSTEMS CORP. ,  OLYMPUS CORPORATION

Inventor： Hiromi SHIDA ,  Yasushige ISHIHARA ,  Satoshi TAKEKOSHI ,  Kei KUBO

IPC: A61B5/00

CPC classification number: A61B5/0033 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00055 ,  A61B1/043 ,  G06T5/50 ,  G06T7/0014 ,  G06T2207/10121 ,  G06T2207/30088

Abstract: Provided is a fluoroscopy apparatus including a light source that irradiates an observation target with reference light and excitation light; a fluorescence-image generating unit that captures fluorescence emitted from the observation target X irradiated with the excitation light to generate a fluorescence image; a reference-image generating unit that captures return light returning from the observation target irradiated with the reference light to generate a reference image; an image-combining unit that superimposes the fluorescence image on the reference image to generate a combined image; a determining unit that determines whether there is a position with a luminance at or below a predetermined threshold in the reference image; and a notifying unit that, if the determining unit determines that there is a position with a luminance at or below the predetermined threshold, provides notification thereof.

Abstract translation: 本发明提供一种荧光透视设备，包括：用参考光和激发光照射观察目标的光源; 荧光图像生成单元，其捕获从所述观察对象物X发射的荧光，所述荧光被激发光照射，以产生荧光图像; 参考图像生成单元，其捕获从所述观察对象返回的照射了所述基准光的返回光，生成参照图像; 图像合成单元，其将所述荧光图像叠加在所述参考图像上以生成组合图像; 确定单元，确定参考图像中是否存在亮度在预定阈值以下的位置; 以及通知单元，如果所述确定单元确定存在具有或低于所述预定阈值的亮度的位置，则提供通知。

公开(公告)号：US20150016705A1

公开(公告)日：2015-01-15

申请号：US14499813

申请日：2014-09-29

Applicant: OLYMPUS CORPORATION ,  OLYMPUS MEDICAL SYSTEMS CORP.

Inventor： Kei KUBO ,  Yasushige ISHIHARA ,  Hiromi SHIDA ,  Satoshi TAKEKOSHI

IPC: G01N21/64 ,  G06K9/46 ,  G06T7/00

CPC classification number: G01N21/6456 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00055 ,  A61B1/043 ,  A61B1/045 ,  F04C2270/041 ,  G01N2201/124 ,  G06K9/4604 ,  G06T7/0012 ,  G06T2207/30004

Abstract: The invention provides a fluoroscopy apparatus including an image-capturing device that acquires a fluorescence image of a subject; a sensitivity adjusting portion that sets a sensitivity of the image-capturing device to fluorescence on the basis of a gradation value of the fluorescence image; a notifying portion that extracts a lesion part from the fluorescence image acquired by the image-capturing device with the sensitivity set by the sensitivity adjusting portion and presents it to an operator; and a display switching portion that displays the fluorescence image on a display unit when the sensitivity in the image-capturing device is equal to or less than a predetermined threshold and that presents information showing the existence of the lesion part on the notifying portion when the sensitivity is greater than the predetermined threshold.

Abstract translation: 本发明提供一种荧光透视装置，其包括获取被检体的荧光图像的图像捕获装置; 灵敏度调整部，其基于荧光图像的灰度值，将图像拍摄装置的感光度设定为荧光; 通知部，其以由灵敏度调节部设定的灵敏度从由摄像装置获取的荧光图像中提取病变部，并将其呈现给操作者; 以及显示切换部，当所述图像拍摄装置的灵敏度为规定阈值以下时，在所述显示部显示所述荧光图像，并且当所述灵敏度为灵敏度时，在所述通知部显示所述病变部的存在信息 大于预定阈值。

公开(公告)号：US20140184790A1

公开(公告)日：2014-07-03

申请号：US14197614

申请日：2014-03-05

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: G01N21/64 ,  G06T5/00

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/00039 ,  A61B1/043 ,  G06T5/00

Abstract: The purpose is to reduce correction errors and acquire quantitative information of an object. Provided is a fluorescence observation device including: a light source; a fluorescence-image generation part that acquires a fluorescence image of an object F irradiated with excitation light; a white-light-image generation part that acquires a white-light image of the object F irradiated with illumination light; an image correction part that generates a corrected fluorescence image from these images; a threshold setting part that sets a threshold based on the average of gradation values of the entire image, a first coefficient therefor, the standard deviation of the gradation values of the image, and a second coefficient therefor; an extraction part that determines and extracts a region in the image that has a gradation value exceeding the threshold, as a region of interest; a monitor that displays the region of interest and the image in association with each other; and an input section through which an observer inputs a result as to whether the determination made by the extraction part is right or wrong, in which the threshold setting part sets at least one of the first coefficient and the second coefficient so as to reflect the input result input through the input section.

Abstract translation: 目的是减少校正误差并获取对象的定量信息。 本发明提供一种荧光观察装置，包括：光源; 获取被激发光照射的被摄体F的荧光图像的荧光图像生成部; 白光图像生成部，其获取用照明光照射的被摄体F的白光图像; 图像校正部，其从这些图像生成校正的荧光图像; 阈值设定部，其基于整个图像的灰度值的平均值，第一系数，图像的灰度值的标准偏差和第二系数来设定阈值; 提取部，其确定并提取具有超过阈值的灰度值的图像中的区域作为关注区域; 监视器，其显示相关联的区域和图像; 以及输入部分，观察者通过该输入部分输入关于提取部分做出的确定是否是对的结果，其中阈值设置部分设置第一系数和第二系数中的至少一个，以便反映输入 结果输入通过输入部分。

公开(公告)号：US20140049626A1

公开(公告)日：2014-02-20

申请号：US14058907

申请日：2013-10-21

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige ISHIHARA

IPC: G01N21/64

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00096 ,  A61B1/043

Abstract: Provided is a fluoroscopy apparatus including illuminating portions that radiate excitation light and illumination light onto an imaging subject; a fluorescence imaging portion that acquires a fluorescence image from fluorescence emitted at the imaging subject due to the irradiation with the excitation light; a return-light imaging portion that acquires a return-light image from return light returning from the imaging subject due to the irradiation with the illumination light; a display portion that displays the acquired fluorescence image and/or the return-light image; an identifying portion that identifies a region-of-interest in the fluorescence image; an image switching portion that switches the display on the display portion so that only the return-light image is displayed thereon when the region-of-interest R is not identified, and so that the return-light image and the fluorescence image are juxtaposed and displayed on the display portion when the region-of-interest has been identified.

Abstract translation: 本发明提供一种荧光透视设备，其包括将激发光和照明光辐射到成像对象上的照明部分; 荧光成像部，其由于激发光的照射而从成像对象发射的荧光获取荧光图像; 返回光成像部，其从由所述照明光的照射而从所述摄像对象返回的返回光获取返回光图像; 显示所获取的荧光图像和/或返回光图像的显示部分; 标识部分，其识别所述荧光图像中的感兴趣区域; 图像切换部，其在显示部切换显示部，使得当没有识别出感兴趣区域R时仅显示返回光图像，并且使得返回光图像和荧光图像并置，并且 当识别出感兴趣区域时，显示在显示部分上。