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公开(公告)号：US20240400672A1
公开(公告)日：2024-12-05
申请号：US18662694
申请日：2024-05-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Gerg , Klaus Hirzel , Caroline Dorothea Hojer , Hans-Peter Josel , Ute Jucknischke , Holger Lehmann , Anastasia Markina , Giuseppe Prencipe , Leopold von Proff , Michael Schraeml , Steinar Halldórsson
Abstract: The present invention provides a novel monoclonal antibody specifically binding to L-Thyroxine (T4) and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such monoclonal antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such monoclonal antibodies. The monoclonal antibody of the invention comprises a heavy chain variable domain (VH) comprising V or A in position 33; Y in position 50; W in position 52; I in position 98, G, A or V in position 99; Y in position 100; and I in position 100b; and a light chain variable domain (VL) comprising amino acids H or Y in position 28; N or K in position 29; W in position 32; G or A in position 91; Y, W or F in position 92; S or T in position 93; Y or F in position 95b; N, S, T or Q in position 95c; and H in position 96, wherein the positions of the amino acids in the VH and the VL are indicated according to the Kabat numbering scheme, respectively.
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公开(公告)号：US20230127289A1
公开(公告)日：2023-04-27
申请号：US17990714
申请日：2022-11-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Hahn , Dieter Heindl , Thomas Hoffmann , Hans-Peter Josel , Uwe Kobold , Hannes Kuchelmeister , Simon Ferdinand Loibl , Daniela Mazzier , Jelena Milic , Giuseppe Prencipe , Martin Rempt , Christoph Seidel
IPC: C07D213/56 , C07D401/04 , C07D213/74 , C07D213/30 , H01J49/00
Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.
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公开(公告)号：US20240092742A1
公开(公告)日：2024-03-21
申请号：US18500149
申请日：2023-11-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
CPC classification number: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20210188788A1
公开(公告)日：2021-06-24
申请号：US17154501
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Robert Hahn , Nicole Pirkl
IPC: C07D257/04 , C07D249/06 , H01J49/00
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US11845733B2
公开(公告)日：2023-12-19
申请号：US17155020
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , C07D249/06 , C07D203/04 , G01N30/72
CPC classification number: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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Patent Agency Ranking
公开(公告)号：US20230324398A1
公开(公告)日：2023-10-12
申请号：US17990903
申请日：2022-11-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Uwe Kobold , Hannes Kuchelmeister , Heribert Maerz , Giuseppe Prencipe , Martin Rempt
IPC: G01N33/58
CPC classification number: G01N33/58 , G01N2560/00
Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.
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公开(公告)号：US20210140983A1
公开(公告)日：2021-05-13
申请号：US17155054
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: G01N33/74 , C07D401/06 , G01N33/58
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20230160904A1
公开(公告)日：2023-05-25
申请号：US17991366
申请日：2022-11-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Hahn , Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Hannes Kuchelmeister , Simon Loibl , Heribert Maerz , Giuseppe Prencipe , Martin Rempt
IPC: G01N33/68 , C07C243/34 , C07D401/04 , C07D213/55 , C07D213/74 , C07D213/56
CPC classification number: G01N33/6848 , C07C243/34 , C07D401/04 , C07D213/55 , C07D213/74 , C07D213/56 , G01N2560/00
Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.
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公开(公告)号：US11267827B2
公开(公告)日：2022-03-08
申请号：US16284346
申请日：2019-02-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Tobias Oelschlaegel , Giuseppe Prencipe , Luisa De Cola , Elena Longhi , Chien-Wei Hsu
Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
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公开(公告)号：US20210198217A1
公开(公告)日：2021-07-01
申请号：US17155020
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/06 , C07D257/04 , C07D203/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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