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公开(公告)号：US20130200273A1
公开(公告)日：2013-08-08
申请号：US13834395
申请日：2013-03-15
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki Watanabe , Yasushige Ishihara
IPC: G01N21/64
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , G01N21/6454 , G01N21/6456 , G01N21/6486 , G06T5/009 , H04N5/2351
Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.
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公开(公告)号：US10219701B2
公开(公告)日：2019-03-05
申请号：US14865499
申请日：2015-09-25
Applicant: OLYMPUS CORPORATION
Inventor： Yasushige Ishihara
Abstract: A fluorescence observation apparatus including a light source configured to irradiate an object with white light and excitation light; and a processor comprising hardware, wherein the processor is configured to implement: a fluorescence-image generating unit and a white-light-image generating unit configured to generate a fluorescence image G2 and a color white-light image, respectively; a condition setting unit configured to set weights individually for multiple color component images constituting the white-light image; and a combining unit configured to combine at least one color component image to which the fluorescence image has been added and the other color component images while applying the weights, and the condition setting unit configured to set the weights based on the color component images such that the weight for the color component image to which the fluorescence image is added is greater than the weights for the other color component images.
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公开(公告)号：US09513221B2
公开(公告)日：2016-12-06
申请号：US13950376
申请日：2013-07-25
Applicant: OLYMPUS CORPORATION
Inventor： Yasushige Ishihara
CPC classification number: G01N21/6456 , A61B1/00006 , A61B1/00009 , A61B1/043 , A61B5/0071 , G01N21/6486 , H04N5/2353 , H04N5/347 , H04N2005/2255
Abstract: Observation is performed at a more appropriate sensitivity without causing deterioration of the image quality. Provided is a fluorescence observation apparatus including an excitation light source that emits excitation light to be radiated onto an imaging subject; a fluorescence-image acquisition portion that is provided with an imaging device that acquires fluorescence images by capturing fluorescence generated at the imaging subject due to the irradiation with the excitation light emitted from the excitation light source; and a sensitivity adjusting portion that adjusts an number of pixels for binning summing and/or an exposure time for the imaging device on the basis of luminance information of the fluorescence image acquired by the imaging device of the fluorescence-image acquisition portion so that an SN ratio of the fluorescence image becomes equal to or higher than a predetermined threshold.
Abstract translation: 以更适当的灵敏度进行观察，而不会导致图像质量的劣化。 本发明提供一种荧光观察装置，其包括：发射激发光的激发光源，照射到摄像对象上; 荧光图像获取部分，其设置有成像装置，其通过从由激发光源发射的激发光的照射捕获在成像对象产生的荧光来获取荧光图像; 以及灵敏度调整部，其基于由所述荧光图像获取部的摄像装置获取的荧光图像的亮度信息，调整所述摄像装置的叠加加和/或曝光时间的像素数，使得SN 荧光图像的比例变得等于或高于预定阈值。
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4.发明授权公开(公告)号：US09460496B2
公开(公告)日：2016-10-04
申请号：US14100422
申请日：2013-12-09
Applicant: OLYMPUS CORPORATION
Inventor： Yasushige Ishihara
CPC classification number: G06T5/006 , A61B1/0005 , A61B1/00059 , A61B1/00186 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0669
Abstract: There is provided a fluorescence observation apparatus, including: a lighting section including a light source emitting illumination light and excitation light; a fluorescence imaging section picking up fluorescence generated on a subject and acquiring a fluorescence image; a returned light imaging section picking up returned light returned from the subject and acquiring a returned light image; a preprocessing section multiplying at least either the fluorescence image or the returned light image by a coefficient in which a distance property of fluorescence intensity and a distance property of returned light intensity, which are acquired in advance with respect to a standard sample, come to be in a relation directly proportional to each other and generating a fluorescence image for correction and a returned light image for correction; and a fluorescence image correction section dividing the fluorescence image for correction by the returned light image for correction.
Abstract translation: 提供了一种荧光观察装置，包括：发光部，其具备发出照明光和激发光的光源; 荧光成像部，其拾取对象产生的荧光并获取荧光图像; 返回的光成像部拾取从被检体返回的返回光并获取返回的光图像; 至少将荧光图像或返回的光图像乘以其中相对于标准样品预先获取的荧光强度的距离属性和返回光强度的距离属性的系数成为的预处理部分 以相互直接成比例的关系产生用于校正的荧光图像和用于校正的返回光图像; 以及荧光图像校正部，将用于校正的荧光图像除以所述返回光图像进行校正。
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公开(公告)号：US08818062B2
公开(公告)日：2014-08-26
申请号：US13645083
申请日：2012-10-04
Applicant: Olympus Corporation
Inventor： Yasushige Ishihara
CPC classification number: A61B6/504 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/043 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0669 , G06T5/009 , G06T5/50
Abstract: A fluoroscopy device includes a light source that irradiates an observation site with excitation light and white light; a fluorescence-image generating section that acquires a fluorescence image by capturing fluorescence generated in the observation site irradiated with the excitation light; a reference-image generating section that acquires a reference image by capturing return light returning from the observation site irradiated with the white light; an observation-condition determining section that determines the observation conditions of the observation site on the basis of the reference image acquired by the reference-image generating section; a preprocessing section that corrects gradation values of the reference image on the basis of the observation conditions of the observation site; and a fluorescence-image correcting section that generates a corrected fluorescence image by dividing the fluorescence image acquired by the fluorescence-image generating section by the reference image whose gradation values have been corrected by the preprocessing section.
Abstract translation: 荧光透视装置包括：用激发光和白光照射观察部位的光源; 荧光图像生成部，其通过捕获在被激发光照射的观察部位中产生的荧光获取荧光图像; 参考图像生成部，其通过捕获从所述观察部位返回的从所述白光照射的返回光获取参照图像; 观察条件确定部，其基于由参考图像生成部获取的参考图像来确定观察部位的观察条件; 基于所述观察部位的观察条件来校正所述参照图像的灰度值的预处理部; 以及荧光图像校正部，其通过将由所述荧光图像生成部获取的荧光图像除以由所述预处理部修正了灰度值的参照图像来生成校正后的荧光图像。
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Patent Agency Ranking
公开(公告)号：US08718397B2
公开(公告)日：2014-05-06
申请号：US13834898
申请日：2013-03-15
Applicant: Olympus Corporation
Inventor： Toshiaki Watanabe , Yasushige Ishihara
IPC: G06K9/00
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , G01N21/6454 , G01N21/6456 , G01N21/6486 , G06T5/009 , H04N5/2351
Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.
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公开(公告)号：US09901253B2
公开(公告)日：2018-02-27
申请号：US15163739
申请日：2016-05-25
Applicant: OLYMPUS CORPORATION
Inventor： Yasushige Ishihara
CPC classification number: A61B5/0071 , A61B1/04 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/7425 , A61B2562/0233
Abstract: A fluorescence observation apparatus comprising a light source having a single light-emitting portion for emitting white light and excitation light simultaneously and radiates the white light and the excitation light; a light guide that guides the radiated white and excitation lights and simultaneously irradiates the white and excitation lights light onto a specimen; a white-light-image acquisition unit that receives return light of the white light coming from the specimen and acquires a white-light image; a fluorescence-image acquisition unit that receives fluorescence excited in the specimen by the excitation light and acquires a fluorescence image; an illumination-light filter that is disposed between the light-emitting portion and a radiation exit end of the light source, and satisfies the following conditional expression, Pf(λw)
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公开(公告)号：US09839359B2
公开(公告)日：2017-12-12
申请号：US15046860
申请日：2016-02-18
Applicant: OLYMPUS CORPORATION
Inventor： Kei Kubo , Yasushige Ishihara
IPC: A61B5/00 , H04N7/18 , A61B1/00 , A61B1/04 , A61B1/045 , G06T5/50 , G06T5/00 , G06T19/00 , G06T19/20 , A61B1/06
CPC classification number: A61B5/0071 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , G06T5/008 , G06T5/50 , G06T19/006 , G06T19/20 , G06T2207/10064 , G06T2207/10068 , G06T2207/20212
Abstract: A fluorescence observation apparatus including a light source that radiates illumination light and excitation light; a return-light-image generating portion and a fluorescence-image generating portion that generate a return-light image and a fluorescence image, respectively; a fluorescence detecting portion that detects a fluorescence region in the fluorescence image; a return-light-image adjusting portion that adjusts gradation values of the return-light image; a superimposed-image generating portion that generates a superimposed image by using the return-light image, in which the gradation values have been adjusted, and the fluorescence image; and a coefficient setting portion that sets, in the case in which the fluorescence region is detected, a degree-of-reduction of the gradation values, so that the gradation values of the return-light image are decreased as compared with the case in which the fluorescence region is not detected.
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公开(公告)号：US09588046B2
公开(公告)日：2017-03-07
申请号：US14198671
申请日：2014-03-06
Applicant: OLYMPUS CORPORATION , OLYMPUS MEDICAL SYSTEMS CORP.
Inventor： Yasushige Ishihara , Hiromi Shida , Kei Kubo , Satoshi Takekoshi
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/0005 , A61B1/043 , G01N21/6456 , G06T5/50 , G06T2207/20216
Abstract: Provided is a fluorescence observation apparatus including: a fluorescence image acquisition section and a reference image acquisition section that acquire a fluorescence image and a reference image of a subject, respectively; a division image generation section that generates a division image by dividing an image based on the fluorescence image by an image based on the reference image; a display section that displays a corrected fluorescence image based on the division image; a correction processing section that applies correction processing to at least one of the reference image and the fluorescence image and/or to the division image prior to the generation of the division image or prior to the display of the corrected fluorescence image; an observation condition determination section that determines observation conditions of the subject; and a correction condition setting section that sets parameters regarding the correction processing according to the observation conditions.
Abstract translation: 本发明提供一种荧光观察装置，包括：荧光图像获取部和参考图像获取部，分别获取被检体的荧光图像和参照图像; 分割图像生成部，其通过基于所述参照图像将基于所述荧光图像的图像分割为图像来生成分割图像; 显示部，其基于所述分割图像显示校正的荧光图像; 校正处理部，其在所述分割图像的生成之前或所述校正后的荧光图像的显示之前，对所述参考图像和所述荧光图像和/或所述分割图像中的至少一个进行校正处理; 观察条件确定部，其确定被检体的观察条件; 以及校正条件设定部，其根据观察条件设定关于校正处理的参数。
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公开(公告)号：US09392942B2
公开(公告)日：2016-07-19
申请号：US13952954
申请日：2013-07-29
Applicant: OLYMPUS CORPORATION
Inventor： Hiromi Shida , Yasushige Ishihara , Satoshi Takekoshi , Kei Kubo
CPC classification number: A61B5/0033 , A61B1/00009 , A61B1/0005 , A61B1/00055 , A61B1/043 , G06T5/50 , G06T7/0014 , G06T2207/10121 , G06T2207/30088
Abstract: Provided is a fluoroscopy apparatus including a light source that irradiates an observation target with reference light and excitation light; a fluorescence-image generating unit that captures fluorescence emitted from the observation target X irradiated with the excitation light to generate a fluorescence image; a reference-image generating unit that captures return light returning from the observation target irradiated with the reference light to generate a reference image; an image-combining unit that superimposes the fluorescence image on the reference image to generate a combined image; a determining unit that determines whether there is a position with a luminance at or below a predetermined threshold in the reference image; and a notifying unit that, if the determining unit determines that there is a position with a luminance at or below the predetermined threshold, provides notification thereof.
Abstract translation: 本发明提供一种荧光透视设备，包括：用参考光和激发光照射观察目标的光源; 荧光图像生成单元，其捕获从所述观察对象物X发射的荧光，所述荧光被激发光照射，以产生荧光图像; 参考图像生成单元，其捕获从所述观察对象返回的照射了所述基准光的返回光，生成参照图像; 图像合成单元，其将所述荧光图像叠加在所述参考图像上以生成组合图像; 确定单元，确定参考图像中是否存在亮度在预定阈值以下的位置; 以及通知单元，如果所述确定单元确定存在具有或低于所述预定阈值的亮度的位置，则提供通知。
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