公开(公告)号：US4844911A

公开(公告)日：1989-07-04

申请号：US108201

申请日：1987-10-14

申请人： Shigeya Kakimoto ,  Yasuhiro Sumino ,  Hideaki Yamada ,  Satoshi Imayasu ,  Eiji Ichikawa ,  Tetsuyoshi Suizu

发明人： Shigeya Kakimoto ,  Yasuhiro Sumino ,  Hideaki Yamada ,  Satoshi Imayasu ,  Eiji Ichikawa ,  Tetsuyoshi Suizu

IPC分类号： C12H1/00 ,  C12H1/15 ,  C12N9/80

CPC分类号： C12R1/225 ,  C12H1/003 ,  C12N9/80 ,  C12R1/46

摘要： Alcoholic liquors containing carbamide are treated with the urease which has the optimal pH for the activity in an acid region, especially in the region of pH2 to 5. By such treatment, the carbamide can be completely decomposed and removed from the alcoholic liquors in a much smaller amount of urease and in a short time as compared with a conventional treatment according to a urease having the optimal pH in the neutral to alkaline region. This method is more advantageous from the viewpoint of practical use and the quality of the thus obtained alcoholic liquors are superior to that obtained by the conventional treatment.

公开(公告)号：US5093255A

公开(公告)日：1992-03-03

申请号：US217355

申请日：1988-07-11

申请人： Shigeya Kakimoto ,  Yasuhiro Sumino ,  Takashi Suzuki

发明人： Shigeya Kakimoto ,  Yasuhiro Sumino ,  Takashi Suzuki

IPC分类号： C12N9/80

CPC分类号： C12R1/225 ,  C12N9/80 ,  C12R1/46 ,  Y10S435/803 ,  Y10S435/814 ,  Y10S435/853 ,  Y10S435/885

摘要： A novel urease having an optimal pH for activity in the acidic region is produced by a microorganism belonging to the genus Lactobacillus or Streptococcus. The urease is superior to the conventional urease in pH stability, temperature stability and alcohol stability.

公开(公告)号：US5000966A

公开(公告)日：1991-03-19

申请号：US282044

申请日：1988-12-09

申请人： Yasuhiro Sumino ,  Shigeya Kakimoto ,  Shun-ichi Akiyama

发明人： Yasuhiro Sumino ,  Shigeya Kakimoto ,  Shun-ichi Akiyama

IPC分类号： C12N9/78 ,  C12H1/00 ,  C12H1/14 ,  C12H1/15

CPC分类号： C12H1/003 ,  Y10S435/822 ,  Y10S435/824 ,  Y10S435/829 ,  Y10S435/83 ,  Y10S435/85 ,  Y10S435/852 ,  Y10S435/911 ,  Y10S435/921

摘要： Ethyl carbamate in an alcoholic liquor is decomposed by contacting the alcoholic liquor with a culture broth or processed matter thereof obtained from a microorganism which belongs to the genus Gluconobacter, Flavobacterium, Arthrobacter, Achromobacter, Alcaligenes, Pseudomonas, Klebsiella, Rhodotorula, Rhodosporidium, Trichosporon or Candida, and is capable of decomposing ethyl carbamate. The alcoholic liquor is improved in quality, and has a low ethyl carbamate content.

公开(公告)号：US20090169610A1

公开(公告)日：2009-07-02

申请号：US12223517

申请日：2007-02-02

申请人： Noboru Yamazaki ,  Sei Yoshida ,  Masuo Yamaoka ,  Akira Hori ,  Shigeya Kakimoto ,  Shuichi Furuya

发明人： Noboru Yamazaki ,  Sei Yoshida ,  Masuo Yamaoka ,  Akira Hori ,  Shigeya Kakimoto ,  Shuichi Furuya

IPC分类号： A61K9/127 ,  A61K39/395

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K31/282 ,  A61K31/337 ,  A61K31/513 ,  A61K31/537 ,  A61K31/573 ,  A61K31/7068 ,  A61K47/6911

摘要： The present invention provides cancer treatment preparations of excellent targetability. The sugar chain-modified liposomes of the present invention, which contain an aromatase inhibitor, anti-androgenic agent, lyase inhibitor, GnRH agonist, GnRH antagonist, anti-angiogenic agent, tyrosine kinase inhibitor, serine-threonine kinase inhibitor, antibody having an anticancer activity, ansamitocin, capecitabine, celmoleukin, docetaxel hydrate, gemcitabine hydrochloride, oxaliplatin, prednisolone, tegafur-uracil mixtures, zinostatin stimalamer or arsenic trioxide may be used as cancer treatment preparations having an excellent targetability.

摘要翻译： 本发明提供了具有优异目标性的癌症治疗制剂。 含有芳香酶抑制剂，抗雄激素剂，裂解酶抑制剂，GnRH激动剂，GnRH拮抗剂，抗血管生成剂，酪氨酸激酶抑制剂，丝氨酸 - 苏氨酸激酶抑制剂，抗癌剂的本发明糖链修饰脂质体 活性，安曲霉素，卡培他滨，纤维白蛋白，多西紫杉醇水合物，盐酸吉西他滨，奥沙利铂，泼尼松龙，替加氟 - 尿嘧啶混合物，维生素D抑制素或三氧化二砷可用作具有优异靶向性的癌症治疗制剂。

公开(公告)号：US20060183158A1

公开(公告)日：2006-08-17

申请号：US11353221

申请日：2006-02-10

申请人： Hideaki Tojo ,  Nozomi Katayama ,  Shigeya Kakimoto

发明人： Hideaki Tojo ,  Nozomi Katayama ,  Shigeya Kakimoto

IPC分类号： G01N33/53 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/47 ,  A61K38/00

摘要： A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

摘要翻译： 编码该蛋白质的蛋白质和DNA可用作诸如低血糖等疾病的预防剂/治疗剂。本发明的蛋白质也可用作筛选抑制本发明的蛋白质与IRAP结合的化合物的试剂 （胰岛素反应性氨基肽酶）或GLUT4（葡萄糖转运蛋白4）。 抑制本发明的蛋白质与IRAP或GLUT4结合的化合物可用作疾病例如高血糖症，糖尿病等的预防/治疗。

公开(公告)号：US07294475B2

公开(公告)日：2007-11-13

申请号：US11353221

申请日：2006-02-10

申请人： Hideaki Tojo ,  Nozomi Katayama ,  Shigeya Kakimoto

发明人： Hideaki Tojo ,  Nozomi Katayama ,  Shigeya Kakimoto

IPC分类号： G01N33/53 ,  C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

摘要翻译： 编码该蛋白质的蛋白质和DNA可用作诸如低血糖等疾病的预防剂/治疗剂。本发明的蛋白质也可用作筛选抑制本发明的蛋白质与IRAP结合的化合物的试剂 （胰岛素反应性氨基肽酶）或GLUT4（葡萄糖转运蛋白4）。 抑制本发明的蛋白质与IRAP或GLUT4结合的化合物可用作疾病例如高血糖症，糖尿病等的预防/治疗。

公开(公告)号：US07064106B2

公开(公告)日：2006-06-20

申请号：US10168067

申请日：2000-12-19

申请人： Hideaki Tojo ,  Nozomi Katayama ,  Shigeya Kakimoto

发明人： Hideaki Tojo ,  Nozomi Katayama ,  Shigeya Kakimoto

IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K14/705 ,  C07K16/28 ,  G01N33/567

CPC分类号： C07K14/47 ,  A61K38/00

摘要： A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

摘要翻译： 编码该蛋白质的蛋白质和DNA可用作诸如低血糖等疾病的预防剂/治疗剂。本发明的蛋白质也可用作筛选抑制本发明的蛋白质与IRAP结合的化合物的试剂 （胰岛素反应性氨基肽酶）或GLUT4（葡萄糖转运蛋白4）。 抑制本发明的蛋白质与IRAP或GLUT4结合的化合物可用作疾病例如高血糖症，糖尿病等的预防/治疗。