公开(公告)号：US20220289679A1

公开(公告)日：2022-09-15

申请号：US17630442

申请日：2020-07-28

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuta TANAKA ,  Yuta TANAKA ,  Keiko KAKEGAWA ,  Takahito KASAHARA ,  Fumiaki KIKUCHI ,  Takeshi YAMAMOTO ,  Tomohiro OHASHI ,  Zenichi IKEDA ,  Florian PUENNER ,  Minoru NAKAMURA ,  Kazuaki TAKAMI ,  Masataka MURAKAMI ,  Masaki DAINI ,  Masaki SETO ,  Satoshi MIKAMI ,  Minoru SASAKI

IPC: C07D213/82 ,  C07D401/12 ,  C07D471/04 ,  C07D413/12 ,  C07D405/14 ,  C07D401/14 ,  C07D237/14 ,  C07D405/12

Abstract: The present invention provides a compound having a glucosylceramide synthase inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of lysosomal storage diseases (e.g., Gaucher's disease, Fabry's disease, GM1-gangliosidosis, GM2 activator deficiency, Tay-Sachs disease, Sandhoffs disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

公开(公告)号：US20170362223A1

公开(公告)日：2017-12-21

申请号：US15538297

申请日：2015-12-21

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Eiji KIMURA ,  Yuhei MIYANOHANA ,  Masaki OGINO ,  Yuta TANAKA ,  Makoto FUSHIMI ,  Tomohiro OKAWA ,  Yuki HANYA ,  Tatsuki KOIKE

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61P25/00 ,  A61P29/00 ,  C07D487/04

Abstract: Provided is a compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and is useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, (excluding N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(imidazo[1,2-a]pyridin-5-yl)acetamide) or a salt thereof.

公开(公告)号：US20210087186A1

公开(公告)日：2021-03-25

申请号：US16961476

申请日：2019-01-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuta TANAKA ,  Tomohiro OHASHI ,  Zenichi IKEDA ,  Yuta TANAKA ,  Florian PÜNNER ,  Takeshi YAMAMOTO ,  Keiko KAKEGAWA ,  Fumiaki KIKUCHI ,  Nao MORISHITA ,  Takahito KASAHARA ,  Masaki SETO ,  Minoru NAKAMURA ,  Kazuaki TAKAMI ,  Masataka MURAKAMI ,  Masaki DAINI ,  Satoshi MIKAMI ,  Minoru SASAKI

IPC: C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00

Abstract: The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I) wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20220274982A1

公开(公告)日：2022-09-01

申请号：US17630840

申请日：2020-07-28

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuta TANAKA ,  Yuta TANAKA ,  Fumiaki KIKUCHI ,  Takeshi YAMAMOTO ,  Minoru NAKAMURA ,  Kazuaki TAKAMI ,  Masataka MURAKAMI ,  Masaki DAINI ,  Yasufumi WADA ,  Keiko KAKEGAWA ,  Takahito KASAHARA ,  Tomohiro OHASHI ,  Junsi WANG ,  Zenichi IKEDA ,  Florian PUENNER ,  Masaki SETO ,  Satoshi MIKAMI ,  Minoru SASAKI

IPC: C07D471/04

Abstract: The present invention provides a compound having a glucosylceramide synthase inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of lysosomal storage diseases (e.g., Gaucher's disease, Fabry's disease, GM1-gangliosidosis, GM2 activator deficiency, Tay-Sachs disease, Sandhoffs disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

公开(公告)号：US20190062274A1

公开(公告)日：2019-02-28

申请号：US16175144

申请日：2018-10-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasutomi ASANO ,  Takuto KOJIMA ,  Osamu KURASAWA ,  Tzu-Tshin WONG ,  Yasuhiro HIRATA ,  Naoki IWAMURA ,  Bunnai SAITO ,  Yuta TANAKA ,  Ryosuke ARAI ,  Shinichi IMAMURA ,  Kazuko YONEMORI ,  Yasufumi MIYAMOTO ,  Shuji KITAMURA ,  Osamu SANO

IPC: C07D211/58 ,  C07F9/6509 ,  C07D405/06 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D413/14 ,  C07F5/02 ,  C07D519/00 ,  C07D513/04 ,  C07D498/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/12 ,  C07D417/06 ,  C07D413/06 ,  C07D409/12 ,  C07D401/12 ,  C07D401/06 ,  C07D215/42 ,  A61K33/22 ,  A61K31/661 ,  A61K31/5355 ,  A61K31/517 ,  A61K31/506 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/452 ,  A61K31/451 ,  A61K31/4468 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/4433 ,  A61K31/443 ,  A61K31/437 ,  C07D401/14

CPC classification number: C07D211/58 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  A61P3/00 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  C07F9/6509 ,  Y02P20/55

Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US20180170874A1

公开(公告)日：2018-06-21

申请号：US15565891

申请日：2016-04-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasutomi ASANO ,  Takuto KOJIMA ,  Osamu KURASAWA ,  Tzu-Tshin WONG ,  Yasuhiro HIRATA ,  Naoki IWAMURA ,  Bunnai SAITO ,  Yuta TANAKA ,  Ryosuke ARAI ,  Shinichi IMAMURA ,  Kazuko YONEMORI ,  Yasufumi MIYAMOTO ,  Shuji KITAMURA ,  Osamu SANO

IPC: C07D211/58 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07D215/42 ,  C07D401/12 ,  C07D417/12 ,  C07D405/06 ,  C07D413/06 ,  C07D401/06 ,  C07D417/06 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07B59/00 ,  A61P35/00 ,  A61P3/00

CPC classification number: C07D211/58 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  A61P3/00 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  C07F9/6509

Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).