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公开(公告)号：US08221765B2
公开(公告)日：2012-07-17
申请号：US12470989
申请日：2009-05-22
申请人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
发明人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
IPC分类号： A61K38/17 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/74
摘要： The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及包含通过多肽接头连接的至少两个纤连蛋白支架结构域的多价多肽。 本发明还涉及用于诊断，研究和治疗应用的多价多肽。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US08728483B2
公开(公告)日：2014-05-20
申请号：US13533382
申请日：2012-06-26
申请人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
发明人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
IPC分类号： A61K38/39 , A61K47/48 , C07K14/705 , C07K14/78 , C07K14/435
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/74
摘要： The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及包含通过多肽接头连接的至少两个纤连蛋白支架结构域的多价多肽。 本发明还涉及用于诊断，研究和治疗应用的多价多肽。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20130012435A1
公开(公告)日：2013-01-10
申请号：US13533382
申请日：2012-06-26
申请人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
发明人： Ray Camphausen , Eric Furfine , Irvith M. Carvajal , H. Nicholas Marsh , Marco Gottardis , Joan Carboni , Ricardo Attar
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/00 , C07K2319/74
摘要： The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US20100179094A1
公开(公告)日：2010-07-15
申请号：US12625217
申请日：2009-11-24
申请人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
发明人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
摘要翻译： 本发明涉及包含EGFR结合结构域和用于诊断，研究和治疗应用的不同IGFIR结合结构域的双特异性分子。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码创新蛋白质的多核苷酸的载体。 示例性双特异性分子包括基于第十纤连蛋白III型结构域的抗体样蛋白二聚体。
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公开(公告)号：US08343501B2
公开(公告)日：2013-01-01
申请号：US12625217
申请日：2009-11-24
申请人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
发明人： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao , Marco Gottardis , Joan Carboni
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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公开(公告)号：US08969289B2
公开(公告)日：2015-03-03
申请号：US13098851
申请日：2011-05-02
申请人： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
发明人： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
CPC分类号： C12P21/005 , A61K38/00 , A61K47/62 , A61K47/643 , C07K14/435 , C07K14/50 , C07K14/575 , C07K14/78 , C07K2319/70 , C12N15/62
摘要： The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
摘要翻译： 本发明涉及基于结合血清白蛋白的第十纤连蛋白III型结构域（10Fn3）的抗体样蛋白。 本发明还涉及包含与用于诊断和治疗应用的异源蛋白质连接的血清白蛋白结合10Fn3的融合分子。
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公开(公告)号：US20110305663A1
公开(公告)日：2011-12-15
申请号：US13098851
申请日：2011-05-02
申请人： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
发明人： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
IPC分类号： A61K38/20 , C07K19/00 , A61K38/17 , A61P3/10 , A61P3/04 , A61K38/18 , A61K38/28 , A61K38/22 , A61K38/26 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/21 , A61P3/00 , A61P3/06 , A61P9/00 , C07K14/47
CPC分类号： C12P21/005 , A61K38/00 , A61K47/62 , A61K47/643 , C07K14/435 , C07K14/50 , C07K14/575 , C07K14/78 , C07K2319/70 , C12N15/62
摘要： The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
摘要翻译： 本发明涉及基于结合血清白蛋白的第十纤连蛋白III型结构域（10Fn3）的抗体样蛋白。 本发明还涉及包含与用于诊断和治疗应用的异源蛋白质连接的血清白蛋白结合10Fn3的融合分子。
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公开(公告)号：US09562089B2
公开(公告)日：2017-02-07
申请号：US13699458
申请日：2011-05-26
申请人： Ray Camphausen , John O'Loughlin , Bernice Yeung , Yihong Zhang
发明人： Ray Camphausen , John O'Loughlin , Bernice Yeung , Yihong Zhang
IPC分类号： C07K14/705 , C07K14/78 , C07K14/435 , C07K16/46 , A61K38/39 , A61K38/17 , A61K38/18 , C07K14/71 , C07K14/715 , C07K16/28
CPC分类号： C07K14/78 , A61K38/00 , C07K14/71 , C07K14/7155 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/94 , C07K2318/20 , C07K2319/00 , C07K2319/30
摘要： The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of fibronectin based scaffold proteins and the use thereof in diagnostic, research and therapeutic applications. The application further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising such polynucleotides.
摘要翻译： 本申请提供与改善的稳定性相关的基于纤连蛋白的支架蛋白。 该应用还涉及基于纤维连接蛋白的支架蛋白的稳定制剂及其在诊断，研究和治疗应用中的用途。 本申请还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含这种多核苷酸的载体。
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公开(公告)号：US08420098B2
公开(公告)日：2013-04-16
申请号：US13085864
申请日：2011-04-13
申请人： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
发明人： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC分类号： C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
摘要： The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
摘要翻译： 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这些蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US5840679A
公开(公告)日：1998-11-24
申请号：US472576
申请日：1995-06-07
申请人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw , Ray Camphausen
发明人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw , Ray Camphausen
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N9/10 , C12N9/64 , C12N15/12 , A61K38/16 , A61K39/395 , C07K16/00 , G01N33/53
CPC分类号： C12N9/6454 , C07K14/4703 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C12N9/10 , C12N9/1051 , A61K38/00 , A61K39/00 , C07K2317/34 , C07K2319/00 , C07K2319/24 , Y10S514/844 , Y10S514/937 , Y10S514/944
摘要： A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
摘要翻译： 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。
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