利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

142 records (took 0.016 seconds)

    Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
    2.
    发明授权
    Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion 失效
    制备玉米黄质的纯3R-3'R立体异构体进行人体摄取的方法

    公开(公告)号：US5854015A

    公开(公告)日：1998-12-29

    申请号：US551166

    申请日：1995-10-31

    Applicant: Kevin M. Garnett ,  Dennis L. Gierhart ,  Luis H. Guerra-Santos

    Inventor： Kevin M. Garnett ,  Dennis L. Gierhart ,  Luis H. Guerra-Santos

    IPC: A61K31/047 ,  C12P23/00

    CPC classification number: A61K31/047 ,  Y10S435/85

    Abstract: A method is disclosed for making the 3R-3'R stereoisomer of zeaxanthin as a sole detectable or heavily dominant (more than about 90%) stereoisomer, for human ingestion. Zeaxanthin, a yellowish pigment which is naturally present in macular cells in the center of the human retina, absorbs blue and near-ultraviolet light radiation, thereby protecting the retinal cells against phototoxic damage. Zeaxanthin preparations which contain only the desired R--R isomer can be produced by a strain of Flavobacterium multivorum cells (ATCC accession number 55238). These cells (and other cells transformed with their zeaxanthin-producing genes) do not create any detectable quantities of the undesired S--S or S-R isomers of zeaxanthin, and they do not synthesize significant quantities of other carotenoids which might compete against zeaxanthin for alimentary uptake after oral ingestion. After synthesis using cell fermentation, the zeaxanthin can be concentrated to about 5-20% by simple and inexpensive steps such as solvent extraction, and can be purified to much higher levels by other methods if desired. The isomerically pure preparations can be taken orally, either as a therapeutic drug by patients suffering from macular degeneration, or as a nutritional supplement by anyone who wants to reduce his or her risk of suffering from age-related macular degeneration, which is widespread among people over the age of about 50 or 60.

    Abstract translation: 公开了一种用于使玉米黄质的3R-3'R立体异构体作为唯一可检测或重占优势（超过约90％）立体异构体的方法，用于人体摄取。 天然存在于人类视网膜中心的黄斑细胞中的淡黄色素的玉米黄质吸收蓝色和近紫外光的辐射，从而保护视网膜细胞免受光毒性损伤。 仅含有所需R-R异构体的玉米黄质制剂可以通过多变黄杆菌细菌菌株（ATCC登录号55238）产生。 这些细胞（和其产生的玉米黄质的基因转化的其他细胞）不产生任何可检测量的玉米黄质的不希望的SS或SR异构体，并且它们不合成显着量的其它类胡萝卜素，其可以与口服玉米黄质竞争消化吸收 摄入 在使用细胞发酵合成后，可以通过简单且便宜的步骤如溶剂萃取将玉米黄质浓缩至约5-20％，并且如果需要可以通过其它方法纯化至更高的水平。 异构纯的制剂可以口服给药，作为患有黄斑变性的患者的治疗药物，或作为营养补充剂，任何人谁希望降低患有年龄相关性黄斑变性的风险，这在人群中很普遍 年龄约50或60岁。

    Microbiological methods
    8.
    发明授权
    Microbiological methods 失效
    微生物方法

    公开(公告)号：US4138291A

    公开(公告)日：1979-02-06

    申请号：US822756

    申请日：1977-08-08

    Applicant: Robert M. Lafferty

    Inventor： Robert M. Lafferty

    IPC: C12N1/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/01 ,  C12P7/62 ,  C12D1/02

    CPC classification number: C12P7/625 ,  Y10S435/85

    Abstract: The invention relates to a method of obtaining selected bacterial strains which can convert an assimilable carbon source selected from carbohydrates, methanol, ethanol, glycerin, carbon dioxide and spent lyes from caprolactam synthesis into poly-(D-3-hydroxybutyric acid), selected bacterial strains obtained thereby and their use in producing poly-(D-3-hydroxybutyric acid).

    Abstract translation: 本发明涉及一种获得选择的细菌菌株的方法，其可以将选自碳水化合物，甲醇，乙醇，甘油，二氧化碳和废碱的可同化碳源从己内酰胺合成转化成聚 - （D-3-羟基丁酸），选择的细菌 由此获得的菌株及其在制备聚（D-3-羟基丁酸）中的用途。

    Production of zeaxanthin
    10.
    发明授权
    Production of zeaxanthin 失效
    玉米黄质的生产

    公开(公告)号：US3951743A

    公开(公告)日：1976-04-20

    申请号：US489725

    申请日：1974-07-18

    Applicant: David Shepherd ,  Jaroslav Dasek ,  Mariette Suzanne Catherine Carels

    Inventor： David Shepherd ,  Jaroslav Dasek ,  Mariette Suzanne Catherine Carels

    IPC: A23K1/00 ,  C12P23/00 ,  C12R1/20 ,  C12D13/02

    CPC classification number: C12P23/00 ,  Y10S435/85

    Abstract: A process for the preparation of zeaxanthin which comprises culturing a microorganism of the genus Flavobacter producing this pigment in a nutrient medium containing at least one carbohydrate as assimilable carbon source, at least one source of assimilable amino nitrogen containing free amino acids, mineral salts, oligoelements and vitamins, the composition of the medium being modified by adding pyridoxine to it, and continuing culturing until a substantial quantity of intracellular zeaxanthin has been obtained.

    Abstract translation: 一种玉米黄质的制备方法，其包括在含有至少一种碳水化合物作为可同化碳源的至少一种含可游离氨基酸的可吸收的氨基酸源，无机盐，寡糖类的培养基中培养产生该颜料的黄杆菌属的微生物 和维生素，通过向其中加入吡哆醇来修饰培养基的组成，并继续培养直到获得了大量的细胞内玉米黄质。

Patent Agency Ranking