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公开(公告)号：US20190167083A1
公开(公告)日：2019-06-06
申请号：US16272312
申请日：2019-02-11
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki WATANABE
Abstract: An endoscope system includes: a light source apparatus configured to emit excitation light for exciting a fluorescent medical agent and illuminating light; an image sensor configured to pick up an image of each of fluorescence emitted in response to application of the excitation light to an object present inside a body cavity of a subject to which the fluorescent medical agent is administered and reflected light emitted in response to application of the illuminating light to the object; and a mixed image generating circuit configured to generate an observation image in which a first image that is an image obtained by performing image pickup of the reflected light by the image sensor, and a second image that is an image indicating a site of emission of the fluorescence in the object are mixed in a set of pixel arrays that do not overlap each other and each have periodicity.
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公开(公告)号：US20200322512A1
公开(公告)日：2020-10-08
申请号：US16906641
申请日：2020-06-19
Applicant: OLYMPUS CORPORATION
Inventor： Susumu AONO , Toshiaki WATANABE , Satoshi TAKEKOSHI , Masakazu MIZOGUCHI , Junichi TASHIRO
Abstract: An endoscope system is provided with: a processor; a light source; and an image pickup device. The processor performs control for causing reflected light images corresponding to a predetermined period before start of the fluorescence occurrence period during the fluorescence non-occurrence period, among the reflected light images, to be recorded to the first storage medium; and, furthermore, performs control for causing the reflected light images to be recorded to the first storage medium during an after-end-of-fluorescence-occurrence period corresponding to a predetermined period with an end of the fluorescence occurrence period as a start point, and performs control for causing the reflected light images not to be recorded to the first storage medium during the fluorescence non-occurrence period after an end of the after-end-of-fluorescence-occurrence period.
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公开(公告)号：US20190388702A1
公开(公告)日：2019-12-26
申请号：US16012827
申请日：2018-06-20
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki WATANABE , Masahiro YOSHINO , Tetsuhide TAKEYAMA , Motohiro MITAMURA
Abstract: A tumor treatment method for treating a tumor in a subject, the method includes: a step I of administering a therapeutically effective amount of one or a plurality of antibody-IR 700 molecules to the subject, in which the antibody specifically binds to a cell surface protein of the tumor; a step II of inserting an optical probe into the subject; a step III of applying light having a wavelength in a range from 660 nm to 740 nm from the optical probe, to supply energy of at least 1 J/cm2 to at least a part of the tumor; a step IV of waiting for a time until an immune response is elicited in the tumor; a step V of inserting an energy device into the subject; and a step VI of resecting tissues of the subject including the tumor using the energy device.
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公开(公告)号：US20170086659A1
公开(公告)日：2017-03-30
申请号：US15371831
申请日：2016-12-07
Applicant: OLYMPUS CORPORATION
Inventor： Hiroki UCHIYAMA , Toshiaki WATANABE , Yuichi TAKEUCHI
CPC classification number: A61B1/043 , A61B1/00 , A61B1/04 , A61B5/0059 , G02B23/24 , G06K9/2054 , G06K9/4661 , G06K9/6202 , G06T7/0014 , G06T2207/10064 , G06T2207/10068 , H04N7/18
Abstract: A diagnosis assisting apparatus includes a region extraction section configured to extract, from among fluorescence images obtained by picking up images of fluorescence emitted from a desired object, a reference region to be handled as a reference for a fluorescence generation state and a region of interest to be handled as a comparison target of the fluorescence generation state, respectively, a calculation processing section configured to acquire a reference value corresponding to a luminance value of each pixel included in the reference region and calculate a calculation value obtained by dividing the luminance value of the region of interest by a representative value, a storage section configured to store the calculation value calculated by the calculation processing section, and an image processing section configured to cause a display apparatus to display information indicating a variation over time of the calculation value stored in the storage section.
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公开(公告)号：US20130338438A1
公开(公告)日：2013-12-19
申请号：US13908116
申请日：2013-06-03
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki WATANABE
CPC classification number: A61B1/043 , A61B1/00009 , A61B1/0002 , A61B1/00045 , A61B1/0638 , A61B1/0646 , A61B1/0684
Abstract: A fluorescence endoscope apparatus includes: a light source unit emitting light in a combination of light in plural types of wavelength bands in two types of wavelength ranges of RGB and two types of exciting light, with plural types of emitting patterns and in a time division; an image pickup unit receiving reflected light and two types of fluorescence; and an image-processing unit outputting a white light image and two types of fluorescence images.
Abstract translation: 一种荧光内窥镜装置，包括：以两种类型的波长范围的RGB和两种激发光以多种类型的波长范围的光组合发光的光源单元，具有多种类型的发射图案和时分; 接收反射光和两种类型的荧光的图像拾取单元; 以及输出白光图像和两种类型的荧光图像的图像处理单元。
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Patent Agency Ranking
公开(公告)号：US20170303775A1
公开(公告)日：2017-10-26
申请号：US15646498
申请日：2017-07-11
Applicant: OLYMPUS CORPORATION
Inventor： Hiroki UCHIYAMA , Toshiaki WATANABE , Misa TSURUTA , Yuichi TAKEUCHI
CPC classification number: A61B1/043 , A61B1/00006 , A61B1/00045 , A61B1/045 , A61B1/053 , A61B1/0638 , A61B1/0646 , A61B1/07
Abstract: An endoscope apparatus enables observation using reflected light of white light and observation using fluorescence, and includes: an insertion portion configured to be insertable into a subject; an objective optical system; a transmitting optical system; a camera unit; an optical splitter configured to split light exiting through the transmitting optical system; an optical filter disposed in the transmitting optical system or the camera unit, the optical filter being configured to transmit the reflected light of the white light and the fluorescence and block the reflected light of the excitation light; a first image pickup device for picking up an image of the reflected light of the white light exiting through the optical filter and the optical splitter; and a second image pickup device for picking up an image of the fluorescence exiting through the optical filter and the optical splitter.
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公开(公告)号：US20140092390A1
公开(公告)日：2014-04-03
申请号：US14097360
申请日：2013-12-05
Applicant: Olympus Corporation
Inventor： Toshiaki WATANABE
IPC: G01J3/28
CPC classification number: G01J3/2823 , G01J3/26 , G01N21/6456 , G01N2021/6423
Abstract: An apparatus for obtaining spectral image includes a variable spectral element capable of changing its spectral characteristics, a transmission wavelength setting unit for setting a wavelength of light to be transmitted by the variable spectral element, a variable spectral element control unit changing a first control of the variable spectral element and a second control of the variable spectral element for controlling spectral characteristics of the variable spectral element to each other, an image capturing unit capturing an image that is formed by light transmitted by the variable spectral element, and an image correction unit acquiring a difference image between a first image captured in the first control and a second image captured in the second control.
Abstract translation: 用于获得光谱图像的装置包括能够改变其光谱特性的可变光谱元件，用于设置由可变光谱元件发送的光的波长的透射波长设置单元，改变第一控制的可变光谱元素控制单元 可变光谱元件和可变光谱元件的第二控制，用于控制可变光谱元素彼此的光谱特性，捕获由可变光谱元件发射的光形成的图像的图像捕获单元，以及图像校正单元获取 在第一控制中捕获的第一图像与在第二控制中捕获的第二图像之间的差分图像。
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公开(公告)号：US20140213871A1
公开(公告)日：2014-07-31
申请号：US14242111
申请日：2014-04-01
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki WATANABE
CPC classification number: A61B5/02042 , A61B1/043
Abstract: Provided is a fluorescence observation apparatus including a light source; a section generating a fluorescence image of an object; a section generating a reference image of the object; a section generating a corrected image in which emphasized are pixels of the reference image corresponding to pixels each having luminance value equal to or more than a first threshold value in the fluorescence image; a display unit displaying the reference image or the corrected image; a bleeding state determining section determining whether or not a bleeding region of the subject detected based on the reference image is more than a predetermined range; and a section switching between displaying the reference image on the display unit if the determining section determines that the region is not more than the range, and displaying the corrected on the image display if the determining section determines that the region is more than the range.
Abstract translation: 提供了一种荧光观察装置，其包括光源; 产生物体的荧光图像的部分; 生成对象的参考图像的部分; 产生校正图像的部分，其中强调是与荧光图像中具有等于或大于第一阈值的像素对应的参考图像的像素; 显示单元，显示参考图像或校正图像; 判定基于所述参照图像检测出的被检体的出血区域是否大于预定范围的出血状态判定部; 以及如果所述确定部确定所述区域不大于所述范围，则在所述显示单元上显示所述参考图像之间切换，以及如果所述确定部确定所述区域超过所述范围，则在所述图像显示上显示所述校正。
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公开(公告)号：US20130113908A1
公开(公告)日：2013-05-09
申请号：US13727164
申请日：2012-12-26
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki WATANABE , Yasushige ISHIHARA
IPC: H04N7/18
CPC classification number: A61B1/00009 , A61B1/043 , A61B1/0638 , A61B1/0646 , G02B23/2461 , G02B23/2484
Abstract: Provided is an image processing device including an illuminating portion that irradiates a subject with illumination light and excitation light; a fluorescence image-acquisition portion that acquires a fluorescence image by capturing fluorescence generated at the subject; a return-light image-acquisition portion that acquires a return-light image by capturing return light returning from the subject; a color-image generating portion that generates a plurality of color images by adding different types of color information that constitute a color space to the acquired fluorescence image and return-light image; and an image combining portion that combines the plurality of color images that have been generated, wherein at least one of the fluorescence image and the return-light image is subjected to, by the color-image generating portion), correction processing in which exponents for distance characteristics, which are approximated to exponential functions, for the fluorescence image and the return-light image are matched with each other.
Abstract translation: 提供一种图像处理装置，包括：照明部，其对照明光和激发光进行照射; 荧光图像获取部，其通过捕获在所述对象产生的荧光获取荧光图像; 返回光图像获取部分，通过捕获从被摄体返回的返回光来获取返回光图像; 彩色图像生成部，其通过向所获取的荧光图像和返回光图像添加构成颜色空间的不同类型的颜色信息来生成多个彩色图像; 以及组合所生成的多个彩色图像的图像组合部分，其中通过彩色图像生成部分对荧光图像和返回光图像中的至少一个进行处理），校正处理，其中指数 对于荧光图像和返回光图像，近似于指数函数的距离特性彼此匹配。
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公开(公告)号：US20200315439A1
公开(公告)日：2020-10-08
申请号：US16907499
申请日：2020-06-22
Applicant: OLYMPUS CORPORATION
Inventor： Masakazu MIZOGUCHI , Toshiaki WATANABE , Satoshi TAKEKOSHI , Susumu AONO
Abstract: An endoscope system includes a processor configured to generate a clock at predetermined timing, a light source apparatus configured to irradiate white light and excitation light in a time division manner in synchronization with the clock, and an endoscope configured to perform image pickup based on irradiation timing of the light source apparatus. The processor generates a first white light image at a first clock, generates a first fluorescent image at a second clock, generates a second white light image at a third clock, and generates a third white light image at a fourth clock and superimposes the second white light image and the first fluorescent image at the fourth clock and superimposes the third white light image and the first fluorescent image at a fifth clock.
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