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公开(公告)号:US06548651B1
公开(公告)日:2003-04-15
申请号:US09689155
申请日:2000-10-12
申请人: Peter E. Nielsen , Liam Good , Henrik Frydenlund Hansen , Frederik Beck , Leila Malik , Carsten Schou , Margit Wissenbach , Birgit Kjaeldgaard Giwercman
发明人: Peter E. Nielsen , Liam Good , Henrik Frydenlund Hansen , Frederik Beck , Leila Malik , Carsten Schou , Margit Wissenbach , Birgit Kjaeldgaard Giwercman
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A61K38/00 , A61K47/62 , A61L2/0082 , C12N2310/152 , C12N2310/3181 , C12N2310/323 , C12N2310/3233 , C12N2310/33 , C12N2310/3513
摘要: The present invention relates to novel drugs which may be used in combating infectious micro-organisms, particularly bacteria. More specifically, the invention relates to peptide nucleic acid (PNA) sequences that are modified by conjugating cationic peptides to the PNA moiety in order to obtain novel PNA molecules that exhibit enhanced anti-infective properties.
摘要翻译: 本发明涉及可用于对抗感染性微生物,特别是细菌的新型药物。 更具体地,本发明涉及通过将阳离子肽与PNA部分缀合而修饰的肽核酸(PNA)序列,以获得表现出增强的抗感染性质的新型PNA分子。
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公开(公告)号:US20120122880A1
公开(公告)日:2012-05-17
申请号:US13265149
申请日:2010-04-20
IPC分类号: A61K31/496 , A61K31/4535 , A61P31/00 , C07D409/06
CPC分类号: C07D409/06 , A61K31/4436 , A61K31/496 , A61K45/06 , C07D335/20
摘要: The claimed subject matter is directed to certain thioxanthene derivatives and phenothiazine derivatives suitable for use as anti-infective agents, in particular, for the treatment of infectious diseases. The claimed subject matter furthermore relates to compositions including said anti-infective agents.
摘要翻译: 所要求保护的主题涉及适合用作抗感染剂的某些噻吨衍生物和吩噻嗪衍生物,特别是用于治疗感染性疾病。 所要求保护的主题还涉及包含所述抗感染剂的组合物。
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公开(公告)号:US20080318970A1
公开(公告)日:2008-12-25
申请号:US11579021
申请日:2005-04-29
IPC分类号: A61K31/382 , A61P31/04 , A61K31/496 , A61P31/12
CPC分类号: A61K45/06 , A61K31/352 , A61K2300/00
摘要: The present invention is directed to the use of chemosensitising compounds, in particular thioxanthene derivatives and phenothiazine derivatives, for treatment of infectious diseases in combination with an anti-infective agent. The invention furthermore relates to compositions comprising said chemosensitising compounds and anti-infective agents.
摘要翻译: 本发明涉及化学敏化化合物,特别是噻吨衍生物和吩噻嗪衍生物用于与抗感染剂组合治疗感染性疾病的用途。 本发明还涉及包含所述化学敏化化合物和抗感染剂的组合物。
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