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1.发明申请Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists 审中-公开可用作组胺H3受体拮抗剂和/或反激动剂的哌嗪酮衍生物公开(公告)号：US20080275027A1
公开(公告)日：2008-11-06
申请号：US11995929
申请日：2006-07-17
申请人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotic Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
发明人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotic Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
IPC分类号： C07D241/08 , A61K31/497 , C07D401/12 , A61P37/00 , A61P37/08 , A61K31/55 , C07D403/12
CPC分类号： C07D487/04 , C07D241/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D409/14 , C07D413/10 , C07D417/14
摘要： The invention relates to compounds of formula (I) or salts and solvates thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis: wherein R1 and R2 are as defined in the specification.
摘要翻译： 本发明涉及式（I）化合物或其盐和溶剂合物，其制备方法，含有它们的组合物及其在治疗各种疾病如抗过敏性鼻炎中的用途：其中R 1〜 >和R 2-2如说明书中所定义。
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公开(公告)号：US20080207638A1
公开(公告)日：2008-08-28
申请号：US11995927
申请日：2006-07-17
申请人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
发明人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
IPC分类号： A61K31/4965 , C07D241/02 , A61P11/00
CPC分类号： C07D403/12
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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![Pyrazolo [3,4-D]Azepine Derivatives as Histamine H3 Antagonists](/abs-image/US/2008/07/24/US20080176832A1/abs.jpg.150x150.jpg)
公开(公告)号：US20080176832A1
公开(公告)日：2008-07-24
申请号：US11994689
申请日：2006-07-04
IPC分类号： A61K31/55 , C07D487/04 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的式I的吡唑衍生物，其具有作为其制备的H3拮抗剂的方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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公开(公告)号：US08207331B2
公开(公告)日：2012-06-26
申请号：US12707147
申请日：2010-02-17
申请人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
发明人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04
摘要： The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的新的苯并氮杂衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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![Pyrazolo [3,4-D]azepine derivatives as histamine H3 antagonists](/abs-image/US/2011/02/15/US07888347B2/abs.jpg.150x150.jpg)
5.发明授权公开(公告)号：US07888347B2
公开(公告)日：2011-02-15
申请号：US11994689
申请日：2006-07-04
IPC分类号： A61P25/28 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的式I的吡唑衍生物，其具有作为其制备的H3拮抗剂的方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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6.发明授权公开(公告)号：US07297693B2
公开(公告)日：2007-11-20
申请号：US10488579
申请日：2002-09-05
申请人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
发明人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/506 , A61K31/443 , A61K31/4439 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/14
CPC分类号： C07D451/04 , C07D405/04 , C07D405/14 , C07D409/04
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译： 化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。
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公开(公告)号：US07799773B2
公开(公告)日：2010-09-21
申请号：US12339145
申请日：2008-12-19
申请人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
发明人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
IPC分类号： A61P7/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04
摘要： The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的新的苯并氮杂衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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公开(公告)号：US20100145040A1
公开(公告)日：2010-06-10
申请号：US12707147
申请日：2010-02-17
申请人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
发明人： Mark James Bamford , David Kenneth Dean , Sanjeet Singh Sehmi , David Matthew Wilson , Jason Witherington
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04
摘要： The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的新的苯并氮杂衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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公开(公告)号：US07452906B2
公开(公告)日：2008-11-18
申请号：US10488580
申请日：2002-09-05
申请人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
发明人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/445 , C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D405/04 , C07D405/14
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译： 化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。
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公开(公告)号：US07348339B2
公开(公告)日：2008-03-25
申请号：US10508760
申请日：2003-03-21
申请人： Nicholas Bailey , Mark James Bamford , Haifeng Cui , Stephen Garland , Krista B Goodman , Mark A Hilfiker , Dennis Lee , Terence Aaron Panchal , Robert A Stavenger , David Matthew Wilson , Jason Witherington
发明人： Nicholas Bailey , Mark James Bamford , Haifeng Cui , Stephen Garland , Krista B Goodman , Mark A Hilfiker , Dennis Lee , Terence Aaron Panchal , Robert A Stavenger , David Matthew Wilson , Jason Witherington
IPC分类号： A61K31/44 , A01N43/42 , C07D265/30 , C07D295/00 , C07D498/02
CPC分类号： C07D471/04
摘要： A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
摘要翻译： 下式的化合物及其生理上可接受的盐和/或其N-氧化物，其中X 1是N或CR 3; X 2是N或CR 4; X 3是N或CR 5; X 4是N或CR 6。 条件是X 1，X 2，X 3和X 4中的至少一个但不多于两个， SUB>表示N. R 1是选自a，b，c或d的5-或6-元杂环基，其中X 5是选自 N或CR 7和X 6是选自O，S或NR 8的基团; X 7和X 8可以相同或不同，是选自N或CR 9的基团。 X 9是选自O，S或NR 8和X 10的基团是N或CR 10; X 11，X 12和X 13可以相同或不同，并且选自N或C 11 ; 其制备方法，含有它们的药物组合物及其在医药中的用途。
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