公开(公告)号：US06949364B2

公开(公告)日：2005-09-27

申请号：US10876841

申请日：2004-06-28

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

IPC分类号： C07K14/47 ,  C12N15/09 ,  C12N15/12 ,  C12P21/06 ,  C12P21/02 ,  C07H21/04 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节。

公开(公告)号：US07288635B2

公开(公告)日：2007-10-30

申请号：US11192374

申请日：2005-07-29

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

IPC分类号： C07K16/18

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis and to encode a protein, Tesmin, which may regulate the differentiation of spermatogeneous cells into primary spermatocytes. Tesmin proteins are described herein, as are antibodies that bind to such proteins.

摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节和编码一种蛋白质Tesmin，其可以调节精原细胞分化为原始精母细胞。 本文描述了Tesmin蛋白质，以及与这些蛋白质结合的抗体。

公开(公告)号：US06835813B1

公开(公告)日：2004-12-28

申请号：US09743237

申请日：2001-06-04

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

IPC分类号： C07K1447

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节。

公开(公告)号：US20050033036A1

公开(公告)日：2005-02-10

申请号：US10876841

申请日：2004-06-28

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil Kaul ,  Youji Mitsui

IPC分类号： C07K14/47 ,  C12N15/09 ,  C12N15/12 ,  C12P21/06 ,  C07K14/475 ,  C07H21/04

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

公开(公告)号：US20050272126A1

公开(公告)日：2005-12-08

申请号：US11192374

申请日：2005-07-29

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil Kaul ,  Youji Mitsui

IPC分类号： C07K14/47 ,  C12N15/09 ,  C12N15/12 ,  C12P21/06

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

公开(公告)号：US4981950A

公开(公告)日：1991-01-01

申请号：US249429

申请日：1988-09-26

申请人： Tomoh Masaki ,  Katsutoshi Goto ,  Sadao Kimura ,  Youji Mitsui ,  Yoshio Yazaki ,  Masashi Yanagisawa ,  Hiroki Kurihara

发明人： Tomoh Masaki ,  Katsutoshi Goto ,  Sadao Kimura ,  Youji Mitsui ,  Yoshio Yazaki ,  Masashi Yanagisawa ,  Hiroki Kurihara

IPC分类号： A61K38/00 ,  C07K14/575

CPC分类号： C07K14/57536 ,  A61K38/00

摘要： Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.