公开(公告)号：US20160271611A1

公开(公告)日：2016-09-22

申请号：US15064816

申请日：2016-03-09

Applicant: OPTOLANE Technologies Inc.

Inventor： DoYoung LEE ,  In Gyun JEON ,  An Shik CHOI ,  Kyung Hak CHOI

IPC: B01L7/00 ,  C12Q1/68

CPC classification number: B01L7/52 ,  B01L3/50851 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/185 ,  C12Q1/686 ,  G01N21/64

Abstract: A polymerase chain reaction (PCR) module is detachably combined with a reader system. The reader system includes a central processing unit (CPU) receiving a photo sensing signal to calculate gene amplification amount in real time and generating a temperature control signal based on a temperature signal and a temperature control information. The PCR module includes a photo sensor assembly, a partition wall, and an interface module. The photo sensor assembly includes a plurality of photo sensors and a temperature sensor. The photo sensors are arranged in an array shape to sense emission light generated from a specimen to generate the photo sensing signal. The partition wall is protruded from the photo sensor assembly to define a reaction space in which the specimen is received. The interface module is electrically connected to the photo sensor assembly to transmit the photo sensing signal and the temperature signal to the reader system.

Abstract translation: 聚合酶链反应（PCR）模块可与读取器系统可拆卸地组合。 读取器系统包括中央处理单元（CPU），其接收感光信号以实时计算基因放大量，并且基于温度信号和温度控制信息产生温度控制信号。 PCR模块包括光传感器组件，分隔壁和接口模块。 光传感器组件包括多个光传感器和温度传感器。 光传感器被布置成阵列形状以检测从样本产生的发射光以产生光感测信号。 分隔壁从光传感器组件突出以限定其中接收样品的反应空间。 接口模块电连接到光传感器组件，以将感光信号和温度信号传输到读取器系统。

公开(公告)号：US20190217303A1

公开(公告)日：2019-07-18

申请号：US16361594

申请日：2019-03-22

Applicant: OPTOLANE Technologies Inc.

Inventor： DoYoung LEE ,  In Gyun JEON ,  An Shik CHOI ,  Kyung Hak CHOI

IPC: B01L7/00 ,  B01L3/00 ,  G01N21/64 ,  C12Q1/686

Abstract: A polymerase chain reaction (PCR) module is detachably combined with a reader system. The reader system includes a central processing unit (CPU) receiving a photo sensing signal to calculate gene amplification amount in real time and generating a temperature control signal based on a temperature signal and a temperature control information. The PCR module includes a photo sensor assembly, a partition wall, and an interface module. The photo sensor assembly includes a plurality of photo sensors and a temperature sensor. The photo sensors are arranged in an array shape to sense emission light generated from a specimen to generate the photo sensing signal. The partition wall is protruded from the photo sensor assembly to define a reaction space in which the specimen is received. The interface module is electrically connected to the photo sensor assembly to transmit the photo sensing signal and the temperature signal to the reader system.

公开(公告)号：US20190329254A1

公开(公告)日：2019-10-31

申请号：US16390380

申请日：2019-04-22

Applicant: OPTOLANE Technologies Inc.

Inventor： Sergiy OLEKSANDROV ,  Do Young LEE ,  Min Sik SONG ,  Kyung Hak CHOI

IPC: B01L3/00 ,  C12Q1/6806 ,  C12Q1/686

Abstract: A cartridge for digital real-time Polymerase chain reaction (PCR) includes a microfluidic chamber, a well array, a CMOS photo sensor array and a PCB. The microfluidic chamber includes an inlet formed for injection of a liquid sample, the microfluidic chamber being capable of injection molding. The well array includes a plurality of microwells through which upper and lower portions are perforated and being attached to a lower surface of the microfluidic chamber. The CMOS photo sensor array is disposed below the well array to capture a response image of a sample filled in microwells of the well array. The PCB has a vent formed for vacuum processing of micro flow path formed in the microfluidic chamber, a space formed between the well array and the microfluidic chamber, and a microwell formed in the well array as the liquid sample is injected through the inlet.