公开(公告)号：US20050176724A1

公开(公告)日：2005-08-11

申请号：US10504114

申请日：2003-02-17

申请人： Sean Flynn ,  Paul Smith ,  Kevin Thewlis ,  Simon Ward

发明人： Sean Flynn ,  Paul Smith ,  Kevin Thewlis ,  Simon Ward

IPC分类号： A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D215/20 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D43/02

CPC分类号： C07D401/12 ,  C07D215/20 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A is optionally substituted phenyl, indolyl, quinolinyl, quinazolinyl, indazolyl or isoquinolinyl; X is carbon, Y is CH and ═ is a double bond; or X is CH, Y is CH2 or oxygen and ═ is a single bond; or X is nitrogen, Y is CH2 and ═ is a single bond; R1 is halogen, cyano, nitro, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy, C3-7heterocyclylC1-6alkyl, C3-7heterocyclyl C1-6alkoxy; a is 0, 1, 2, 3 or 4; R2 is either: halogen, —CN, an optionally substituted C3-7cycloalkyl, an optionally substituted aryl or an optionally substituted C-linked 3-7 membered heterocyclic group; or a group -(Z)b-B wherein: (i) Z is oxygen, CH2, C═O, SO2 or C═N—OR3 wherein R3 is hydrogen or C1-6alkyl; b is 1, 2, or 3; and B is hydrogen, C1-6alkyl, C3-7cycloalkyl, C1-6alkoxy or NR4R5 wherein R4 and R5 are independently hydrogen, C1-6alkyl, C3-7cycloalkyl, C1-6alkanoyl, fluoroC1-6alkanoyl, C1-6alkylsulfonyl, fluoroC1-6alkylsulfonyl, carbamoyl or C1-6alkylcarbamoyl, or R4 and R5, together with the nitrogen atom to which they are attached, form part of an optionally substituted 3 to 7 membered heterocyclic group; or (ii) Z is oxygen, CH or CH2, b is 1, and B forms the rest of an aryl or a C3-7heterocyclic group fused to the phenyl ring; excluding 1-[2-[2-(phenylmethyl)phenoxy]ethyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-piperazine and pharmaceutically acceptable salts thereof, and N-[4-[2-[4-[(3,4-dimethoxyphenyl)methyl]-1-piperazinyl]ethoxy]phenyl]-ethanesulfonamide and pharmaceutically acceptable salts thereof. Methods of preparing the compounds and uses of the compounds in therapy, in particular for CNS disorders such as depression and anxiety, are also disclosed.

公开(公告)号：US20050107410A1

公开(公告)日：2005-05-19

申请号：US10503833

申请日：2003-02-17

申请人： Paul Smith ,  Kevin Thewlis ,  Antonio Vong ,  Simon Ward

发明人： Paul Smith ,  Kevin Thewlis ,  Antonio Vong ,  Simon Ward

IPC分类号： A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/551 ,  A61P1/04 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P15/00 ,  A61P15/06 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/32 ,  A61P25/36 ,  A61P29/00 ,  A61P43/00 ,  C07D215/20 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D41/02 ,  C07D43/02

CPC分类号： C07D401/12 ,  C07D215/20 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CH2 or oxygen and is a single bond; or X is nitrogen, Y is CH2 and is a single bond; is halogen, hydroxy, cyano, C1-6alkyl, haloC1-6alkyl or C1-6alkoxy; a is 0, 1, 2, 3 or 4; R2 and R3, together with the nitrogen atom to which they are attached, form a nitro group or an optionally substituted 3 to 7 membered heterocyclic group, or R2 and R3 are independently hydrogen, aroyl, C1-6alkyl, C1-6alkanoyl, fluoroC1-6alkanoyl, C1-6alkylsulfonyl, fluoroC1-6alkylsulfonyl, carbamoyl, C1-6alkylcarbamoyl, arylC1-6alkyl or a group CO(CH2)bNR4R5 wherein b is 1, 2, 3 or 4; and R4 and R5 are independently hydrogen or C1-6alkyl, or R4 and R5, together with the nitrogen atom to they are attached, form part of an optionally substituted 3 to 7 membered heterocyclic group. Methods of preparing the compounds and uses of the compounds in therapy, in particular for CNS disorders such as depression and anxiety, are also disclosed.

摘要翻译： 公开了式（I）化合物及其药学上可接受的盐：其中：A为任选取代的苯基，萘基，吲哚基，喹啉基，喹唑啉基，吲唑基，异喹啉基或苯并呋喃基; X是碳，Y是CH并且是双键; 或X是CH，Y是CH 2或氧并且是单键; 或X是氮，Y是CH 2，并且是单键; 是卤素，羟基，氰基，C 1-6烷基，卤代C 1-6烷基或C 1-6烷氧基; a是0，1，2，3或4; R2和R3与它们所连接的氮原子一起形成硝基或任选取代的3至7元杂环基，或R 2和R 3独立地是氢，芳酰基，C 1-6 烷基，C 1-6烷酰基，氟代C 1-6烷酰基，C 1-6烷基磺酰基，氟代C 1-6烷基， 烷基磺酰基，氨基甲酰基，C 1-6烷基氨基甲酰基，芳基C 1-6 - 烷基或基团CO（CH 2）2 bRR 4 R 5，其中b 是1，2，3或4; 并且R 4和R 5独立地为氢或C 1-6烷基，或者R 4和R 5与它们连接的氮原子一起形成任选取代的3至7元杂环基的一部分。 还公开了制备化合物的方法和化合物在治疗中的用途，特别是CNS障碍如抑郁和焦虑。

公开(公告)号：US20050085458A1

公开(公告)日：2005-04-21

申请号：US10504109

申请日：2003-02-17

申请人： Frank Harrington ,  Paul Smith ,  Simon Ward

发明人： Frank Harrington ,  Paul Smith ,  Simon Ward

IPC分类号： A61K31/4709 ,  A61K31/496 ,  A61K31/498 ,  A61K31/538 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/02 ,  A61K31/58

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; b is 1, 2 or 3 and c is 1, 2 or 3, wherein b+c is 2, 3, 4 or 5; X is carbon, Y is CH, is a double bond and e is 0; or X is carbon, Y is CH2 or oxygen, is a single bond and e is 1; or X is nitrogen, Y is CH2, is a single bond and e is 0; R1 is hydrogen, cyano, halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, NHCOCH3 or OCONR5R6, wherein R5 and R6 are independently hydrogen or C1-6alkyl; R2 is halogen, cyano or C1-6alkoxy; d is 0, 1, 2 or 3; R3 is hydrogen, C1-6alkyl, C1-6alkanoyl, fluoroC1-6alkanoyl, C1-6alkylsulfonyl, fluoroC1-6alkylsulfonyl, carbamoyl, C1-6alkylcarbamoyl or arylC1-6alkyl; and R4, together with the nitrogen atom to which it is attached, forms an optionally substituted 5 to 7 membered heterocyclic group fused to the benzene ring, provided that when a compound of formula (I) has the following structure: wherein A, b, c, R1, e, X, Y, R2 and d are as defined above and R3 is hydrogen, C1-6alkyl or arylC1-6alkyl, then (i) X is carbon, Y is CH and is a double bond; or (ii) b and c are both 1; or (iii) the carbon atom adjacent to the oxo-substituted carbon atom in the morpholinyl ring, marked “*”, is substituted. Methods of preparing the compounds and uses of the compounds in therapy, in particular for a CNS disorder such as depression or anxiety, are also disclosed.

公开(公告)号：US20180047429A1

公开(公告)日：2018-02-15

申请号：US15673641

申请日：2017-08-10

申请人： Paul Smith

发明人： Paul Smith

IPC分类号： G11B27/34 ,  G11B27/031 ,  H04N21/845 ,  H04N21/472 ,  H04N21/84

摘要： A user can quickly and efficiently create, edit, search, playback and share bookmarks in one or more videos that are pre-recorded or being recorded or streaming live. The bookmark includes reference to a portion of the video for an amount of time. The bookmark portions may not include a specified end time. The bookmark may include the source of the video, a start time of the bookmarked portion of the video stream or file, a length of the referenced video portion, and content such as text, emoticons, or other content received from a user that creates, edits, or manages the bookmark. The bookmarks may be grouped together into a set of bookmarks, thereby forming an edit of the original streaming or pre-recorded videos when played sequentially, wherein the edit includes a set of bookmarked video portions (bookmarked videos) taken from one or more particular live streaming or pre-recorded videos.

公开(公告)号：US09743977B2

公开(公告)日：2017-08-29

申请号：US13747047

申请日：2013-01-22

申请人： Paul Smith ,  Eric K. Litscher ,  Samuel Raybin ,  John B. Golden ,  Michael E. Zupkofska

发明人： Paul Smith ,  Eric K. Litscher ,  Samuel Raybin ,  John B. Golden ,  Michael E. Zupkofska

IPC分类号： A61B17/00 ,  A61B17/28 ,  A61B18/14 ,  A61B17/32 ,  A61B17/34 ,  A61B34/00 ,  A61B17/29 ,  A61B18/00

CPC分类号： A61B18/1477 ,  A61B17/320016 ,  A61B17/3478 ,  A61B18/1492 ,  A61B34/71 ,  A61B2017/00269 ,  A61B2017/2927 ,  A61B2018/0091 ,  A61B2018/1425 ,  A61B2217/007 ,  A61B2218/002

摘要： Embodiments of the disclosure are directed to a medical device. The medical device may include a shaft having a proximal end and a distal end. A positioning mechanism may be disposed adjacent the distal end of the shaft. The positioning mechanism may include an outer member and an inner member coupled to an end-effector. The outer member may be pivotably attached to the distal end of the shaft and the inner member may be pivotably attached to the outer member.

公开(公告)号：US09645091B2

公开(公告)日：2017-05-09

申请号：US13165769

申请日：2011-06-21

申请人： Paul D. Slowey ,  James Wickstead ,  Keith Seritella ,  Brian Forbes ,  John Ennis ,  Richard Herrig ,  Jason Giddings ,  Paul Smith

发明人： Paul D. Slowey ,  James Wickstead ,  Keith Seritella ,  Brian Forbes ,  John Ennis ,  Richard Herrig ,  Jason Giddings ,  Paul Smith

IPC分类号： G01N21/75 ,  G01N21/84

CPC分类号： G01N21/8483 ,  G01N2201/0221 ,  Y10T436/11

摘要： A portable, hand-held electro-optical reader and specimen sample collector is provided, including an absorbent pad, one or more test strips contained in the collector handle to provide observable results through a window, the handle insertable into the reader for immediate recording and analysis. The system includes means to automatically provide subject and test specific data with the test results and retain samples for later verification analysis.

公开(公告)号：US09561021B2

公开(公告)日：2017-02-07

申请号：US13094736

申请日：2011-04-26

申请人： Jon T. McIntyre ,  Barry Weitzner ,  Paul DiCarlo ,  Paul Smith

发明人： Jon T. McIntyre ,  Barry Weitzner ,  Paul DiCarlo ,  Paul Smith

IPC分类号： A61B17/00 ,  A61B17/42 ,  A61B17/29 ,  A61B17/32 ,  A61B18/14

CPC分类号： A61B17/00234 ,  A61B17/29 ,  A61B17/320016 ,  A61B17/42 ,  A61B18/1492 ,  A61B2017/00278 ,  A61B2017/003 ,  A61B2017/00477 ,  A61B2017/00876 ,  A61B2018/143 ,  A61B2018/1432

摘要： Embodiments include a method of performing a medical procedure in a patient. The method includes inserting a first working instrument and a second working instrument through an opening in the patient, creating an incision in body tissue inside the patient using at least one of the first and second working instruments, and advancing the second working instrument through the incision to position the second working instrument at a work site inside the patient. The method also includes positioning the first working instrument at the work site without advancing the first working instrument through the incision and performing a procedure at the work site inside the patient using the first and second working instruments.

摘要翻译： 实施例包括在患者体内执行医疗程序的方法。 该方法包括通过患者的开口插入第一工作器械和第二工作器械，使用第一和第二工作器械中的至少一个在身体组织内产生切口，并通过切口推进第二工作器械 将第二工作仪器定位在患者体内的工作现场。 该方法还包括将第一工作仪器定位在工作现场，而不通过切口推进第一工作仪器，并使用第一和第二工作仪器在病人内的工作现场执行过程。

公开(公告)号：US09109742B2

公开(公告)日：2015-08-18

申请号：US13061910

申请日：2009-08-31

申请人： Paul Smith

发明人： Paul Smith

IPC分类号： H04N5/64 ,  F16M13/02 ,  F16M11/10

CPC分类号： F16M13/02 ,  F16M11/10 ,  F16M2200/061

摘要： A low-profile mount for a flat panel electronic display that is selectively shiftable between a wall-confronting position wherein the back of the flat panel electronic display is disposed parallel and proximate to the wall surface and a tilt position wherein the top of the display is tilted away from the wall surface. The mount is configured so that points spaced apart forwardly from display receiving surfaces of the mount are shifted along a substantially horizontal axis as the mount is shifted between the wall confronting position and the tilt position. Advantageously, the display can be attached to the mount so that the points are horizontally registered with a center of gravity of the display such that the display is self-balancing at any point along the travel between the wall confronting position and the tilt position.

摘要翻译： 一种用于平板电子显示器的薄型安装件，其可在壁对面位置之间选择性地移动，其中平板电子显示器的背面平行并靠近壁表面，以及倾斜位置，其中显示器的顶部为 倾斜远离墙面。 安装件被构造成使得当安装件在壁面相对位置和倾斜位置之间移动时，使得从安装件的显示器接收表面向前间隔开的点沿着基本上水平的轴线移动。 有利地，显示器可以附接到安装件，使得点与显示器的重心水平地对准，使得显示器在沿着面向对面的位置和倾斜位置之间的行进的任何点处是自平衡的。

公开(公告)号：US08822515B2

公开(公告)日：2014-09-02

申请号：US13502244

申请日：2010-10-18

申请人： Paul Smith ,  Dawn Ward

发明人： Paul Smith ,  Dawn Ward

IPC分类号： A61K31/42 ,  C07D263/57 ,  C07D413/04

CPC分类号： C07D413/04 ,  A61K31/42 ,  C07D263/57

摘要： This invention relates to benzoxazole compounds, compositions and devices for delivering them, processes for manufacturing them, and methods of using them in the treatment of Hepatitis C Virus.

摘要翻译： 本发明涉及苯并恶唑化合物，用于递送它们的组合物和装置，其制备方法，以及使用它们在丙型肝炎病毒治疗中的方法。

公开(公告)号：US20130211403A1

公开(公告)日：2013-08-15

申请号：US13763220

申请日：2013-02-08

申请人： Naroun Suon ,  Ra Nam ,  Samuel Raybin ,  Paul Smith ,  Jonathan Root

发明人： Naroun Suon ,  Ra Nam ,  Samuel Raybin ,  Paul Smith ,  Jonathan Root

IPC分类号： A61B18/04

CPC分类号： A61B18/04 ,  A61B17/32 ,  A61B18/1485 ,  A61B18/149 ,  A61B18/1492 ,  A61B2017/00269 ,  A61B2018/00184 ,  A61B2018/1407 ,  A61B2018/141 ,  A61B2018/144 ,  A61B2018/1475

摘要： A medical device and related method of use for cutting tissue is described. The device includes an elongate tubular member having a proximal end, a distal end, and first and second lumens extending between the proximal and distal ends. The device further includes a first elongate arm having a third lumen extending distally from the first lumen and a second elongate arm having a fourth lumen extending distally from the second lumen. A cutting element extends from the third lumen of the first arm to the fourth lumen of the second arm, such that the cutting element is slidably disposed in at least one of the third and fourth lumens.

摘要翻译： 描述了用于切割组织的医疗装置和相关的使用方法。 该装置包括具有近端，远端以及在近端和远端之间延伸的第一和第二腔的细长管状构件。 该装置还包括具有从第一内腔向远侧延伸的第三腔的第一细长臂和具有从第二腔向远侧延伸的第四腔的第二细长臂。 切割元件从第一臂的第三腔延伸到第二臂的第四腔，使得切割元件可滑动地设置在第三和第四腔中的至少一个腔中。