公开(公告)号：US20230333123A1

公开(公告)日：2023-10-19

申请号：US18337018

申请日：2023-06-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marius Fraefel ,  Stefanie Grimm ,  Thomas Hoffmann

IPC: G01N33/74 ,  G01N30/72

CPC classification number: G01N33/743 ,  G01N30/7233

Abstract: The present invention relates to a method for detecting and/or quantifying one or more steroids using mass spectrometry, said steroids comprising at least one 11-oxygenated steroids. The method of the invention comprises (i) extracting the one or more steroids from the sample using solid phase extraction (SPE) so as to obtain an SPE extract comprising the one or more steroids; (ii) concentrating the one or more steroids, said concentrating comprising evaporating solvent from the SPE-extract; and (iii) detecting or quantifying the one or more steroids in the sample using mass spectrometry.

公开(公告)号：US20230127289A1

公开(公告)日：2023-04-27

申请号：US17990714

申请日：2022-11-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Robert Hahn ,  Dieter Heindl ,  Thomas Hoffmann ,  Hans-Peter Josel ,  Uwe Kobold ,  Hannes Kuchelmeister ,  Simon Ferdinand Loibl ,  Daniela Mazzier ,  Jelena Milic ,  Giuseppe Prencipe ,  Martin Rempt ,  Christoph Seidel

IPC: C07D213/56 ,  C07D401/04 ,  C07D213/74 ,  C07D213/30 ,  H01J49/00

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

公开(公告)号：US20230333069A1

公开(公告)日：2023-10-19

申请号：US18337020

申请日：2023-06-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Hoffmann ,  Peter Kupser ,  Andreas Leinenbach ,  Indranil Mitra ,  Jatin Nandania ,  Cornelia Werner

IPC: G01N30/12 ,  G01N30/72

CPC classification number: G01N30/12 ,  G01N30/7233 ,  G01N2030/027

Abstract: The present invention relates to a method for detecting and/or quantifying an analyte in a sample using mass spectrometry. The method of the invention comprises: extracting the analyte from the sample using solid phase extraction (SPE) so as to obtain an SPE extract comprising the analyte, concentrating the analyte, said concentrating comprising evaporating solvent from the SPE-extract; and detecting and/or quantifying the analyte in the sample using mass spectrometry.