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    Pharmaceuticals That Promote Functional Regeneration of Damaged Tissues
    2.
    发明公开
    Pharmaceuticals That Promote Functional Regeneration of Damaged Tissues 审中-公开

    公开(公告)号：US20240050460A1

    公开(公告)日：2024-02-15

    申请号：US18152249

    申请日：2023-01-10

    Applicant: StemRIM Inc. ,  Osaka University

    Inventor： Katsuto TAMAI ,  Takehiko YAMAZAKI ,  Yasufumi KANEDA

    IPC: A61K31/711 ,  G01N33/68 ,  C07K14/52 ,  G01N33/50

    CPC classification number: A61K31/711 ,  G01N33/6863 ,  C07K14/52 ,  G01N33/5073 ,  A61K38/00

    Abstract: The present inventors revealed the following for the first time in the world:



    1) a large amount of bone marrow-derived cells are mobilized to grafted skin;
    2) the mobilized bone marrow-derived cells are differentiated into any of dermal fibroblasts, adipocytes, muscle cells, vascular endothelial cells, and epidermal keratinocytes in the grafted skin, and the mobilized bone marrow-derived cells include bone marrow-derived mesenchymal stem cells;
    3) the factors which mobilize bone marrow-derived mesenchymal stem cells from peripheral blood to the grafted skin are HMGB1, HMGB2, and HMGB3 released from the necrosed tissue of recipient skin;
    4) purified HMGB1, HMGB2, and HMGB3 promote the migration of mesenchymal stem cells isolated and cultured from bone marrow;
    5) activators containing HMGB1 which allows the migration of bone marrow mesenchymal stem cells can be conveniently purified from several organ extracts including skin, brain, and heart;
    6) activators which allow the migration of bone marrow mesenchymal stem cells can be conveniently extracted from cultured cells; and
    7) a heparin-column purified fraction of skin extract mobilizes a large amount of bone marrow-derived cells in case of brain injury.

    IMMUNOSTIMULATING COMPOSITION
    4.
    发明申请
    IMMUNOSTIMULATING COMPOSITION 有权

    公开(公告)号：US20220202846A1

    公开(公告)日：2022-06-30

    申请号：US17310002

    申请日：2020-01-09

    Applicant: OSAKA UNIVERSITY ,  DAICEL CORPORATION

    Inventor： Tomoyuki NISHIKAWA ,  Yasufumi KANEDA ,  Kunihiko YAMASHITA ,  Ayano SUZUKI ,  Kazuhiro TERAI

    IPC: A61K31/713 ,  C12N15/117 ,  A61P35/00

    Abstract: An object of the present disclosure is at least to provide a technique for stimulating immunity in mammals, and the object is fulfilled by double-stranded RNA composed of: RNA composed of a base sequence represented by a sequence A below; and RNA composed of a base sequence represented by a sequence B below, each base of an (N)13-25 portion in the base sequence represented by the sequence A and the base sequence represented by the sequence B being or not being complementary bases, and all of the bases of (N)5-10 portions in the base sequence represented by the sequence A and the base sequence represented by the sequence B being complementary bases, and a Tm value of the (N)5-10 portion being 20° C. or higher: Sequence A: 5′-UUGUCAUAUGGACAAGUCCAAGACU(N)13-25(N)5-10-3′ (SEQ ID No: 1), and Sequence B: 5′-(N)5-10(N)13-25AGUCUUGGACUUGUCCAUAUGACAA-3′ (SEQ ID No: 2).

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