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    Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction
    1.
    发明授权
    Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction 失效
    酰腙衍生物及其在抑制，调节和/或调节激酶信号转导中的用途

    公开(公告)号：US07405239B2

    公开(公告)日：2008-07-29

    申请号：US10574781

    申请日：2004-09-16

    申请人： Rolf Gericke ,  Norbert Beier ,  Oliver Poeschke ,  Lars Burgdorf ,  Helga Drosdat ,  Florian Lang

    发明人： Rolf Gericke ,  Norbert Beier ,  Oliver Poeschke ,  Lars Burgdorf ,  Helga Drosdat ,  Florian Lang

    IPC分类号： C07C251/86 ,  A61K31/15

    CPC分类号： C07C251/86

    摘要： The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: R1 and R5 independently of one another represent H, OH, OA, OAc or methyl; R2, R3, R4, R6, R7, R8, R9 and R10 independently of one another represent H, OH, OA, OAc, OCF3, Hal, NO2, CF3, A, CN, OSO2CH3, SO2CH3, NH2, or COOH; R11 represents H or CH3; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH2, CH2CH2, OCH2 or —CH(OH)— and Hal represents F, Cl, Br or I.

    摘要翻译： 本发明涉及式（I）的酰腙衍生物，其为SGK抑制剂，可用于治疗与SGK相关的疾病和病症，如糖尿病，肥胖，代谢综合征（血脂异常），系统性和肺性高血压，心血管疾病 和肾脏疾病，一般用于所有类型的纤维和炎症过程。 在所述式中：R 1和R 5彼此独立地表示H，OH，OA，OAc或甲基; R 2，R 3，R 4，R 6，R 7， R 9，R 9和R 10彼此独立地表示H，OH，OA，OAc，OCF 3， >，Hal，NO 2，CF 3，A，CN，OSO 2，CH 3，SO， > 2个CH 3，NH 2或COOH; R 11表示H或CH 3; A表示包含1,2,3或4个C原子的烷基; X表示CH 2 CH 2，CH 2 CH 2，OCH 2或-CH（OH） - ，Hal表示 F，Cl，Br或I.

    ACYLHYDRAZONE DERIVATIVES AND THE USE THEREOF IN THE INHIBITION, REGULATION AND/OR MODULATION OF KINASE SIGNAL TRANSDUCTION
    2.
    发明申请
    ACYLHYDRAZONE DERIVATIVES AND THE USE THEREOF IN THE INHIBITION, REGULATION AND/OR MODULATION OF KINASE SIGNAL TRANSDUCTION 审中-公开
    ACYLHYDRAZONE衍生物及其在抑制，调节和/或调节激酶信号转导中的用途

    公开(公告)号：US20080214674A1

    公开(公告)日：2008-09-04

    申请号：US12100987

    申请日：2008-04-10

    申请人： Rolf Gericke ,  Norbert Beier ,  Oliver Poeschke ,  Lars Burgdorf ,  Helga Drosdat ,  Florian Lang

    发明人： Rolf Gericke ,  Norbert Beier ,  Oliver Poeschke ,  Lars Burgdorf ,  Helga Drosdat ,  Florian Lang

    IPC分类号： A61K31/165 ,  C07C251/86 ,  A61P3/10 ,  A61P3/04 ,  A61P9/00 ,  A61P35/00

    CPC分类号： C07C251/86

    摘要： Acylhydrazone derivatives of the formula (I) are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in any type of fibrosis and inflammatory process. In which R1, R5 each, independently of one another, H, OH, OA, OAc or methyl, R2, R3, R4, R6, R7, R8, R9, R10 each, independently of one another, H, OH, OA, OAc, OCF3, Hal, NO2, CF3, A, CN, OSO2CH3, SO2CH3, NH2 or COOH, R11H or CH3, A alkyl having 1, 2, 3 or 4 C atoms, X CH2, CH2CH2, OCH2 or —CH(OH)—, Hal F, Cl, Br or I.

    摘要翻译： 式（I）的酰腙衍生物是SGK抑制剂，可用于治疗SGK诱发的疾病和病症，例如糖尿病，肥胖，代谢综合征（血脂异常），全身和肺性高血压，心血管疾病和肾脏疾病 在任何类型的纤维化和炎症过程。 其中R 1，R 5各自独立地为H，OH，OA，OAc或甲基，R 2，R 2， R 4，R 4，R 6，R 7，R 8，R 8， 各自独立地为H，OH，OA，OAc，OCF 3，Hal，NO 2， / SUB>，CF 3，A，CN，OSO 2，CH 3，SO 2，CH 2， 3，NH 2或COOH，R 11 H或CH 3，具有1,2,3或4个碳原子的烷基 原子，X CH 2，CH 2 CH 2，OCH 2或-CH（OH） - ，Hal F，Cl，Br或I.

    Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction
    3.
    发明申请
    Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction 失效
    酰腙衍生物及其在抑制，调节和/或调节激酶信号转导中的用途

    公开(公告)号：US20070060646A1

    公开(公告)日：2007-03-15

    申请号：US10574781

    申请日：2004-09-16

    申请人： Rolf Gericke ,  Norbert Beier ,  Oliver Poeschke ,  Lars Burgdorf ,  Helga Drosdat ,  Florian Lang

    发明人： Rolf Gericke ,  Norbert Beier ,  Oliver Poeschke ,  Lars Burgdorf ,  Helga Drosdat ,  Florian Lang

    IPC分类号： A61K31/277 ,  A61K31/22 ,  A61K31/165

    CPC分类号： C07C251/86

    摘要： The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: R1 and R5 independently of one another represent H, OH, OA, OAc or methyl; R2, R3, R4, R6, R7, R8, R9 and R10 independently of one another represent H, OH, OA, OAc, OCF3, Hal, NO2, CF3, A, CN, OSO2CH3, SO2CH3, NH2, or COOH; R11 represents H or CH3; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH2, CH2CH2, OCH2 or —CH(OH)— and Hal represents F, Cl, Br or I.

    摘要翻译： 本发明涉及式（I）的酰腙衍生物，其为SGK抑制剂，可用于治疗与SGK相关的疾病和病症，如糖尿病，肥胖，代谢综合征（血脂异常），系统性和肺性高血压，心血管疾病 和肾脏疾病，一般用于所有类型的纤维和炎症过程。 在所述式中：R 1和R 5彼此独立地表示H，OH，OA，OAc或甲基; R 2，R 3，R 4，R 6，R 7， R 9，R 9和R 10彼此独立地表示H，OH，OA，OAc，OCF 3， >，Hal，NO 2，CF 3，A，CN，OSO 2，CH 3，SO， > 2个CH 3，NH 2或COOH; R 11表示H或CH 3; A表示包含1,2,3或4个C原子的烷基; X表示CH 2 CH 2，CH 2 CH 2，OCH 2或-CH（OH） - ，Hal表示 F，Cl，Br或I.