公开(公告)号：US20240307869A1

公开(公告)日：2024-09-19

申请号：US18576158

申请日：2022-06-21

Applicant: OPTOLANE TECHNOLOGIES INC.

Inventor： Seung Sun CHO ,  An Shik CHOI ,  Byoung Joo KWAK ,  Sergiy OLEKSANDROV

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L2200/0642 ,  B01L2300/044 ,  B01L2300/0663 ,  B01L2300/0819 ,  B01L2300/161 ,  B01L2400/0406

Abstract: Disclosed is a PCR module in which a sample can be injected using the capillary effect. The PCR module comprises: a microfluidic chamber which includes an inlet part for inputting a sample and is manufactured by injection molding; a well array which is disposed on the lower surface of the microfluidic chamber and includes a plurality of micro-wells of which the upper and lower portions are perforated; and a capillary member providing a path so that the sample input through the inlet part reaches the micro-wells through the capillary effect. When moving a PCR solution to a reaction space using the capillary effect and filling the reaction space with the solution, it is possible to prevent air pockets from forming in the corners or edge regions of the well array which is the reaction space. Accordingly, it is possible to prevent errors caused by air pockets from occurring in PCR test results. In addition, since the well array is located on a CMOS photosensor array, PCR reactions can be measured in real time.

公开(公告)号：US20250091053A1

公开(公告)日：2025-03-20

申请号：US18580994

申请日：2022-06-24

Applicant: OPTOLANE TECHNOLOGIES INC.

Inventor： Seung Sun CHO ,  Won Yong CHOI ,  Sang Hoon LEE

IPC: B01L9/00

Abstract: Disclosed is a molecular diagnosis cartridge which is formed so that a molecular diagnosis chip can be easily inserted therein. The molecular diagnosis cartridge accommodating the molecular diagnosis chip comprises: a cartridge bottom member arranged on the lower portion; a hinge sub-ring arranged along the outer circumference of the cartridge bottom member; a cartridge outline member which is accommodated in a space defined by the hinge sub-ring fastened with the cartridge bottom member; a chip sliding member which has a shape surrounding the molecular diagnosis chip, is arranged on the cartridge outline member, and accommodates the molecular diagnosis chip that is inserted in an inclined direction; and a torsion spring-like member which is fastened with a kind of a seesaw axle protruding from the inner wall of the cartridge outline member, supports the chip sliding member to be inclined with respect to the cartridge bottom member in an open mode operation, and supports the chip sliding member to be parallel to the cartridge bottom member in a close mode operation. According to the present invention, the molecular diagnosis chip is inclinedly inserted in the chip sliding member, and easiness in insertion of the molecular diagnosis chip can be achieved. Also, as the cartridge cover is pressed, the chip sliding member accommodating the molecular diagnosis chip makes a seesaw movement on the basis of the seesaw axle and is moved to the cartridge bottom member, and thus, the molecular diagnosis chip arranged in the chip sliding member can be seated in the molecular diagnosis cartridge.

公开(公告)号：US20240286126A1

公开(公告)日：2024-08-29

申请号：US18573475

申请日：2022-06-10

Applicant: OPTOLANE TECHNOLOGIES INC.

Inventor： Seung Sun CHO ,  An Shik CHOI ,  Byoung Joo KWAK ,  Sergiy OLEKSANDROV ,  Jae Hun KIM

IPC: B01L3/00

CPC classification number: B01L3/502 ,  B01L2200/0684 ,  B01L2200/14 ,  B01L2300/042 ,  B01L2300/0829 ,  B01L2300/161 ,  B01L2400/088

Abstract: Disclosed is an in vitro diagnostic chip having multiple levels of hydrophilicity, which differentially controls the flow rates of a liquid sample and thus enables the liquid sample to be evenly distributed all the way to corner or edge regions of a reaction space. The in vitro diagnostic chip having multiple levels of hydrophilicity comprises: a well array comprising a plurality of wells; and a multi-hydrophilic coating layer coated on the well array and controlling the flow rates of a sample so as to be mutually different. The hydrophilic coating layer is formed on the well array so as to have high hydrophilicity in accordance with the center region of the well array, and to have low hydrophilicity in accordance with the peripheral region of the well array, and thus the formation of an air pocket in the reaction space may be blocked. Accordingly, the occurrence of an error caused by the air pocket in a PCR test result may be prevented.