公开(公告)号：US20190062274A1

公开(公告)日：2019-02-28

申请号：US16175144

申请日：2018-10-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasutomi ASANO ,  Takuto KOJIMA ,  Osamu KURASAWA ,  Tzu-Tshin WONG ,  Yasuhiro HIRATA ,  Naoki IWAMURA ,  Bunnai SAITO ,  Yuta TANAKA ,  Ryosuke ARAI ,  Shinichi IMAMURA ,  Kazuko YONEMORI ,  Yasufumi MIYAMOTO ,  Shuji KITAMURA ,  Osamu SANO

IPC: C07D211/58 ,  C07F9/6509 ,  C07D405/06 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D413/14 ,  C07F5/02 ,  C07D519/00 ,  C07D513/04 ,  C07D498/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/12 ,  C07D417/06 ,  C07D413/06 ,  C07D409/12 ,  C07D401/12 ,  C07D401/06 ,  C07D215/42 ,  A61K33/22 ,  A61K31/661 ,  A61K31/5355 ,  A61K31/517 ,  A61K31/506 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/452 ,  A61K31/451 ,  A61K31/4468 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/4433 ,  A61K31/443 ,  A61K31/437 ,  C07D401/14

CPC classification number: C07D211/58 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  A61P3/00 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  C07F9/6509 ,  Y02P20/55

Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US20180170874A1

公开(公告)日：2018-06-21

申请号：US15565891

申请日：2016-04-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasutomi ASANO ,  Takuto KOJIMA ,  Osamu KURASAWA ,  Tzu-Tshin WONG ,  Yasuhiro HIRATA ,  Naoki IWAMURA ,  Bunnai SAITO ,  Yuta TANAKA ,  Ryosuke ARAI ,  Shinichi IMAMURA ,  Kazuko YONEMORI ,  Yasufumi MIYAMOTO ,  Shuji KITAMURA ,  Osamu SANO

IPC: C07D211/58 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07D215/42 ,  C07D401/12 ,  C07D417/12 ,  C07D405/06 ,  C07D413/06 ,  C07D401/06 ,  C07D417/06 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07B59/00 ,  A61P35/00 ,  A61P3/00

CPC classification number: C07D211/58 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  A61P3/00 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  C07F9/6509

Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US20170121308A1

公开(公告)日：2017-05-04

申请号：US15318552

申请日：2015-06-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masaki OGINO ,  Eiji KIMURA ,  Shinkichi SUZUKI ,  Tomoko ASHIZAWA ,  Toshihiro IMAEDA ,  Ikuo FUJIMORI ,  Ryosuke ARAI

IPC: C07D401/10 ,  C07D213/81 ,  C07D405/14

CPC classification number: C07D401/10 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  C07D213/81 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as a medicament such as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the attached DESCRIPTION.