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    Methods and Compositions for Treating Withdrawal Syndromes Using Non-Sedative Dexmedetomidine Transdermal Compositions
    1.
    发明申请
    Methods and Compositions for Treating Withdrawal Syndromes Using Non-Sedative Dexmedetomidine Transdermal Compositions 审中-公开
    使用非镇静性美替米丹透皮组合物治疗戒断综合征的方法和组合

    公开(公告)号：US20150098983A1

    公开(公告)日：2015-04-09

    申请号：US14505943

    申请日：2014-10-03

    申请人： Teikoku Pharma USA, Inc.

    发明人： Adchara Pongpeerapat ,  Amit Jain ,  Bret Berner ,  Jianye Wen ,  Jutaro Shudo

    IPC分类号： A61K31/4174 ,  A61K9/70

    CPC分类号： A61K31/4174 ,  A61K9/7053 ,  A61K9/7061 ,  A61K47/12 ,  A61K47/32

    摘要： Aspects of the invention include methods of treating withdrawal syndrome by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a non-sedative amount of dexmedetomidine to a subject diagnosed as having withdrawal syndrome. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to treat withdrawal syndrome in the subject. Also provided are transdermal delivery devices configured to deliver a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.

    摘要翻译： 本发明的方面包括通过应用含有右美托咪定组合物的透皮递送装置来治疗戒断综合征的方法，以将非镇静剂量的右美托咪定输送到被诊断为具有戒断综合征的受试者。 在根据某些实施方案的实践方法中，将具有右美托咪定组合物的透皮递送装置施用于受试者，并以足以递送非镇静剂量的右美托咪定以治疗受试者的戒断综合征的方式与受试者保持接触。 还提供了经皮递送装置，其经配置以递送非镇静剂量的足以实施本发明方法的右美托咪定，以及含有透皮递送装置的试剂盒。

    Methods of Managing Pain Using Dexmedetomidine Transdermal Delivery Devices
    2.
    发明申请
    Methods of Managing Pain Using Dexmedetomidine Transdermal Delivery Devices 审中-公开

    公开(公告)号：US20180117012A1

    公开(公告)日：2018-05-03

    申请号：US15799602

    申请日：2017-10-31

    申请人： Teikoku Pharma USA, Inc.

    发明人： Jutaro Shudo ,  Wan-Ning Song ,  Rose Marie Gonsalves ,  Stephen Shipping Hwang

    IPC分类号： A61K31/4174 ,  A61K9/70 ,  A61K45/06

    CPC分类号： A61K31/4174 ,  A61K9/7038 ,  A61K9/7053 ,  A61K9/7061 ,  A61K45/06 ,  A61P29/00

    摘要： Aspects of the invention include methods of managing pain in a subject by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a pain relieving effective amount of dexmedetomidine to a subject. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver an amount of dexmedetomidine effective to manage pain in the subject. In some embodiments, methods include hydrating the subject, such as by administering a hydration fluid composition to the subject. Methods according to certain embodiments may also include co-administering an opioid to the subject. Also provided is a transdermal delivery device configured to deliver dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery device.

    Methods and Compositions for Transdermal Delivery of a Non-Sedative Amount of Dexmedetomidine
    4.
    发明申请
    Methods and Compositions for Transdermal Delivery of a Non-Sedative Amount of Dexmedetomidine 审中-公开
    用于经皮给药的非镇静剂量的右美托咪定的方法和组合物

    公开(公告)号：US20150098981A1

    公开(公告)日：2015-04-09

    申请号：US14505936

    申请日：2014-10-03

    申请人： Teikoku Pharma USA, Inc.

    发明人： Adchara Pongpeerapat ,  Amit Jain ,  Bret Berner ,  Jianye Wen ,  Jutaro Shudo

    IPC分类号： A61K31/4174 ,  A61K9/70

    CPC分类号： A61K31/4174 ,  A61K9/7053 ,  A61K9/7061 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32

    摘要： Aspects of the invention include methods for applying to a subject a transdermal delivery device configured to deliver a non-sedative amount of a dexmedetomidine composition. In practicing methods according to certain embodiments, a non-sedative amount of a dexmedetomidine composition is transdermally applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to a subject. Also provided are transdermal delivery devices having a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.

    摘要翻译： 本发明的方面包括向受试者施用经配置以递送非镇静剂量右美托咪定组合物的透皮递送装置的方法。 在根据某些实施方案的实践方法中，非镇静剂量的右美托咪定组合物经皮施用于受试者，并且以足以将非镇静剂量的右美托咪定输送给受试者的方式与受试者保持接触。 还提供了具有足够实践本发明方法的非镇静剂量的右美托咪定的透皮递送装置，以及含有透皮递送装置的试剂盒。

    Methods of Administering a Dermatological Agent to a Subject
    5.
    发明申请
    Methods of Administering a Dermatological Agent to a Subject 有权
    向主体施用皮肤病学药剂的方法

    公开(公告)号：US20130115268A1

    公开(公告)日：2013-05-09

    申请号：US13728582

    申请日：2012-12-27

    申请人： Teikoku Pharma USA, INC. ,  Teikikoku Seiyaku Kabushiki Kaisha

    发明人： John Koo ,  Jutaro Shudo ,  Sadanobu Shirai

    IPC分类号： A61K47/00

    CPC分类号： A61K47/00 ,  A61K8/0208 ,  A61K8/042 ,  A61K9/0014 ,  A61K9/7023 ,  A61Q19/00

    摘要： Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.

    摘要翻译： 提供了向受试者施用皮肤病药物的方法。 在本发明方法中，将有效量的皮肤病药物的局部制剂局部施用于宿主。 皮肤病药物的局部施用制剂然后用水凝胶贴片封闭，其中水凝胶贴片的特征是其缺乏药物活性剂。 还提供了通过向受试者施用皮肤病学试剂治疗受试者的疾病状态的方法。 还提供了用于实践主题方法的套件。 主题方法和组合物可用于各种不同的应用。

    Methods of administering a dermatological agent to a subject
    8.
    发明授权
    Methods of administering a dermatological agent to a subject 有权
    向受试者施用皮肤病药物的方法

    公开(公告)号：US09023392B2

    公开(公告)日：2015-05-05

    申请号：US13728582

    申请日：2012-12-27

    申请人： Teikoku Pharma USA, Inc. ,  Teikikoku Seiyaku Kabushiki Kaisha

    发明人： John Koo ,  Jutaro Shudo ,  Sadanobu Shirai

    IPC分类号： A61K9/14 ,  A61K47/00 ,  A61K8/02 ,  A61K8/04 ,  A61K9/00 ,  A61K9/70 ,  A61Q19/00

    CPC分类号： A61K47/00 ,  A61K8/0208 ,  A61K8/042 ,  A61K9/0014 ,  A61K9/7023 ,  A61Q19/00

    摘要： Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.

    摘要翻译： 提供了向受试者施用皮肤病药物的方法。 在本发明方法中，将有效量的皮肤病药物的局部制剂局部施用于宿主。 皮肤病药物的局部施用制剂然后用水凝胶贴片封闭，其中水凝胶贴片的特征是其缺乏药物活性剂。 还提供了通过向受试者施用皮肤病学试剂治疗受试者的疾病状态的方法。 还提供了用于实践主题方法的套件。 主题方法和组合物可用于各种不同的应用。

    Methods and Compositions for Treating Attention Deficit Hyperactivity Disorder, Anxiety and Insomnia Using Dexmedetomidine Transdermal Compositions
    9.
    发明申请
    Methods and Compositions for Treating Attention Deficit Hyperactivity Disorder, Anxiety and Insomnia Using Dexmedetomidine Transdermal Compositions 审中-公开
    治疗注意力缺陷多动障碍，使用右美托咪定透皮组合物的焦虑和失眠的方法和组合

    公开(公告)号：US20150098997A1

    公开(公告)日：2015-04-09

    申请号：US14505933

    申请日：2014-10-03

    申请人： Teikoku Pharma USA, Inc.

    发明人： Adchara Pongpeerapat ,  Amit Jain ,  Bret Berner ,  Jianye Wen ,  Jutaro Shudo

    IPC分类号： A61K31/4174 ,  A61K9/70

    CPC分类号： A61K31/4174 ,  A61K9/7053 ,  A61K9/7061 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32

    摘要： Aspects of the invention include methods of treating ADHD, anxiety or insomnia by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver an amount of dexmedetomidine to a subject diagnosed as having ADHD, anxiety or insomnia. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver an amount of dexmedetomidine sufficient to treat ADHD, anxiety or insomnia in the subject. Also provided are transdermal delivery devices configured to deliver an amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.

    摘要翻译： 本发明的方面包括通过应用含有右美托咪定组合物的透皮递送装置来治疗ADHD，焦虑或失眠的方法，以将一定量的右美托咪定输送到诊断为患有ADHD，焦虑或失眠的受试者。 在根据某些实施方案的实践方法中，将具有右美托咪定组合物的透皮递送装置应用于受试者，并且以足以递送足以治疗受试者的ADHD，焦虑或失眠的右美托咪定量的方式与受试者保持接触 。 还提供了经皮递送装置，其被配置为递送足量用于实施本发明方法的右美托咪定量，以及包含透皮递送装置的试剂盒。

    Methods and Compositions for Managing Pain Comprising Dexmedetomidine Transdermal Compositions
    10.
    发明申请
    Methods and Compositions for Managing Pain Comprising Dexmedetomidine Transdermal Compositions 审中-公开
    用于治疗包含右美托咪定透皮组合物的疼痛的方法和组合物

    公开(公告)号：US20150098982A1

    公开(公告)日：2015-04-09

    申请号：US14505941

    申请日：2014-10-03

    申请人： Teikoku Pharma USA, Inc.

    发明人： Adchara Pongpeerapat ,  Amit Jain ,  Bret Berner ,  Jianye Wen ,  Jutaro Shudo

    IPC分类号： A61K31/4174 ,  A61K9/70 ,  A61K45/06

    CPC分类号： A61K31/4174 ,  A61K9/7053 ,  A61K9/7061 ,  A61K45/06 ,  A61K47/12 ,  A61K47/32

    摘要： Aspects of the invention include methods of managing pain in a subject by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a pain relieving effective amount of dexmedetomidine to a subject experiencing pain. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver an amount of dexmedetomidine effective to manage pain in the subject. Also provided are transdermal delivery devices configured to deliver dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.

    摘要翻译： 本发明的方面包括通过应用含有右美托咪定组合物的透皮递送装置来治疗受试者的疼痛的方法，该组合物经配制以将疼痛缓解的有效量的右美托咪定递送至经历疼痛的受试者。 在根据某些实施方案的实践方法中，将具有右美托咪定组合物的透皮递送装置施用于受试者，并以足以递送一定量的右美托咪定以有效治疗受试者的疼痛的方式与受试者保持接触。 还提供了经皮递送装置，其经配置以递送足够实践本发明方法的右美托咪定，以及含有透皮递送装置的试剂盒。