公开(公告)号：US20250011845A1

公开(公告)日：2025-01-09

申请号：US18707776

申请日：2022-11-04

Applicant: Solventum Intellectual Properties Company

Inventor： Annabelle Watts ,  Tonya D. Bonilla ,  Jerald K. Rasmussen ,  Joshua M. Fishman ,  Lindsay L. Traeger ,  Semra Colak Atan

IPC: C12Q1/6834 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N27/447

Abstract: A method of processing polynucleic acids is described comprising: providing a solid support comprising ligands with an amide group: exposing the solid support to polynucleic acid molecules in a buffer having a pH less than 5.5 to bind at least a portion of the polynucleic acid molecules to the ligands: c) exposing the solid support (e.g. particles) with bound polynucleic acid molecules to a buffer having a pH greater than 6 to release a portion of the bound polynucleic acid molecules from the ligands of the particles and to retain a portion of the polynucleic acid molecules bound to the solid support (e.g. particles); and utilizing the solid support with retained bound polynucleic acid molecules or suspension thereof.

公开(公告)号：US12295369B2

公开(公告)日：2025-05-13

申请号：US17597488

申请日：2020-07-23

Applicant: Solventum Intellectual Properties Company

Inventor： Andrew W. Vail ,  Jerald K. Rasmussen ,  Robert A. Schmitz

IPC: A01N47/44 ,  A01N25/10 ,  A01N25/34

Abstract: An article, and method of use, wherein the article includes: a substrate; a cationic coating bound to the substrate, wherein the cationic coating includes a guanidinyl-containing polymer that is crosslinked on the substrate; wherein the guanidinyl-containing polymer is of the following Formula (I), wherein: R3 is a H, C1-C12(hetero)alkyl, C5-C12(hetero)aryl, or Polymer; each R4 is independently H, C1-C12(hetero)alkyl, or C5-C12(hetero)aryl; each R5 is H, C1-C12(hetero)alkyl, C5-C12(hetero)aryl, or N(R4)2; Polymer is a residue of an aminopolymer chain; m is 1 or 2; and x is an integer of at least 1; and wherein the guanidinyl-containing polymer is crosslinked with an amine-reactive polyepoxy compound having pendant —OH groups.

公开(公告)号：US12064730B2

公开(公告)日：2024-08-20

申请号：US15733205

申请日：2018-12-14

Applicant: Solventum Intellectual Properties Company

Inventor： Jerald K. Rasmussen ,  Stephen B. Roscoe ,  Babu N. Gaddam ,  George W. Griesgraber ,  Daniel J. O'Neal ,  Eli P. Narveson

IPC: B01D67/00 ,  B01D69/02 ,  B01D69/10 ,  C08J7/18 ,  C12M1/00 ,  G01N33/543 ,  G01N33/545

CPC classification number: B01D67/0006 ,  B01D67/00931 ,  B01D69/02 ,  B01D69/105 ,  B01D69/1071 ,  C08J7/18 ,  C12M29/04 ,  G01N33/54393 ,  G01N33/545 ,  B01D2323/38 ,  C08J2377/02

Abstract: Articles with covalently attached thiocarbonylthio-containing groups are provided. More specifically, the articles include a solid polymeric substrate with a plurality of thiocarbonylthio-containing groups covalently attached directly to a carbon atom in a polymeric backbone of the solid polymeric substrate. Methods of making the articles with covalently attached thiocarbonylthio-containing are provided. Additionally, methods of using these articles to generate further articles with covalently attached polymeric chains are provided.