专利检索 ap:("Tae-Gon Baik" OR "Chris A. Buhr" OR "Katherine Lara" OR "Sunghoon Ma" OR "Morrison Mac" OR "John M. Nuss" OR "Longcheng Wang" OR "Yong Wang" OR "Bryan K.S. Yeung") AND inv:"Tae-Gon Baik" 第 1 页

1.

发明申请
Pyridopyrimidinone Inhibitors of PI3Kalpha 审中-公开
标题翻译：吡啶并嘧啶酮PI3Kα的抑制剂

公开(公告)号：US20110237608A1

公开(公告)日：2011-09-29

申请号：US13152045

申请日：2011-06-02

申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung

发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung

IPC分类号： A61K31/519 , C07D471/04 , A61P35/00 , A61P35/02

CPC分类号： C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858

摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

2.

发明申请
Pyridopyrimidinone Inhibitors of Pl3Kalpha 有权
标题翻译：吡啶并嘧啶酮Pl3Kα的抑制剂

公开(公告)号：US20090270430A1

公开(公告)日：2009-10-29

申请号：US11988848

申请日：2006-10-09

申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung

发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung

IPC分类号： A61K31/519 , C07D471/04 , A61P35/00

CPC分类号： C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858

摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

3.

发明授权
Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha 有权
标题翻译：取代的吡啶并[2,3-d]嘧啶-7（8H） - 酮磷酸肌醇3-激酶α抑制剂

公开(公告)号：US08044062B2

公开(公告)日：2011-10-25

申请号：US11988848

申请日：2006-10-09

申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K. S. Yeung

发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K. S. Yeung

IPC分类号： C07D471/04 , A61K31/519 , A61P35/00

CPC分类号： C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858

摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

4.

发明申请
Pyridopyrimidinone inhibitors of pi3kalpha 失效
标题翻译： pi3kalpha的吡啶并嘧啶酮抑制剂

公开(公告)号：US20090062274A1

公开(公告)日：2009-03-05

申请号：US11988859

申请日：2006-10-09

申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung

发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung

IPC分类号： A61K31/5377 , C07D471/04 , A61K31/519

CPC分类号： C07D471/04

摘要： The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

5.

发明申请
Azepinoindole Derivatives As Pharmaceutical Agents 审中-公开
标题翻译： Azepinoindole衍生物作为药剂

公开(公告)号：US20090203577A1

公开(公告)日：2009-08-13

申请号：US12096961

申请日：2006-12-12

申请人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang

发明人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang

IPC分类号： A61K31/55 , C07D487/04 , A61P3/00 , A61K38/22 , A61K38/28

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.

摘要翻译： 本发明涉及对法呢酯X受体表现出亲和性的式I化合物。

6.

发明授权
Protein kinase modulators and methods of use 失效
标题翻译：蛋白激酶调节剂和使用方法

公开(公告)号：US07704995B2

公开(公告)日：2010-04-27

申请号：US10513081

申请日：2003-05-02

申请人： Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller

发明人： Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller

IPC分类号： C07D279/16 , C07D279/12 , C07D417/12 , C07D265/36 , C07D413/12 , C07D403/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D419/12 , C07D241/18 , C07D241/20 , A61K31/55 , A61K31/497 , A61K31/5355 , A61K31/541 , C07D305/12 , C07D307/79 , A61K31/44 , A61P35/00

CPC分类号： C07D241/26 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12

摘要： This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

摘要翻译： 本发明涉及用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物，以及含有这些化合物的药物组合物。更具体地，本发明涉及抑制，调节和/或调节激酶，特别是检查点激酶，甚至更特别是检查点激酶1或Chk1的化合物。治疗或预防性地使用化合物和组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面，并且包括通过以下方法治疗癌症以及与不期望的血管生成和/或细胞增殖相关的其它疾病状态，施用有效量的这些化合物。

7.

发明授权
Pyrazole kinase modulators and methods of use 失效
标题翻译：吡唑激酶调节剂和使用方法

公开(公告)号：US08710038B2

公开(公告)日：2014-04-29

申请号：US11575411

申请日：2005-09-15

申请人： Tae-Gon Baik , Chris A. Buhr , Sunghoon Ma , John M. Nuss , Zerom Tesfai , Longcheng Wang , Bryan K. S. Yeung

发明人： Tae-Gon Baik , Chris A. Buhr , Sunghoon Ma , John M. Nuss , Zerom Tesfai , Longcheng Wang , Bryan K. S. Yeung

IPC分类号： C07D403/00 , A01N43/00 , A61K31/33

CPC分类号： C07D403/04 , C07D231/12 , C07D401/04 , C07D405/04 , C07D409/04

摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。本发明的化合物抑制，调节和/或调节激酶。使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

8.

发明授权
Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer 失效
标题翻译：用于治疗癌症的PI3Kα吡啶并嘧啶酮抑制剂

公开(公告)号：US08247408B2

公开(公告)日：2012-08-21

申请号：US11988859

申请日：2006-10-09

申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung

发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung

IPC分类号： C07D471/04 , C07D471/14 , C07D413/14 , A61K31/519 , A61K31/5355 , A61P35/00 , A61P29/00 , A61P3/10

CPC分类号： C07D471/04

摘要： The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。