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公开(公告)号：US20170151341A1
公开(公告)日：2017-06-01
申请号：US15356750
申请日：2016-11-21
Applicant: Pfizer Inc.
Inventor： Dangshe MA , Frank LOGANZO, JR. , Kimberly Ann MARQUETTE , Edmund Idris GRAZIANI , Puja SAPRA , Pavel STROP
Abstract: The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
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公开(公告)号：US20130129753A1
公开(公告)日：2013-05-23
申请号：US13670612
申请日：2012-11-07
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
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Patent Agency Ranking
公开(公告)号：US20200377615A1
公开(公告)日：2020-12-03
申请号：US16891460
申请日：2020-06-03
Applicant: Pfizer Inc.
Inventor： Dangshe MA , Frank LOGANZO, Jr. , Kimberly Ann MARQUETTE , Edmund Idris GRAZIANI , Puja SAPRA , Pavel STROP
Abstract: The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
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公开(公告)号：US20200069764A1
公开(公告)日：2020-03-05
申请号：US16688173
申请日：2019-11-19
Applicant: Pfizer Inc.
Inventor： Dangshe MA , Kimberly Ann MARQUETTE , Edmund Idris GRAZIANI , Puja SAPRA , Lawrence Nathan TUMEY , Nadira Anarkali PRASHAD , Kiran Manohar KHANDKE , Eric M. BENNETT , Lioudmila TCHISTIAKOVA
Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.
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公开(公告)号：US20170216452A1
公开(公告)日：2017-08-03
申请号：US15356953
申请日：2016-11-21
Applicant: Pfizer Inc.
Inventor： Dangshe MA , Kimberly Ann MARQUETTE , Edmund Idris GRAZIANI , Puja SAPRA , Lawrence Nathan TUMEY , Nadira Anarkali PRASHAD , Kiran Manohar KHANDKE , Eric M. BENNETT , Lioudmila TCHISTIAKOVA
CPC classification number: A61K38/05 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K16/283 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.
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公开(公告)号：US20150307551A1
公开(公告)日：2015-10-29
申请号：US14793942
申请日：2015-07-08
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
IPC: C07K7/06
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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公开(公告)号：US20140363452A1
公开(公告)日：2014-12-11
申请号：US14322262
申请日：2014-07-02
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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