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1.发明授权公开(公告)号：US10246507B2
公开(公告)日：2019-04-02
申请号：US14869636
申请日：2015-09-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun Lee , Soo Yeon Jung , Bo Gyou Kim , Seung Ja Oh , Ji Min Lee
IPC: A61K39/395 , C07K16/22 , C07K16/28 , C07K16/30
Abstract: A polypeptide, an anti-VEGF antibody and an anti-c-Met/anti-VEGF bispecific antibody, which includes the polypeptide, a pharmaceutical composition including the antibody, and a method of treating cancer using the antibody.
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公开(公告)号：US10578621B2
公开(公告)日：2020-03-03
申请号：US14814165
申请日：2015-07-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ji Min Lee , Bo Gyou Kim , Kyung Ah Kim , Seung Ja Oh
IPC: G01N33/574 , C07K16/30
Abstract: A biomarker PNCK for predicting an efficacy of a dual-targeting agent that targets both c-Met and EGFR and a method of predicting an effect of a dual-targeting agent that targets both c-Met and EGFR, selecting the subject for application of a dual-targeting agent that targets both c-Met and EGFR, or monitoring an effect of a dual-targeting agent that targets both c-Met and EGFR, including measuring a level of a PNCK and/or a PNCK coding gene.
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公开(公告)号：US20180086825A1
公开(公告)日：2018-03-29
申请号：US15823272
申请日：2017-11-27
Applicant: Samsung Electronics Co., Ltd
Inventor： Kyung Eun Kim , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
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公开(公告)号：US09902767B2
公开(公告)日：2018-02-27
申请号：US14446256
申请日：2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hyo Seon Lee , Kyung Eun Kim , Seung Ja Oh , Sang Yeul Han
IPC: A61K39/395 , C07K16/22 , A61K38/18 , G01N33/74 , A61K39/00
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: A method for the prevention and/or treatment of a disease accompanied by vascular leakage and/or vascular inflammation comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and forms a complex with a Tie2 receptor and Ang2.
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5.发明申请公开(公告)号：US20160033518A1
公开(公告)日：2016-02-04
申请号：US14814165
申请日：2015-07-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ji Min Lee , Bo Gyou Kim , Kyung Ah Kim , Seung Ja Oh
IPC: G01N33/574 , C07K16/30 , C07K16/40
CPC classification number: G01N33/57496 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N2333/91205
Abstract: A biomarker PNCK for predicting an efficacy of a dual-targeting agent that targets both c-Met and EGFR and a method of predicting an effect of a dual-targeting agent that targets both c-Met and EGFR, selecting the subject for application of a dual-targeting agent that targets both c-Met and EGFR, or monitoring an effect of a dual-targeting agent that targets both c-Met and EGFR, including measuring a level of a PNCK and/or a PNCK coding gene.
Abstract translation: 用于预测靶向c-Met和EGFR的双靶向药物的功效的生物标志物PNCK和预测靶向c-Met和EGFR的双靶向药物的作用的方法，选择受试者应用 靶向c-Met和EGFR的双重靶向剂，或监测靶向c-Met和EGFR的双重靶向剂的作用，包括测量PNCK和/或PNCK编码基因的水平。
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Patent Agency Ranking
公开(公告)号：US20150030604A1
公开(公告)日：2015-01-29
申请号：US14446256
申请日：2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hyo Seon LEE , Kyung Eun Kim , Seung Ja Oh , Sang Yeul Han
IPC: C07K16/22 , A61K39/395 , A61K38/18
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: A method for the prevention and/or treatment of a disease accompanied by vascular leakage and/or vascular inflammation comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and forms a complex with a Tie2 receptor and Ang2.
Abstract translation: 一种用于预防和/或治疗伴有血管渗漏和/或血管炎症的疾病的方法，其包括施用特异性结合血管生成诱导因子促血管生成素-2（Ang2）的抗Ang2抗体或其抗原结合片段， 并与Tie2受体和Ang2形成复合物。
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公开(公告)号：US11174309B2
公开(公告)日：2021-11-16
申请号：US15823272
申请日：2017-11-27
Applicant: Samsung Electronics Co., Ltd
Inventor： Kyung Eun Kim , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
IPC: A61K39/395 , A61K39/00 , C07K16/22 , A61K38/18 , G01N33/74
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
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公开(公告)号：US09956244B2
公开(公告)日：2018-05-01
申请号：US14814278
申请日：2015-07-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Ji Min Lee , Bo Gyou Kim , Seung Ja Oh , Kyung Ah Kim , Saet Byoul Lee , Jae Woong Hwang
IPC: G01N33/50 , G01N33/574 , A61K31/713 , C07K16/28 , A61K39/395 , A61K45/06 , C07K16/30
CPC classification number: A61K31/713 , A61K39/39533 , A61K39/39558 , A61K45/06 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/54 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G01N33/57484 , G01N2800/52 , A61K2300/00 , A61K31/573
Abstract: A biomarker Hsp90 for predicting an efficacy of a c-Met inhibitor, selecting a subject for application of a c-Met inhibitor, or monitoring an efficacy of a c-Met inhibitor, and a relevant method of using Hsp90.
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公开(公告)号：US09828422B2
公开(公告)日：2017-11-28
申请号：US14446228
申请日：2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung Eun Kim , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
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10.发明申请POLYPEPTIDE, ANTI-VEGF ANTIBODY, AND ANTI-C-MET/ANTI-VEGF BISPECIFIC ANTIBODIES COMPRISING THE SAME 审中-公开多肽，抗VEGF抗体和包含该抗体的抗-C-MET /抗-VEGF-BISPECIFIC抗体公开(公告)号：US20160090427A1
公开(公告)日：2016-03-31
申请号：US14869636
申请日：2015-09-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun Lee , Soo Yeon Jung , Bo Gyou Kim , Seung Ja Oh , Ji Min Lee
CPC classification number: C07K16/22 , A61K39/3955 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/74
Abstract: A polypeptide, an anti-VEGF antibody and an anti-c-Met/anti-VEGF bispecific antibody, which includes the polypeptide, a pharmaceutical composition including the antibody, and a method of treating cancer using the antibody.
Abstract translation: 包括该多肽的多肽，抗VEGF抗体和抗c-Met /抗VEGF双特异性抗体，包含该抗体的药物组合物和使用该抗体治疗癌症的方法。
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