公开(公告)号：US08153950B2

公开(公告)日：2012-04-10

申请号：US12337771

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Joerg Martini ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Joerg Martini ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01J1/42 ,  F21V9/16 ,  G01N21/25

CPC分类号： G01J3/2803 ,  G01J3/02 ,  G01J3/027 ,  G01N15/12 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1075 ,  G01N2021/1734

摘要： An encoder/sensor can obtain sensing results from objects in an encoding/sensing region; a trigger detector can respond to objects in a trigger detection region, providing respective trigger signals; and a relative motion component can cause relative motion of objects into the trigger detection region, from it into the encoding/sensing region, and within the encoding/sensing region. In response to an object's trigger signal, control circuitry can cause the encoder/sensor and/or the relative motion component to operate so that the encoder/sensor obtains sensing results indicating a time-varying waveform and processing circuitry can obtain data from the sensing results indicating a time-varying waveform. The time-varying waveform can include information resulting from the relative motion within the encoding/sensing region. The encoder/sensor and trigger detector can be implemented, for example, with discrete components or as sets of cells in a photosensing array on an integrated circuit.

摘要翻译： 编码器/传感器可以从编码/感测区域中的对象获得感测结果; 触发检测器可以响应触发检测区域中的对象，提供相应的触发信号; 并且相对运动分量可以引起物体进入触发检测区域的相对运动，从而进入编码/感测区域，并且在编码/感测区域内。 响应于物体的触发信号，控制电路可以使编码器/传感器和/或相对运动分量运行，使得编码器/传感器获得指示时变波形的感测结果，并且处理电路可以从感测结果获得数据 表示时变波形。 时变波形可以包括由编码/感测区域内的相对运动产生的信息。 编码器/传感器和触发检测器可以例如利用集成电路中的光敏阵列中的分立组件或单元组来实现。

公开(公告)号：US20110222062A1

公开(公告)日：2011-09-15

申请号：US13113021

申请日：2011-05-20

申请人： Joerg Martini ,  Peter Kiesel ,  Malte Huck ,  Marshall Bern ,  Noble M. Johnson ,  Michael Bassler ,  Markus Beck

发明人： Joerg Martini ,  Peter Kiesel ,  Malte Huck ,  Marshall Bern ,  Noble M. Johnson ,  Michael Bassler ,  Markus Beck

IPC分类号： G01N21/25 ,  G01N21/64

CPC分类号： G01N21/25 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/255 ,  G01N21/645 ,  G01N2021/0346 ,  G02B21/16 ,  G02B27/46

摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.

摘要翻译： 滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。 例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。 或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。 可以使用许多过滤装置，例如 过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。 可以比较感测结果中的时变波形，以获得光谱差异。 在实用的商业实施例中，过滤器装置可以制造为一次性的，并且用于实际上在任何地方，以低成本使用的点护理装置，并且也可以在在线监测系统中实现。

公开(公告)号：US20100155572A1

公开(公告)日：2010-06-24

申请号：US12337771

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Joerg Martini ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Joerg Martini ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01J1/44 ,  G01J1/20

CPC分类号： G01J3/2803 ,  G01J3/02 ,  G01J3/027 ,  G01N15/12 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1075 ,  G01N2021/1734

摘要： An encoder/sensor can obtain sensing results from objects in an encoding/sensing region; a trigger detector can respond to objects in a trigger detection region, providing respective trigger signals; and a relative motion component can cause relative motion of objects into the trigger detection region, from it into the encoding/sensing region, and within the encoding/sensing region. In response to an object's trigger signal, control circuitry can cause the encoder/sensor and/or the relative motion component to operate so that the encoder/sensor obtains sensing results indicating a time-varying waveform and processing circuitry can obtain data from the sensing results indicating a time-varying waveform. The time-varying waveform can include information resulting from the relative motion within the encoding/sensing region. The encoder/sensor and trigger detector can be implemented, for example, with discrete components or as sets of cells in a photosensing array on an integrated circuit.

摘要翻译： 编码器/传感器可以从编码/感测区域中的对象获得感测结果; 触发检测器可以响应触发检测区域中的对象，提供相应的触发信号; 并且相对运动分量可以引起物体进入触发检测区域的相对运动，从而进入编码/感测区域，并且在编码/感测区域内。 响应于物体的触发信号，控制电路可以使编码器/传感器和/或相对运动分量运行，使得编码器/传感器获得指示时变波形的感测结果，并且处理电路可以从感测结果获得数据 表示时变波形。 时变波形可以包括由编码/感测区域内的相对运动产生的信息。 编码器/传感器和触发检测器可以例如利用集成电路中的光敏阵列中的分立组件或单元组来实现。

公开(公告)号：US08153949B2

公开(公告)日：2012-04-10

申请号：US12337737

申请日：2008-12-18

申请人： Peter Kiesel ,  Joerg Martini ,  Michael Bassler ,  Markus Beck ,  Noble M. Johnson

发明人： Peter Kiesel ,  Joerg Martini ,  Michael Bassler ,  Markus Beck ,  Noble M. Johnson

IPC分类号： G01J1/42 ,  F21V9/16 ,  G01N21/25

CPC分类号： G01N15/1429 ,  G01N15/1056 ,  G01N15/12 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1075

摘要： In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways.

摘要翻译： 响应于相对于编码器/传感器在编码/感测区域内具有相对运动的物体，例如，发出光的光照或执行基于阻抗的感测，感测结果可以指示感测到的具有关于物体的信息的时变波形，关于它们 相对运动，关于激发特性，关于环境特性等。 编码器/传感器可以包括例如感测元件的非周期性布置; 具有组合感测图案的感测元件的纵向序列，其近似于更简单的感测图案的叠加或缩放叠加; 和/或IC实现的感测元件，其包括IC上的光敏阵列和读出/组合电路，其根据单元组感测图案从组中的单元读出光照量，并组合读出的光照量以获得感测结果。 物体可以像流式细胞仪一样流动地进行扫描运动，如文档扫描或其他方式。

公开(公告)号：US08629981B2

公开(公告)日：2014-01-14

申请号：US13113021

申请日：2011-05-20

申请人： Joerg Martini ,  Peter Kiesel ,  Malte Huck ,  Marshall W. Bern ,  Noble M. Johnson ,  Michael Bassler ,  Markus Beck

发明人： Joerg Martini ,  Peter Kiesel ,  Malte Huck ,  Marshall W. Bern ,  Noble M. Johnson ,  Michael Bassler ,  Markus Beck

IPC分类号： G01N21/25 ,  G01P3/36

CPC分类号： G01N21/25 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/255 ,  G01N21/645 ,  G01N2021/0346 ,  G02B21/16 ,  G02B27/46

摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences.

摘要翻译： 滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。 例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。 或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。 可以使用许多过滤装置，例如 过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。 可以比较感测结果中的时变波形，以获得光谱差异。

公开(公告)号：US20100155577A1

公开(公告)日：2010-06-24

申请号：US12337737

申请日：2008-12-18

申请人： Peter Kiesel ,  Joerg Martini ,  Michael Bassler ,  Markus Beck ,  Noble M. Johnson

发明人： Peter Kiesel ,  Joerg Martini ,  Michael Bassler ,  Markus Beck ,  Noble M. Johnson

IPC分类号： G01J1/42 ,  G06F15/00 ,  G01N21/00

CPC分类号： G01N15/1429 ,  G01N15/1056 ,  G01N15/12 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1075

摘要： In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways.

摘要翻译： 响应于在编码/感测区域内相对于编码器/传感器具有相对运动的物体，例如，发出光的光照或执行基于阻抗的感测，感测结果可以指示感测到的具有关于物体的信息的时变波形，关于它们 相对运动，关于激发特性，关于环境特性等。 编码器/传感器可以包括例如感测元件的非周期性布置; 具有组合感测图案的感测元件的纵向序列，其近似于更简单的感测图案的叠加或缩放叠加; 和/或IC实现的感测元件，其包括IC上的光敏阵列和读出/组合电路，其根据单元组感测图案从组中的单元读出光照量，并组合读出的光照量以获得感测结果。 物体可以像流式细胞仪一样流动地进行扫描运动，如文档扫描或其他方式。

公开(公告)号：US08320983B2

公开(公告)日：2012-11-27

申请号：US11957610

申请日：2007-12-17

申请人： Joerg Martini ,  Jeffrey Roe ,  Peter Kiesel ,  Michael Bassler ,  Alan Bell ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Joerg Martini ,  Jeffrey Roe ,  Peter Kiesel ,  Michael Bassler ,  Alan Bell ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： A61B5/1455

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  G01N21/03 ,  G01N21/39 ,  G01N21/8507

摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.

摘要翻译： 诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。 该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度， 作为全宽半最大值（FWHM）。 分析物，例如 葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。 因此，来自容器的输出光包括关于分析物的信息。

公开(公告)号：US20100157291A1

公开(公告)日：2010-06-24

申请号：US12337796

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01N21/01

CPC分类号： G01N15/1429 ,  G01N15/1459 ,  G01N21/532 ,  G01N21/645 ,  G01N21/65 ,  G01N2015/1075

摘要： Sensors can be used to obtain encoded sensing results from objects that have nonuniform relative motion. A photosensor or impedance-based sensor, for example, can obtain sensing results from objects that have relative motion within a sensing region relative to the sensor, with the relative motion being, for example, periodically varying, randomly varying, chirp-varying, or modulated relative motion that completes at least one modulation cycle within the sensing region. Relative motion can be caused by varying objects' speed and/or direction or by controlling flow of fluid carrying objects, movement of a channel, movement of a support structure, movement of a sensor, and/or pattern movement. A fluidic implementation can include shaped channel wall parts and/or a displacement component causing time-varying lateral displacement. A support structure implementation can include a scanner device and a rotary device that respectively control scanning and rotating movement of a movable support structure or of a sensor.

摘要翻译： 传感器可用于从具有不均匀相对运动的物体获得编码的感测结果。 例如，光传感器或基于阻抗的传感器可以从相对于传感器的感测区域内具有相对运动的物体获得感测结果，相对运动例如是周期性变化的，随机变化的线性调频脉冲变化或 调制的相对运动，其在感测区域内完成至少一个调制周期。 可以通过改变物体的速度和/或方向或通过控制流体携带物体的流动，通道的移动，支撑结构的运动，传感器的运动和/或图案运动来引起相对运动。 流体实现可以包括形成通道壁部分和/或引起时变横向位移的位移部件。 支撑结构实现可以包括分别控制可移动支撑结构或传感器的扫描和旋转运动的扫描器装置和旋转装置。

公开(公告)号：US20090195852A1

公开(公告)日：2009-08-06

申请号：US12025394

申请日：2008-02-04

申请人： Michael Bassler ,  Peter Kiesel ,  Markus Beck ,  Alex Hegyi ,  Tobias Buergel ,  Noble M. Johnson

发明人： Michael Bassler ,  Peter Kiesel ,  Markus Beck ,  Alex Hegyi ,  Tobias Buergel ,  Noble M. Johnson

IPC分类号： G02F1/01

CPC分类号： G01N21/645 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/53 ,  G01N21/6486 ,  G01N2021/0346 ,  G01N2021/6421 ,  G01N2021/6471

摘要： A transmissive and/or reflective optical filter can receive input light, which can emanate from objects traveling along paths past the filter, e.g. from biological cells, viruses, colored spots or other markings on documents, and so forth. In response, the filter can provide output light in accordance with a combined transmission function that is approximately equal to a superposition or scaled superposition of a set of simpler transmission functions. The set can include two or more non-uniform transmission functions, a subset of which can be different from each other and positioned relative to each other so that the output light has time variation in accordance with each of the functions in the subset. The subset could include, for example, a random function and a periodic function, a chirp function and a periodic function, or any other suitable combination of two or more simpler functions.

摘要翻译： 透射和/或反射光学滤光器可以接收输入光，其可以从沿着过滤器的路径行进的物体发射，例如， 来自生物细胞，病毒，彩色斑点或文件上的其他标记等等。 作为响应，滤波器可以根据组合传输函数提供输出光，其大致等于一组更简单的传输函数的叠加或缩放叠加。 该集合可以包括两个或多个非均匀传输函数，其子集可以彼此不同并且相对于彼此定位，使得输出光具有根据子集中的每个功能的时间变化。 子集可以包括例如随机函数和周期函数，啁啾函数和周期函数，或两个或更多个更简单函数的任何其它合适的组合。

公开(公告)号：US08263955B2

公开(公告)日：2012-09-11

申请号：US12337796

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01N21/55 ,  G01N21/25 ,  G01N21/00

CPC分类号： G01N15/1429 ,  G01N15/1459 ,  G01N21/532 ,  G01N21/645 ,  G01N21/65 ,  G01N2015/1075

摘要： Sensors can be used to obtain encoded sensing results from objects that have nonuniform relative motion. A photosensor or impedance-based sensor, for example, can obtain sensing results from objects that have relative motion within a sensing region relative to the sensor, with the relative motion being, for example, periodically varying, randomly varying, chirp-varying, or modulated relative motion that completes at least one modulation cycle within the sensing region. Relative motion can be caused by varying objects' speed and/or direction or by controlling flow of fluid carrying objects, movement of a channel, movement of a support structure, movement of a sensor, and/or pattern movement. A fluidic implementation can include shaped channel wall parts and/or a displacement component causing time-varying lateral displacement. A support structure implementation can include a scanner device and a rotary device that respectively control scanning and rotating movement of a movable support structure or of a sensor.

摘要翻译： 传感器可用于从具有不均匀相对运动的物体获得编码的感测结果。 例如，光传感器或基于阻抗的传感器可以从相对于传感器的感测区域内具有相对运动的物体获得感测结果，相对运动例如是周期性变化的，随机变化的线性调频脉冲变化或 调制的相对运动，其在感测区域内完成至少一个调制周期。 可以通过改变物体的速度和/或方向或通过控制流体携带物体的流动，通道的移动，支撑结构的运动，传感器的运动和/或图案运动来引起相对运动。 流体实现可以包括形成通道壁部分和/或引起时变横向位移的位移部件。 支撑结构实现可以包括分别控制可移动支撑结构或传感器的扫描和旋转运动的扫描器装置和旋转装置。