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    Fibronectin type III domain based scaffold compositions, methods and uses
    3.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US08293482B2

    公开(公告)日：2012-10-23

    申请号：US12704824

    申请日：2010-02-12

    Applicant: Steven Jacobs ,  Karyn O'Neil

    Inventor： Steven Jacobs ,  Karyn O'Neil

    IPC: C07K16/00 ,  G01N33/53

    CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

    Abstract translation: 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。

    Mobile vehicle sensor array
    6.
    发明授权
    Mobile vehicle sensor array 有权
    移动车载传感器阵列

    公开(公告)号：US07047132B2

    公开(公告)日：2006-05-16

    申请号：US10756635

    申请日：2004-01-12

    Applicant: Steven Jacobs

    Inventor： Steven Jacobs

    IPC: G01S15/04

    CPC classification number: G05D1/0242 ,  G05D1/024

    Abstract: An improved sensor array for a mobile vehicle. The vehicle includes a centerline parallel to a vehicle velocity vector. The sensor array comprises a first sensor mounted to the mobile vehicle at a maximum lateral distance from the centerline near a first side of mobile vehicle and a second sensor mounted to the mobile vehicle at a maximum lateral distance from the centerline near a second side of the vehicle opposite the first side. The first sensor transmits a forward pointing first beam and the second sensor transmits a forward pointing second beam, both beams for detecting an object in the path of the vehicle. A plurality of first oblique beams are pointed to intersect the first beam and a plurality of second oblique beams are pointed to intersect the second beam. The oblique beams, in conjunction with the first and second beams form zones of overlapping beam coverage for better localization of objects in the path of the vehicle.

    Abstract translation: 一种用于移动车辆的改进的传感器阵列。 车辆包括平行于车速矢量的中心线。 所述传感器阵列包括安装在所述移动车辆上的第一传感器，所述第一传感器在距离所述移动车辆的第一侧附近的所述中心线的最大横向距离处安装有第二传感器，以及安装到所述移动车辆的第二传感器， 车辆与第一侧相对。 第一传感器传输前向指向的第一光束，第二传感器传输前向指向的第二光束，两个光束用于检测车辆路径中的物体。 多个第一倾斜光束被指向与第一光束相交，并且多个第二倾斜光束指向与第二光束相交。 斜梁与第一和第二波束结合形成重叠波束覆盖的区域，以便更好地在车辆路径中定位物体。

    Apparatus for determining an area coverage rate
    7.
    发明授权
    Apparatus for determining an area coverage rate 失效
    用于确定区域覆盖率的装置

    公开(公告)号：US5038484A

    公开(公告)日：1991-08-13

    申请号：US379618

    申请日：1989-07-14

    Applicant: Quentin H. Rench ,  Steven Jacobs

    Inventor： Quentin H. Rench ,  Steven Jacobs

    IPC: A47L11/40 ,  E01C19/00 ,  E01H1/00 ,  G01B7/32

    CPC classification number: A47L11/4011 ,  A47L11/4061 ,  E01C19/004 ,  E01H1/00 ,  G01B7/32 ,  A47L2201/04

    Abstract: An apparatus for determining an area of a surface which is traversed and treated by an object during a unit of time is configured for use with a moveable object that has a first axis of a known length. The object is capable of movement along a second axis and the first and second axes define an angle between them which is other than 0.degree.. A signalling means includes a sensor which may be mounted in a motion-sensing relationship to the object for providing a motion signal when the object moves a distance along the second axis. The motion signal has a predetermined relationship to that distance. A timing means repetitively provides a plurality of timing signals, each sequential pair of which defines an interval of time of known duration. A computing means is coupled to the timing means and to the signalling means for receiving at least one sequential pair of timing signals and at least one motion signal. The computing means thereby initiate a display of the area of the surface which is traversed by the first axis per unit of time and therefore treated as the object moves along the second axis.

    Abstract translation: 一种用于确定在一个单位时间内由对象穿过和处理的表面的面积的装置被配置为与具有已知长度的第一轴的可移动对象一起使用。 该物体能够沿第二轴线移动，并且第一和第二轴线在它们之间形成一个不为0°的角度。 信号装置包括传感器，当传感器沿着第二轴线移动距离时，传感器可安装在与物体的运动感应关系中，以提供运动信号。 运动信号与该距离具有预定的关系。 定时装置重复地提供多个定时信号，每个定时信号的每个顺序对限定已知持续时间的时间间隔。 计算装置耦合到定时装置和信令装置，用于接收至少一个顺序的定时信号对和至少一个运动信号。 因此，计算装置开始显示由第一轴每单位时间穿过的表面的区域，并因此当物体沿着第二轴移动时被处理。

    Stabilized fibronectin domain compositions, methods and uses
    8.
    发明授权
    Stabilized fibronectin domain compositions, methods and uses 有权
    稳定的纤连蛋白结构域组成，方法和用途

    公开(公告)号：US08569227B2

    公开(公告)日：2013-10-29

    申请号：US13097587

    申请日：2011-04-29

    Applicant: Steven Jacobs

    Inventor： Steven Jacobs

    IPC: A61K49/00 ,  C07K14/00 ,  C40B50/00 ,  C40B40/08 ,  C40B40/02 ,  C40B30/04 ,  C07H21/00 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61K38/16 ,  A61K38/22 ,  A61P25/00 ,  A61P7/00

    CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C07K16/18 ,  C07K2318/20 ,  Y02A50/473

    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

    Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用表现出增强的热和化学稳定性，同时呈现六个可修饰的环结构域，其可被工程化以形成能够结合靶标的结合配偶体，用于诊断和/或治疗组合物，方法和装置中的应用。

    Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    9.
    发明申请
    Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权
    抗TNFα纤维结合蛋白III型结构域支架组合物，方法和用途

    公开(公告)号：US20130274145A1

    公开(公告)日：2013-10-17

    申请号：US13845291

    申请日：2013-03-18

    Applicant: Steven Jacobs ,  Karyn O'Neil

    Inventor： Steven Jacobs ,  Karyn O'Neil

    IPC: G01N33/543

    CPC classification number: G01N33/54306 ,  A61K38/39 ,  C07K14/78 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

    Abstract translation: 基于来自人纤连蛋白（优选人腱生蛋白）的第十纤维连接蛋白III型（FN3）重复序列的蛋白质支架，其结合人TNFα，包括分离的编码蛋白质支架的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。

    Fibronectin type III domain based scaffold compositions, methods and uses
    10.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US08278419B2

    公开(公告)日：2012-10-02

    申请号：US12606382

    申请日：2009-10-27

    Applicant: Steven Jacobs ,  Karyn O'Neil

    Inventor： Steven Jacobs ,  Karyn O'Neil

    IPC: C07K14/00 ,  C07K17/00

    CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

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