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    TREATMENT AND PREVENTION OF CANCEROUS AND PRE-CANCEROUS CONDITIONS OF THE LIVER, LUNG AND ESOPHAGUS
    6.
    发明申请
    TREATMENT AND PREVENTION OF CANCEROUS AND PRE-CANCEROUS CONDITIONS OF THE LIVER, LUNG AND ESOPHAGUS 审中-公开
    治疗和预防肝癌，肺癌和ESOPHAGUS癌症和癌前病变

    公开(公告)号：US20110117108A1

    公开(公告)日：2011-05-19

    申请号：US13012433

    申请日：2011-01-24

    申请人： Philip C. Gevas ,  Dov Michaeli ,  Stephen Grimes

    发明人： Philip C. Gevas ,  Dov Michaeli ,  Stephen Grimes

    IPC分类号： A61K39/395 ,  A61K39/00 ,  A61P35/00

    CPC分类号： C07K14/72 ,  A61K2039/505

    摘要： The invention relates to the treatment and/or prevention of cancerous and/or, precancerous conditions of the liver, lung and esophagus by actively and/or passively immunizing a patient against the peptide hormone gastrin and/or a gastrin receptor, e.g., the CCK-B/gastrin receptor. The immunizations of the invention may be employed as a monotherapy, an adjunctive therapy, or as part of a combination therapy.

    摘要翻译： 本发明涉及通过主动地和/或被动地免疫患者对肽激素胃泌素和/或胃泌素受体（例如CCK）来治疗和/或预防肝，肺和食道的癌性和/或癌前病症 -B /胃泌素受体。 本发明的免疫可用作单一疗法，辅助治疗或组合疗法的一部分。

    Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
    8.
    发明授权
    Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors 失效
    CCK-B /胃泌素受体的免疫原性组合物和治疗肿瘤的方法

    公开(公告)号：US06548066B1

    公开(公告)日：2003-04-15

    申请号：US09076372

    申请日：1998-05-12

    申请人： Dov Michaeli ,  Martyn Caplin ,  Susan A. Watson ,  Stephen Grimes

    发明人： Dov Michaeli ,  Martyn Caplin ,  Susan A. Watson ,  Stephen Grimes

    IPC分类号： A61K39385

    CPC分类号： C07K14/72 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/0011 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K16/2869 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/77 ,  G01N33/57488

    摘要： The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B/gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B/gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.

    摘要翻译： 本发明涉及用于治疗胃泌素依赖性肿瘤的免疫原，免疫原性组合物和方法。 免疫原包含与间隔基缀合的CCK-B /胃泌素受体的肽和免疫原性载体。 免疫原能够在体内诱导结合肿瘤细胞中的CCK-B /胃泌素受体的抗体，从而防止生长刺激肽激素与受体结合并抑制肿瘤细胞生长。 免疫原还包括针对被动免疫的CCK-B /胃泌素受体的抗体。 本发明还涉及使用本发明的抗体在体内或组织活组织检查中检测胃泌素依赖性肿瘤的诊断方法。

    Chimeric peptide immunogens
    9.
    发明申请
    Chimeric peptide immunogens 审中-公开
    嵌合肽免疫原

    公开(公告)号：US20070184064A1

    公开(公告)日：2007-08-09

    申请号：US10886038

    申请日：2004-07-06

    申请人： Stephen Grimes ,  Dov Michaeli ,  Vernon Stevens

    发明人： Stephen Grimes ,  Dov Michaeli ,  Vernon Stevens

    IPC分类号： A61K39/12

    CPC分类号： A61K39/0006 ,  A61K39/00 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/6068 ,  C07K7/23 ,  C07K2319/00 ,  Y02A50/412

    摘要： Chimeric peptide epitopes can serve as effective immunogens against hormones and other small peptides or proteins. Thus, immunogenic peptides are selected from promiscuous Th epitopes and synthesized together with self antigenic peptide sequences fused with or without end to end spacer peptide interconnections. A peptide sequence which may be of the gonadotropin releasing hormone is linked with an immunogenic peptide sequence selected from a promiscuous Th-epitope of measles virus protein F, tetanus toxoid, or malaria protein CSP. Compositions of the chimeric immunogen are found effective in eliciting high and specific anti-GnRH antibody titers.

    摘要翻译： 嵌合肽表位可以作为针对激素和其他小肽或蛋白质的有效免疫原。 因此，免疫原性肽选自混杂的Th表位，并与与或不与端到端间隔肽互连融合的自身抗原肽序列一起合成。 可以是促性腺激素释放激素的肽序列与选自麻疹病毒蛋白F，破伤风类毒素或疟疾蛋白CSP的混杂Th-表位的免疫原性肽序列连接。 发现嵌合免疫原的组合物在引发高和特异性抗GnRH抗体滴度方面是有效的。