公开(公告)号：US07679745B2

公开(公告)日：2010-03-16

申请号：US11603939

申请日：2006-11-21

Applicant: Ricardo Claps ,  Bradley A. Smith

Inventor： Ricardo Claps ,  Bradley A. Smith

IPC: G01J3/30

CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/2889 ,  G01J3/4406

Abstract: A time-resolved, fluorescence spectrometer makes use of a RadiaLight® optical switch and no dispersive optical elements (DOE) like gratings. The structure is unique in its compactness and simplicity of operation. In one embodiment, the spectrometer makes use of only one photo-detector and an efficient linear regression algorithm. The structure offers a time resolution, for multiple species measurements, of less than 1 s. The structure can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

Abstract translation: 时间分辨的荧光光谱仪利用RadiaLight®光开关，不使用像光栅这样的色散光学元件（DOE）。 该结构在其紧凑性和操作简单性方面是独一无二的。 在一个实施例中，光谱仪仅使用一个光电检测器和有效的线性回归算法。 该结构提供时间分辨率，用于多种物种测量，小于1秒。 该结构也可用于进行荧光相关光谱和荧光互相关光谱。

公开(公告)号：US08554518B1

公开(公告)日：2013-10-08

申请号：US12726427

申请日：2010-03-18

Applicant: Ricardo Claps

Inventor： Ricardo Claps

IPC: H03F1/26 ,  H04B15/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/35

Abstract: A method for recognizing figures in an image frame provided by an optical device is disclosed. The method includes selecting a set of calibration images having characteristic figures; selecting a number of horizontal and vertical channels for dividing the image, obtaining a digital signature for the image corresponding to each channel to create a calibration image matrix, obtaining a first set of characteristics and a second set of characteristics from said calibration image matrix and selecting two coordinates from at least one component in each of said first and second sets of characteristics from said calibration image matrix; forming a pattern vector from said selected coordinates from at least one component in each of said first and second sets of characteristics from said calibration image matrix, forming a calibration pattern matrix using pattern vectors from a plurality of said calibration images, forming a sample pattern vector from said selected coordinates from at least one component in each of said first and second sets of characteristics from a sample image, obtaining a two-dimensional projection of the vector resulting from transforming a sample pattern vector by the calibration pattern matrix, and determining whether the sample figure corresponds to a calibration pattern by the location in a two-dimensional plot of said projection. A method for recognizing tissue conditions in a sample tissue image frame provided by an optical device using the pattern recognition as described above is also provided.

Abstract translation: 公开了一种用于识别由光学装置提供的图像帧中的图形的方法。 该方法包括选择具有特征图的一组校准图像; 选择用于划分图像的多个水平和垂直通道，获得与每个通道相对应的图像的数字签名以产生校准图像矩阵，从所述校准图像矩阵获得第一组特征和第二组特征，并选择 在来自所述校准图像矩阵的所述第一和第二特征集合中的每一个中的至少一个分量的两个坐标; 从所述校准图像矩阵从所述第一和第二特征集合中的每一个中的至少一个分量从所述选定的坐标形成图案向量，使用来自多个所述校准图像的模式向量形成校准图案矩阵，形成样本图案向量 从所述选定的坐标中，从所述第一和第二组特征中的每一个中的至少一个分量来自样本图像，获得由样本图案向量变换校准图案矩阵得到的向量的二维投影，以及确定是否 样本图对应于通过所述投影的二维图中的位置的校准图案。 还提供了一种用于识别由如上所述的模式识别的光学装置提供的样本组织图像帧中的组织条件的方法。

公开(公告)号：US07783458B2

公开(公告)日：2010-08-24

申请号：US11767458

申请日：2007-06-22

Applicant: Ricardo Claps

Inventor： Ricardo Claps

IPC: H03F1/26

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/359

Abstract: An optical system employs filtered broad band light for determining the specific components in a material sample. The system forms an r by n matrix C representing r principal components of the measurement to be analyzed at n different frequencies. Each sample contains a known quantity of the different materials in the sample being analyzed where r represents the number of different analytes or components in the sample. The system measures m different samples at n different frequencies, said m samples containing unknown quantities of the material, where “m” is a selected integer representing the number of samples. Using the measured results from the m samples the system forms an n by m matrix P, where P=C·R, and where R is an m by r matrix representing r unknown values of the r principal components which are being measured in the m material samples. The system then solves the equation P=C·R for R by inverting C in the equation R=(CT·C)−1·CT·P. This gives the value of each of the r principal components in the sample.

Abstract translation: 光学系统使用过滤的宽带光来确定材料样品中的特定组分。 该系统形成r个n矩阵C，表示将在n个不同频率下分析的测量的主要分量。 每个样品包含已分析样品中不同材料的数量，其中r表示样品中不同分析物或组分的数量。 该系统测量n个不同频率的不同样本，所述m个样本包含未知量的材料，其中“m”是表示样本数量的选定整数。 使用来自m个样本的测量结果，系统由m矩阵P形成n，其中P = C·R，并且其中R是由r矩阵表示的r矩阵，其表示在m中测量的r个主成分的未知值 材料样品。 系统然后通过在等式R =（CT·C）-1·CT·P中反转C求解方程P = C·R。 这给出了样本中每个主要成分的值。

公开(公告)号：US20080117418A1

公开(公告)日：2008-05-22

申请号：US11603939

申请日：2006-11-21

Applicant: Ricardo Claps ,  Bradley A. Smith

Inventor： Ricardo Claps ,  Bradley A. Smith

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/2889 ,  G01J3/4406

Abstract: A time-resolved, fluorescence spectrometer makes use of a RadiaLight® optical switch and no dispersive optical elements (DOE) like gratings. The structure is unique in its compactness and simplicity of operation. In one embodiment, the spectrometer makes use of only one photo-detector and an efficient linear regression algorithm. The structure offers a time resolution, for multiple species measurements, of less than 1 s. The structure can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

Abstract translation: 时间分辨的荧光光谱仪利用RadiaLight（R）光学开关，而不使用像光栅这样的色散光学元件（DOE）。 该结构在其紧凑性和操作简单性方面是独一无二的。 在一个实施例中，光谱仪仅使用一个光电检测器和有效的线性回归算法。 该结构提供时间分辨率，用于多种物种测量，小于1秒。 该结构也可用于进行荧光相关光谱和荧光互相关光谱。

公开(公告)号：US07602488B2

公开(公告)日：2009-10-13

申请号：US11452129

申请日：2006-06-12

Applicant: Ricardo Claps ,  Bradley A. Smith

Inventor： Ricardo Claps ,  Bradley A. Smith

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/2889 ,  G01J3/32 ,  G01J2003/123 ,  G01N21/65

Abstract: A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. The system additionally is compact, environmentally rugged, low cost and can detect multiple components of a sample simultaneously. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple bandpass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.The combination of time-multiplexing the input signal through multiple optical filters and time-sequencing the optical detector enables the device to detect and analyze 2-3 orders of magnitude faster than current designs, processing spectra within milliseconds instead of seconds. The system can process multiple material samples (25+) simultaneously, instead of sequentially, and its mechanical ruggedness and simplicity enables using the system in harsh physical environments when traditional spectrometers can not be used reliably.

Abstract translation: 实现时间分辨拉曼光谱仪的新架构比现有系统快2-3个数量级。 该系统还具有结构紧凑，环境坚固，成本低，可同时检测样品的多个成分。 在一个实施例中，本发明采用旋转光学开关来将输入信号经过多个带通滤波器进行时间复用，并进入单个光学检测器，只有当滤波后的输入光脉冲即将影响时才能电激活。 通过多个光学滤波器对输入信号进行时间复用和对光学检测器进行时间排序的组合使得该器件能够比目前的设计更快地检测和分析2-3个数量级，在几毫秒而不是几秒内处理光谱。 该系统可以同时处理多个材料样品（25+），而不是依次加工，并且其机械坚固性和简单性使得在传统光谱仪不能可靠地使用恶劣的物理环境中使用该系统。

公开(公告)号：US20070285658A1

公开(公告)日：2007-12-13

申请号：US11452129

申请日：2006-06-12

Applicant: Ricardo Claps ,  Bradley A. Smith

Inventor： Ricardo Claps ,  Bradley A. Smith

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/2889 ,  G01J3/32 ,  G01J2003/123 ,  G01N21/65

Abstract: A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. The system additionally is compact, environmentally rugged, low cost and can detect multiple components of a sample simultaneously. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple bandpass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.The combination of time-multiplexing the input signal through multiple optical filters and time-sequencing the optical detector enables the device to detect and analyze 2-3 orders of magnitude faster than current designs, processing spectra within milliseconds instead of seconds. The system can process multiple material samples (25+) simultaneously, instead of sequentially, and its mechanical ruggedness and simplicity enables using the system in harsh physical environments when traditional spectrometers can not be used reliably.

Abstract translation: 实现时间分辨拉曼光谱仪的新架构比现有系统快2-3个数量级。 该系统还具有结构紧凑，环境坚固，成本低，可同时检测样品的多个成分。 在一个实施例中，本发明采用旋转光学开关来将输入信号经过多个带通滤波器进行时间复用，并进入单个光学检测器，只有当滤波后的输入光脉冲即将影响时才能电激活。 通过多个光学滤波器对输入信号进行时间复用和对光学检测器进行时间排序的组合使得该器件能够比目前的设计更快地检测和分析2-3个数量级，在几毫秒而不是几秒内处理光谱。 该系统可以同时处理多个材料样品（25+），而不是依次加工，并且其机械坚固性和简单性使得在传统光谱仪不能可靠地使用恶劣的物理环境中使用该系统。

公开(公告)号：US08405827B2

公开(公告)日：2013-03-26

申请号：US12697227

申请日：2010-01-30

Applicant: Ricardo Claps

Inventor： Ricardo Claps

IPC: G01J3/30

CPC classification number: G01N21/64 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/2889 ,  G01J3/4406 ,  G01N21/6408 ,  G06F17/10

Abstract: A time-resolved spectroscopy system employing a time-division multiplexing optical device with no dispersive optical elements to perform lifetime and concentration measurements in multi-species samples, is disclosed. Some examples include fluorescence and cavity ring-down spectroscopy. The system is unique in its compactness and simplicity of operation. In one embodiment, the system makes use of only one photo-detector and an efficient linear regression algorithm. The system offers a measurement time for multiple species measurements of less than 1 s. The system can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Four methods to de-convolve a multi-component, exponentially decaying optical signal such as obtained with the system disclosed here, are presented. These methods may be applied to the measurement of fluorescence decay lifetimes and cavity ring-down times, the latter used extensively for the measurement of gas and trace-gas concentrations in complex mixtures, via absorption spectroscopy.

公开(公告)号：US07944555B2

公开(公告)日：2011-05-17

申请号：US12551404

申请日：2009-08-31

Applicant: Ricardo Claps

Inventor： Ricardo Claps

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/2889 ,  G01J3/32 ,  G01J2003/123 ,  G01N21/65

Abstract: A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple band-pass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.Time-multiplexing the input signal through multiple optical filters and time-sequencing the optical detector enables the device to detect and analyze 2-3 orders of magnitude faster than current designs. In one embodiment, the system may be employed for the diagnostics of a pathological condition of skin tissue in patients, such as malignant melanoma or other types of skin cancers and abnormal conditions.

Abstract translation: 实现时间分辨拉曼光谱仪的新架构比现有系统快2-3个数量级。 在一个实施例中，本发明采用旋转光开关，通过多个带通滤波器对输入信号进行时间复用，并将其转换成仅在滤波后的输入光脉冲即将影响时才被电激活的单个光检测器。 通过多个光学滤波器对输入信号进行时分复用，并对光学检测器进行时间排序，使器件能够比目前的设计更快地检测和分析2-3个数量级。 在一个实施方案中，该系统可用于诊断患者皮肤组织的病理状况，例如恶性黑素瘤或其他类型的皮肤癌症和异常状况。

公开(公告)号：US20100165338A1

公开(公告)日：2010-07-01

申请号：US12697227

申请日：2010-01-30

Applicant: Ricardo Claps

Inventor： Ricardo Claps

IPC: G01J3/30

CPC classification number: G01N21/64 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/2889 ,  G01J3/4406 ,  G01N21/6408 ,  G06F17/10

Abstract: A time-resolved spectroscopy system employing a time-division multiplexing optical device with no dispersive optical elements to perform lifetime and concentration measurements in multi-species samples, is disclosed. Some examples include fluorescence and cavity ring-down spectroscopy. The system is unique in its compactness and simplicity of operation. In one embodiment, the system makes use of only one photo-detector and an efficient linear regression algorithm. The system offers a measurement time for multiple species measurements of less than 1 s. The system can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Four methods to de-convolve a multi-component, exponentially decaying optical signal such as obtained with the system disclosed here, are presented. These methods may be applied to the measurement of fluorescence decay lifetimes and cavity ring-down times, the latter used extensively for the measurement of gas and trace-gas concentrations in complex mixtures, via absorption spectroscopy.

Abstract translation: 公开了一种使用没有色散光学元件的时分复用光学器件来执行多品种样品中的寿命和浓度测量的时间分辨光谱系统。 一些实例包括荧光和空腔衰减光谱。 该系统具有独特的紧凑性和操作简单性。 在一个实施例中，系统仅使用一个光电检测器和有效的线性回归算法。 该系统为少于1秒的多种物种测量提供测量时间。 该系统还可用于进行荧光相关光谱和荧光互相关光谱。 提出了四种解卷积多分量指数衰减光信号的方法，例如用这里公开的系统获得的。 这些方法可以应用于荧光衰减寿命和空腔衰减时间的测量，后者广泛用于通过吸收光谱测量复杂混合物中的气体和痕量气体浓度。