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公开(公告)号：US07307063B2
公开(公告)日：2007-12-11
申请号：US10640755
申请日：2003-08-13
申请人： Shubh Sharma , Annette Shadiack , Yi-Qun Shi , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Annette Shadiack , Yi-Qun Shi , Wei Yang , Hui-Zhi Cai
IPC分类号： C07K5/10
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1024 , C07K14/575 , C07K14/68
摘要： Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The metallopeptides are conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion. Also provided are metallopeptides that are antagonists for at least one of melanocortin-3 or melanocortin-4 receptors.
摘要翻译： 金属肽被用于治疗哺乳动物的性功能障碍。 金属肽是黑皮质素-3或黑皮质素-4受体中的至少一种的激动剂。 金属肽在与金属离子的金属离子结合部分的络合作用下被构象地固定。 还提供了作为黑皮质素-3或黑皮质素-4受体中的至少一种的拮抗剂的金属肽。
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公开(公告)号：US20070260040A1
公开(公告)日：2007-11-08
申请号：US11694181
申请日：2007-03-30
申请人： Shubh Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
IPC分类号： C07D403/02 , C07K1/02
CPC分类号： C07K14/58 , C07D403/04 , C07K7/16
摘要： Ring-constrained amino acid surrogates of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification, methods for synthesizing ring-constrained amino acid surrogates of formula I, methods of use of ring-constrained amino acid surrogates of formula I, including use in linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I and linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I.
摘要翻译： 式I的环受限氨基酸替代物：其中R 1，R 2，R 3，R 4， R 5，R 6a，R 6b，R 7和Y如说明书中所定义， 用于合成式I的环受限氨基酸替代物的方法，使用式I的环受限氨基酸替代物的方法，包括用于线性或环状化合物的方法，所述线性或环状化合物包括多个氨基酸残基和一个或多个环受约束的氨基 式I的酸替代物和包括多个氨基酸残基和一个或多个式I的环受限氨基酸替代物的线性或环状化合物。
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公开(公告)号：US20050181447A1
公开(公告)日：2005-08-18
申请号：US10150979
申请日：2002-05-17
申请人： Shubh Sharma , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Wei Yang , Hui-Zhi Cai
IPC分类号： A61K51/04 , C07K1/04 , C07K5/10 , C07K5/103 , C07K5/107 , A61K38/16 , C07H21/04 , C07K14/00 , G01N33/53
CPC分类号： C07K5/1027 , A61K51/0478 , C07K1/047 , C07K5/1008 , C07K5/1016
摘要： Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one or more opioid receptors on complexation of a metal ion-binding portion thereof with a metal ion.
摘要翻译： 提供了对阿片类受体特异性的金属肽和金属肽组合文库，用于生物，药物和相关应用。 金属肽和组合文库由肽，肽模拟物和肽样构建体制成，其中肽，拟肽或构建体在一种或多种阿片受体特异性的生物活性构型中被构象地固定在金属离子结合部分的络合物上 与金属离子。
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公开(公告)号：US20070265206A1
公开(公告)日：2007-11-15
申请号：US11694260
申请日：2007-03-30
申请人： Shubh Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
CPC分类号： C07K14/58
摘要： Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
摘要翻译： 具有结合利尿钠肽受体并包含多个氨基酸残基的N末端和C末端的至少一个式I的氨基酸替代物的环状构建体：其中R，R'，Q，Y，W， Z，J，x和n如说明书中所定义，以及任选的至少一个假体基团，包括这种环状构建体的药物组合物，以及治疗充血性心力衰竭或其它病症的方法，综合征或疾病，其诱导抗高血压 ，心血管，肾脏或内分泌效应。
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公开(公告)号：US20060240481A1
公开(公告)日：2006-10-26
申请号：US11419557
申请日：2006-05-22
申请人： Shubh Sharma , Yiqun Shi , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Yiqun Shi , Wei Yang , Hui-Zhi Cai
CPC分类号： C07K5/1016 , A61K38/00 , A61K51/086 , A61K51/088 , C07K5/1008 , C07K5/1024 , C07K14/665
摘要： Melanocortin receptor-specific peptide combinatorial libraries for forming metallopeptides and metallopeptide combinatorial libraries are provided for use in biological, pharmaceutical and related applications. The combinatorial libraries are constructed of peptides constructed from naturally occurring amino acids, stereoisomers and modifications of such amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically modified amino acids, or constructs or structures designed to mimic amino acids, in which the peptides are conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.
摘要翻译： 提供用于形成金属肽和金属肽组合文库的黑皮质素受体特异性肽组合文库，用于生物，药物和相关应用。 组合文库由由天然存在的氨基酸构成的肽，这些氨基酸的立体异构体和修饰，非蛋白质氨基酸，翻译后修饰的氨基酸，酶修饰的氨基酸或被设计为模拟氨基酸的构建体或结构构成， 其中肽与金属离子结合部分与金属离子的络合被构象地固定。
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公开(公告)号：US20060083685A1
公开(公告)日：2006-04-20
申请号：US11291389
申请日：2005-12-01
申请人： Shubh Sharma , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Wei Yang , Hui-Zhi Cai
CPC分类号： C07K5/1027 , A61K51/0478 , C07K1/047 , C07K5/1008 , C07K5/1016
摘要： Metallopeptides and metallopeptide combinatorial libraries specific for opioid receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one or more opioid receptors on complexation of a metal ion-binding portion thereof with a metal ion.
摘要翻译： 提供了特异于阿片受体的金属肽和金属肽组合文库，用于生物，药物和相关应用。 金属肽和组合文库由肽，肽模拟物和肽样构建体制成，其中肽，拟肽或构建体在一种或多种阿片受体特异性的生物活性构型中被构象地固定在金属离子结合部分的络合物上 与金属离子。
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公开(公告)号：US08580747B2
公开(公告)日：2013-11-12
申请号：US12622055
申请日：2009-11-19
申请人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
CPC分类号： C07K14/58
摘要： Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
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公开(公告)号：US20070232546A1
公开(公告)日：2007-10-04
申请号：US11694358
申请日：2007-03-30
申请人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
CPC分类号： C07D241/08 , A61K38/00 , A61K47/60 , C07K14/58
摘要： Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group covalently bound to a reactive group of at least one of the amino acid residues or surrogates, pharmaceutical compositions including such linear constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
摘要翻译： 具有与利尿钠肽受体结合的N末端和C末端并且包括多个氨基酸残基和至少一个式I的氨基酸替代物的线性构建体：其中R，R'，Q，Y，W， Z，J，x和n如说明书中所定义，以及任选地至少一个与至少一个氨基酸残基或替代物的反应性基团共价结合的假基团，包括这种线型构建体的药物组合物，以及治疗方法 充血性心力衰竭或其它需要诱导抗高血压，心血管，肾或内分泌作用的综合征或疾病。
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公开(公告)号：US07622440B2
公开(公告)日：2009-11-24
申请号：US11694260
申请日：2007-03-30
申请人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
CPC分类号： C07K14/58
摘要： Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
摘要翻译： 具有结合利尿钠肽受体并包含多个氨基酸残基的N末端和C末端的至少一个式I的氨基酸替代物的环状构建体：其中R，R'，Q，Y，W， Z，J，x和n如说明书中所定义，以及任选的至少一个假体基团，包括这种环状构建体的药物组合物，以及治疗充血性心力衰竭或其它病症的方法，综合征或疾病，其诱导抗高血压 ，心血管，肾脏或内分泌效应。
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公开(公告)号：US07795221B2
公开(公告)日：2010-09-14
申请号：US11694358
申请日：2007-03-30
申请人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
IPC分类号： A61K38/10
CPC分类号： C07D241/08 , A61K38/00 , A61K47/60 , C07K14/58
摘要： Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group covalently bound to a reactive group of at least one of the amino acid residues or surrogates, pharmaceutical compositions including such linear constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
摘要翻译： 具有与利尿钠肽受体结合的N末端和C末端并且包括多个氨基酸残基和至少一个式I的氨基酸替代物的线性构建体：其中R，R'，Q，Y，W， Z，J，x和n如说明书中所定义，以及任选地至少一个与至少一个氨基酸残基或替代物的反应性基团共价结合的假基团，包括这种线型构建体的药物组合物，以及治疗方法 充血性心力衰竭或其它需要诱导抗高血压，心血管，肾或内分泌作用的综合征或疾病。
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