公开(公告)号：US20130280748A1

公开(公告)日：2013-10-24

申请号：US13800467

申请日：2013-03-13

Applicant: TECAN TRADING AG

Inventor： Harald Gebetsroither ,  Andreas Gfrorer ,  Juha Koota

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  C12M41/36 ,  C12M41/46 ,  G01N15/1456 ,  G01N21/253 ,  G01N21/59 ,  G01N21/6452 ,  G01N21/6456 ,  G01N33/5005 ,  G01N2015/144 ,  G01N2015/1486

Abstract: A method for investigating biological cells or cell cultures in a microplate reader receives at least one microplate with wells containing biological cells or cell cultures by a receiving device; positions the wells with respect to measuring devices of the microplate reader and detects integral measurement signals by at least one of the measuring devices. The biological cells or cell cultures in the specific wells of the microplate(s) are transilluminated by an illumination source of the microplate reader and imaged by an imaging camera. Each of the detected integral signals is compared with the image of the biological cells or cell cultures in the corresponding wells of the microplate(s) by a processor and is related to the imaged number, adherence, confluence or morphology of these biological cells or cell cultures.

Abstract translation: 用于在微板读数器中研究生物细胞或细胞培养物的方法通过接收装置接收含有生物细胞或细胞培养物的孔的至少一个微孔板; 将孔相对于微板读数器的测量装置定位，并通过至少一个测量装置检测积分测量信号。 微孔板的特定孔中的生物细胞或细胞培养物通过微孔板读数器的照明源透射并通过成像相机成像。 每个检测到的积分信号通过处理器与微孔板的相应孔中的生物细胞或细胞培养物的图像进行比较，并与这些生物细胞或细胞的成像数量，粘附，汇合或形态有关 文化。

公开(公告)号：US09568414B2

公开(公告)日：2017-02-14

申请号：US14697012

申请日：2015-04-27

Applicant: TECAN TRADING AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: G01N21/01 ,  G01N21/63 ,  G01N21/76 ,  G01N21/64 ,  G01N21/03

CPC classification number: G01N21/0303 ,  G01N21/6428 ,  G01N21/76 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  G01N2201/022 ,  G01N2201/0446 ,  Y10S436/807

Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

Abstract translation: 酶标板读取器具有壳体，至少一个光学测量/检测装置，微孔板支架，移动单元和一体式盖保持装置。 盖保持装置使微板在一个相应的至少大致垂直的方向上移动，以使微板盖远离微板。 盖保持装置作为磁性提升器布置在壳体内部，并且包括至少一个永磁体或至少三个电磁体或至少一个可切换永磁体的非阵列布置。 每个微板盖要移动离开微板包括具有物理区域的可磁化材料。 所述至少一个永磁体，电磁体或可切换永磁体的投影面积小于微板盖板的可磁化材料的物理面积。

公开(公告)号：US20150233815A1

公开(公告)日：2015-08-20

申请号：US14697012

申请日：2015-04-27

Applicant: TECAN TRADING AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: G01N21/03 ,  G01N21/76 ,  G01N21/64

CPC classification number: G01N21/0303 ,  G01N21/6428 ,  G01N21/76 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  G01N2201/022 ,  G01N2201/0446 ,  Y10S436/807

Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

Abstract translation: 酶标板读取器具有壳体，至少一个光学测量/检测装置，微孔板支架，移动单元和一体式盖保持装置。 盖保持装置使微板在一个相应的至少大致垂直的方向上移动，以使微板盖远离微板。 盖保持装置作为磁性提升器布置在壳体内部，并且包括至少一个永磁体或至少三个电磁体或至少一个可切换永磁体的非阵列布置。 每个微板盖要移动离开微板包括具有物理区域的可磁化材料。 所述至少一个永磁体，电磁体或可切换永磁体的投影面积小于微板盖板的可磁化材料的物理面积。

公开(公告)号：US09029101B2

公开(公告)日：2015-05-12

申请号：US13956551

申请日：2013-08-01

Applicant: Tecan Trading AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: C12M1/34 ,  G01N21/01 ,  G01N21/64 ,  G01N35/02 ,  G01N35/04 ,  G01N35/00

CPC classification number: G01N21/6428 ,  G01N35/028 ,  G01N35/04 ,  G01N2035/00287 ,  G01N2035/0405 ,  Y10S436/807

Abstract: Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing.

Abstract translation: 具有光学测量/检测装置的酶标仪具有外壳，微板支架和移动单元。 移动单元将微孔板支撑件移出壳体并在壳体内水平移动。 读取器在壳体内具有集成的盖保持装置，用于将微板盖提升并放置在微孔板上。 盖保持装置移动微板盖和/或微孔板支撑件，以在一个相应的垂直方向上移动微孔板。 用于光学测量这种微孔板读数器中的微孔板的方法将微孔板放置在微孔板支架上，将其缩回到壳体中，从盖板上提起盖子，用升高的盖子测量微孔板，取代盖子并延伸支架 并将被覆盖的微孔板从外壳中取出。

公开(公告)号：US10527550B2

公开(公告)日：2020-01-07

申请号：US13800467

申请日：2013-03-13

Applicant: TECAN TRADING AG

Inventor： Harald Gebetsroither ,  Andreas Gfrorer ,  Juha Koota

IPC: G01N21/64

Abstract: A method for investigating biological cells or cell cultures in a microplate reader receives at least one microplate with wells containing biological cells or cell cultures by a receiving device; positions the wells with respect to measuring devices of the microplate reader and detects integral measurement signals by at least one of the measuring devices. The biological cells or cell cultures in the specific wells of the microplate(s) are transilluminated by an illumination source of the microplate reader and imaged by an imaging camera. Each of the detected integral signals is compared with the image of the biological cells or cell cultures in the corresponding wells of the microplate(s) by a processor and is related to the imaged number, adherence, confluence or morphology of these biological cells or cell cultures.

公开(公告)号：US09964556B2

公开(公告)日：2018-05-08

申请号：US14654382

申请日：2014-10-30

Applicant: TECAN TRADING AG

Inventor： Gyoergy Wenczel ,  Harald Gebetsroither ,  Friedrich Menges

IPC: G01N35/02 ,  C12M1/34 ,  B01L9/00 ,  C12M1/32 ,  C12M1/00 ,  G01N35/04 ,  G01N35/00

CPC classification number: G01N35/028 ,  B01L9/523 ,  B01L2200/142 ,  B01L2300/041 ,  B01L2300/0829 ,  C12M23/12 ,  C12M23/38 ,  G01N35/04 ,  G01N2035/00356 ,  G01N2035/0403 ,  G01N2035/0477

Abstract: Microplate reader has measuring space, action source, measuring device for biological structure signals of microplate wells, transport support for positioning wells in relation to an optical axis of the device and controller for the action source, the measuring device and the transport support. An incubation apparatus with a frame accommodates a microplate with wells having bottoms for reducing liquid evaporation. The frame has a first opening surrounded by an inner wall for the microplate and an outer wall parallel to the inner wall and connected thereto by an intermediate bottom so that a channel is formed and the intermediate bottom for accommodating a liquid adjusted to the content of the microplate wells. The incubation apparatus has a support surface with a second opening for a microplate and, as a result, at least a portion of the well bottoms is freely accessible by the second opening.

公开(公告)号：US20190185228A1

公开(公告)日：2019-06-20

申请号：US16212372

申请日：2018-12-06

Applicant: TECAN TRADING AG

Inventor： Harald Gebetsroither ,  Manfred Lansing ,  Markus Schurf

IPC: B65D51/16 ,  G01N21/11 ,  G01N21/03 ,  B65D51/24 ,  B67C3/22

CPC classification number: B65D51/16 ,  B01L3/50825 ,  B01L2300/042 ,  B01L2300/048 ,  B65D39/00 ,  B65D51/1611 ,  B65D51/242 ,  B65D2539/001 ,  B67C3/222 ,  G01N21/03 ,  G01N21/11

Abstract: A closure element with at least one vent opening is a sealing plug that has a pin-shaped lower part with an underside. The at least one vent opening is formed by a duct in the sealing plug which, starting at an inlet opening into the duct, extends upwards from the underside of the pin-shaped lower part in the interior of the sealing plug and leads out of the sealing plug through a lateral outlet opening. A method is also disclosed for the complete and bubble-free filling of a container with a closure element and to the use of a filled container provided with a closure.

公开(公告)号：US09993824B2

公开(公告)日：2018-06-12

申请号：US14694365

申请日：2015-04-23

Applicant: TECAN TRADING AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: B01L9/00 ,  B01L1/00 ,  B01L99/00 ,  G01N35/02 ,  G01N35/04 ,  G01N21/01 ,  G01N35/00 ,  G01N21/03

CPC classification number: B01L9/523 ,  B01L1/00 ,  B01L99/00 ,  B01L2300/0663 ,  B01L2300/12 ,  B01L2300/16 ,  G01N21/0303 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  Y10S436/807

Abstract: A microplate reader comprises a housing; at least one optical measuring/detection device; a microplate support; a moving unit; and an integrated lid holding apparatus. The lid holding apparatus is arranged to move the microplate lid and/or the microplate support is arranged to move the microplate in one respective, in an at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electromagnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material.

公开(公告)号：US20150224507A1

公开(公告)日：2015-08-13

申请号：US14694365

申请日：2015-04-23

Applicant: TECAN TRADING AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: B01L9/00 ,  B01L99/00 ,  B01L1/00

CPC classification number: B01L9/523 ,  B01L1/00 ,  B01L99/00 ,  B01L2300/0663 ,  B01L2300/12 ,  B01L2300/16 ,  G01N21/0303 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  Y10S436/807

Abstract: A microplate reader (1) comprises a housing (3); at least one optical measuring/detection device (2); a microplate support (4); a moving unit (5); and an integrated lid holding apparatus (6). The lid holding apparatus (6) is arranged to move the microplate lid (7) and/or the microplate support (4) is arranged to move the microplate (8) in one respective, at least approximately vertical direction for moving the microplate lid (7) away from the microplate (8). The lid holding apparatus (6) is arranged inside the housing (3) as a magnetic lifter (6′) and comprises a non-array arrangement of at least one permanent magnet (9′), or at least three electro magnets (10′), or at least one switchable permanent magnet (11). Each microplate lid (7) to be moved away from the microplate (8) comprises magnetizable material (12).

Abstract translation: 酶标仪（1）包括壳体（3）; 至少一个光学测量/检测装置（2）; 微板支架（4）; 移动单元（5）; 和一体式盖保持装置（6）。 盖保持装置（6）被布置成移动微板盖（7）和/或微孔板支撑件（4），以将微孔板（8）在一个相应的至少大致垂直方向上移动，以移动微板盖 7）远离微孔板（8）。 盖保持装置（6）作为磁性提升器（6'）布置在壳体（3）的内部，并且包括至少一个永磁体（9'）的非排列布置，或至少三个电磁体（10' ）或至少一个可切换永磁体（11）。 要移动离开微孔板（8）的每个微板盖子（7）都包含可磁化材料（12）。

公开(公告)号：US20140045210A1

公开(公告)日：2014-02-13

申请号：US13956551

申请日：2013-08-01

Applicant: TECAN TRADING AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N35/028 ,  G01N35/04 ,  G01N2035/00287 ,  G01N2035/0405 ,  Y10S436/807

Abstract: Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing.

Abstract translation: 具有光学测量/检测装置的酶标仪具有外壳，微板支架和移动单元。 移动单元将微孔板支撑件移出壳体并在壳体内水平移动。 读取器在壳体内具有集成的盖保持装置，用于将微板盖提升并放置在微孔板上。 盖保持装置移动微板盖和/或微孔板支撑件，以在一个相应的垂直方向上移动微孔板。 用于光学测量这种微孔板读数器中的微孔板的方法将微孔板放置在微孔板支架上，将其缩回到壳体中，从盖板上提起盖子，用升高的盖子测量微孔板，取代盖子并延伸支架 并将被覆盖的微孔板从外壳中取出。