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1.发明授权Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, a pyridyl group and an alkyl group, having retinoid-like biological activity 失效被二氢萘基，色烯基或硫代色烯基取代的胺，吡啶基和烷基，具有类视黄醇样生物活性公开(公告)号：US07026487B2
公开(公告)日：2006-04-11
申请号：US10612667
申请日：2003-07-02
申请人： Richard L. Beard , Thong Vu , Diana F. Colon , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Richard L. Beard , Thong Vu , Diana F. Colon , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： C07D213/74 , C07D407/12 , C07D409/12
CPC分类号： C07D335/06 , C07C229/60 , C07C2602/10 , C07D311/20
摘要： Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.
摘要翻译： 其中符号如说明书中所定义的式的化合物具有类视黄醇激动剂，拮抗剂或负激素样生物活性。
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2.发明授权Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity 失效被二氢萘基，色烯基或硫代色烯基，芳基或杂芳基和烷基取代的胺具有类视黄醇样生物活性公开(公告)号：US06613917B1
公开(公告)日：2003-09-02
申请号：US09533680
申请日：2000-03-23
申请人： Richard L. Beard , Thong Vu , Diana F. Colon , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Richard L. Beard , Thong Vu , Diana F. Colon , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： C07D31104
CPC分类号： C07D335/06 , C07C229/60 , C07C2602/10 , C07D311/20
摘要： Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.
摘要翻译： 符号如本说明书中所定义的化合物具有类视黄醇激动剂，拮抗剂或负性激素样生物活性。
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公开(公告)号：US6166244A
公开(公告)日：2000-12-26
申请号：US307061
申请日：1999-05-07
IPC分类号： A61K31/325 , A61P17/00 , C07C69/52 , C07C69/76 , C07C69/84 , C07C69/86 , C07C333/00 , C07C403/18 , C07D213/06 , C07D237/02 , C07D333/16 , C07F7/08 , C07C69/64
CPC分类号： C07C403/02 , C07C69/76 , C07C2601/14 , C07F7/081 , C07F7/0812
摘要： Compounds of the Formula 1, Formula 2, Formula 3 and Formula 4 wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity. ##STR1##
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4.发明授权1-alkoxy and 1-acyloxy substituted cyclohex-1-ene compounds and sulfur and 1-alkoxycarbonyl analogs having retinoid-like biological activity 失效1-烷氧基和1-酰氧基取代的环己-1-烯化合物和具有类视黄醇样生物活性的硫和1-烷氧基羰基类似物公开(公告)号：US06177588B1
公开(公告)日：2001-01-23
申请号：US09307073
申请日：1999-05-07
IPC分类号： C07C6976
CPC分类号： C07C403/02 , C07C69/76 , C07C2601/16 , C07F7/081 , C07F7/0812 , C07F7/1804
摘要： Compounds of Formula 1 and of Formula 2 where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid negative hormone like biological activity.
摘要翻译： 符号具有本说明书中定义的含义的式1和式2的化合物具有类视黄醇，维生素A拮抗剂或类视黄醇阴性激素，如生物活性。
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5.发明授权N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity 失效具有类视黄醇激动剂的N-芳基取代的四氢喹啉类，类视黄醇拮抗剂或类视色素反向激动剂型生物活性
公开(公告)号：US5739338A
公开(公告)日：1998-04-14
申请号：US744210
申请日：1996-11-05
IPC分类号： C07D215/22 , A61K31/47 , A61K31/695 , A61P1/00 , A61P3/06 , A61P17/00 , A61P25/00 , A61P27/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07D215/06 , C07D215/12 , C07D215/18 , C07D215/227 , C07D215/48 , C07F7/10
CPC分类号： C07D215/227 , C07D215/06 , C07D215/12 , C07D215/18 , C07D215/48
摘要： Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid inverse agonist-like biological activity.
摘要翻译： 符号具有本说明书中定义的含义的式“IMAGE”的化合物具有类视黄醇，维生素A拮抗剂或类视黄醇反向激动剂样生物活性。
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6.发明授权Oxygen, sulfur and nitrogen substituted cyclohexene and cyclohexane derivatives having retinoid-like biological activity 失效氧，硫和氮取代的环己烯和具有类视黄醇样生物活性的环己烷衍生物公开(公告)号：US06465647B1
公开(公告)日：2002-10-15
申请号：US09634727
申请日：2000-08-04
IPC分类号： C07D23702
CPC分类号： C07C403/02 , C07C69/76 , C07C2601/14 , C07F7/081 , C07F7/0812
摘要： Compounds of the Formula 1, Formula 2, Formula 3 and Formula 4 wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity.
摘要翻译： 式1，式2，式3和式4的化合物，其中符号具有本公开中赋予它们的含义具有类视色素样生物活性。
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7.发明授权Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity 失效被四氢喹啉基取代为具有类视黄醇样生物活性的芳基或杂芳基和烷基的胺
公开(公告)号：US6127382A
公开(公告)日：2000-10-03
申请号：US375846
申请日：1999-08-16
IPC分类号： A61K31/47 , A61K31/4704 , A61P1/00 , A61P1/04 , A61P3/06 , A61P3/10 , A61P5/06 , A61P5/44 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07D215/38 , C07D215/00 , C07D215/16 , C07D215/20 , C07D401/00
CPC分类号： C07D215/38
摘要： Compound of Formula 1 ##STR1## where the symbols have the meaning described in the specification, have retinoid-like biological activity.
摘要翻译： 符号具有说明书中描述的含义的式1化合物具有类视黄醇样生物活性。
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8.发明授权1-alkoxy and 1-acyloxy substituted cyclohex-1-ene compounds and sulfur and 1-alkoxycarbonyl analogs having retinoid-like biological activity 失效1-烷氧基和1-酰氧基取代的环己-1-烯化合物和具有类视黄醇样生物活性的硫和1-烷氧基羰基类似物公开(公告)号：US06465646B1
公开(公告)日：2002-10-15
申请号：US09634726
申请日：2000-08-04
IPC分类号： C07D23702
CPC分类号： C07C403/02 , C07C69/76 , C07C2601/16 , C07F7/081 , C07F7/0812 , C07F7/1804
摘要： Compounds of Formula 1 and of Formula 2 where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid negative hormone like biological activity.
摘要翻译： 符号具有本说明书中定义的含义的式1和式2的化合物具有类视黄醇，维生素A拮抗剂或类视黄醇阴性激素，如生物活性。
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9.发明授权Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity 失效用四氢萘基，苯并二氢吡喃基，硫代苯并二氢吡喃基或四氢喹啉基和取代的苯基或杂芳基二取代的硫化物，亚砜和砜，具有类视黄醇样生物活性
公开(公告)号：US5672710A
公开(公告)日：1997-09-30
申请号：US552965
申请日：1995-11-03
IPC分类号： C07C317/44 , C07C323/62 , C07D213/80 , C07D277/36 , C07D277/56 , C07D277/24
CPC分类号： C07D213/80 , C07C317/44 , C07C323/62 , C07D277/56
摘要： ##STR1## wherein the symbols have the meaning described in the specification, are selective agonists of RXR retinoid receptors.
摘要翻译： 其中符号具有说明书中描述的含义，是RXR类视黄醇受体的选择性激动剂。
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10.发明授权Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity 有权吲哚-3-羧酸酰胺，酯，硫代酰胺和含有具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的芳基或杂芳基的硫醇酯化合物公开(公告)号：US07737173B2
公开(公告)日：2010-06-15
申请号：US11675168
申请日：2007-02-15
申请人： Richard L. Beard , John E. Donello , Haiqing Yuan , Diana F. Colon , Tien Duong , Xiaoxia Liu , Yihui Hu
发明人： Richard L. Beard , John E. Donello , Haiqing Yuan , Diana F. Colon , Tien Duong , Xiaoxia Liu , Yihui Hu
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： A61K31/405 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , A61K31/675 , C07D209/42
摘要： The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, A, X, Z, R1, o, R3, R2 and p are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
摘要翻译： 本发明提供了由式I表示的化合物，其中每一种化合物可具有鞘氨醇-1-磷酸受体激动剂和/或拮抗剂生物学活性，其中变量Y，R4，n，A，X，Z，R1，o，R3 ，R2和p如说明书中所定义。 这些化合物可用于治疗选自青光眼，干眼症，血管发生，心血管疾病和疾病以及伤口愈合的疾病或病症。
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