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公开(公告)号：US11940427B2
公开(公告)日：2024-03-26
申请号：US17448063
申请日：2021-09-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Benjamin Tiemann , Stefan Quint , Florian Schweinberger
CPC classification number: G01N30/7266 , G01N30/88 , G01N2030/027
Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current. The controller is further configured to carry out adjusting detection conditions of one or more of the multiple fluidic streams responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream to be detected by the mass spectrometer in the respective detection time window.
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公开(公告)号：US20230321660A1
公开(公告)日：2023-10-12
申请号：US18335608
申请日：2023-06-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Faigle , Thomas Heinemeyer , Florian Schweinberger , Roland Thiele
IPC: B01L3/00
CPC classification number: B01L3/5082 , B01L2300/023 , B01L2300/0663 , B01L2300/0832 , B01L2300/024
Abstract: A reaction vessel for a diagnostic analyzer comprising a plurality of processing stations. The reaction vessel comprises at least one sensor configured to measure at least one physical parameter associated with at least one of the processing stations of the diagnostic analyzer when disposed at the at least one of the processing stations, a memory configured to at least temporarily store at least one measurement value indicating the physical parameter provided by the sensor, a processing unit configured to control the sensor and to output measurement data including the measurement value from the memory, an interface configured to provide communication of the processing unit with an external electronic device, a power source configured to supply electric power to the sensor, the processing unit and the memory. The reaction vessel defines an internal volume. The sensor, the processing unit, the memory and the interface are arranged within the internal volume.
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公开(公告)号：US12165859B2
公开(公告)日：2024-12-10
申请号：US17653539
申请日：2022-03-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Florian Schweinberger
IPC: H01J49/00
Abstract: A method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the MS and automatically processing the sample, performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode, or at least a first full scan measurement for a first mass filter and a second full scan measurement for a second mass filter; comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a condition is out of specification based on a result of the comparing steps.
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公开(公告)号：US20210063361A1
公开(公告)日：2021-03-04
申请号：US16994118
申请日：2020-08-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Benjamin Tiemann , Florian Schweinberger , Martin Stingl
Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
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公开(公告)号：US20220128531A1
公开(公告)日：2022-04-28
申请号：US17448063
申请日：2021-09-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Benjamin Tiemann , Stefan Quint , Florian Schweinberger
Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current. The controller is further configured to carry out adjusting detection conditions of one or more of the multiple fluidic streams responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream to be detected by the mass spectrometer in the respective detection time window.
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Patent Agency Ranking
公开(公告)号：US11287402B2
公开(公告)日：2022-03-29
申请号：US17113164
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Marian Roetzer , Florian Schweinberger , Benjamin Tiemann , Marius Wagner , Ralf Zimmermann
Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
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公开(公告)号：US11249059B2
公开(公告)日：2022-02-15
申请号：US16994118
申请日：2020-08-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Benjamin Tiemann , Florian Schweinberger , Martin Stingl
IPC: G01N30/72 , G01N30/86 , H01J49/00 , H01J49/16 , G01N35/10 , H01J49/04 , G01N30/62 , G01N15/12 , G01N30/04
Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
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公开(公告)号：US20250069875A1
公开(公告)日：2025-02-27
申请号：US18719252
申请日：2022-12-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Florian Schweinberger , Benjamin Tiemann , Marius Wagner
IPC: H01J49/00
Abstract: A method for characterization of a mass spectrometry instrument (100) comprising at least one mass analyzing cell (102, 104, 106) is proposed. The method comprising the steps of analyzing a sample (110) comprising at least one substance having a known molecular weight by means of the mass spectrometry instrument (100) so as to provide a mass spectrum (116, 118, 144, 146) of the sample (110), determining an outer envelope and an inner envelope of the mass spectrum (116, 118, 144, 146), calculating a squared difference between the outer envelope and the inner envelope, and determining a deviation of the calculated squared difference from a theoretical mass to charge ratio value of the substance.
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公开(公告)号：US20220172940A1
公开(公告)日：2022-06-02
申请号：US17453189
申请日：2021-11-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Florian Schweinberger
Abstract: A packaging for a needle-like component of a mass spectrometry (MS) system is provided. The packaging includes a receptacle configured for storing the needle-like component in a secured position inside the receptacle. The packaging further comprises an actuator configured to move the needle-like component from the secured position inside the receptacle to a mounting position in which the needle-like component projects out of the receptacle for mounting the needle-like component to the MS system.
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公开(公告)号：US12255059B2
公开(公告)日：2025-03-18
申请号：US17805482
申请日：2022-06-06
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Florian Schweinberger , Benjamin Tiemann
IPC: H01J49/42
Abstract: A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer is provided and comprises at least one voltage application step, wherein a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes of at least one mass filter of the analyzer, wherein the AC voltage has an amplitude VAC and the DC voltage has an applicable voltage VDC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ΔVDC of the supplementary AC voltage is ≤ V DC , max 2 b + 1 , wherein VDC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board of the mass filter of the analyzer; and wherein at least one transition of the analyte is determined with at least one detector of the analyzer.
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