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公开(公告)号：US09956277B2
公开(公告)日：2018-05-01
申请号：US14849123
申请日：2015-09-09
Applicant: The Curators of the University of Missouri
Inventor： George C. Stewart , Brian Matthew Thompson
CPC classification number: A61K39/07 , A61K39/00 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C07K14/32 , C07K2319/035 , C12N3/00 , C12N11/16 , C12N15/75 , C12N2770/10022 , C12N2770/10034 , Y02E50/16 , Y02E50/17
Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.
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公开(公告)号：US20160053222A1
公开(公告)日：2016-02-25
申请号：US14849295
申请日：2015-09-09
Applicant: The Curators of the University of Missouri
Inventor： George C. Stewart , Brian Matthew Thompson , Chung-Ho Lin
CPC classification number: A61K39/07 , A61K39/00 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C07K14/32 , C07K2319/035 , C12N3/00 , C12N11/16 , C12N15/75 , C12N2770/10022 , C12N2770/10034 , Y02E50/16 , Y02E50/17
Abstract: Herein a Bacillus exosporium molecule delivery (BEMD) system that provides a means to deliver molecules of interest (MOIs) to an environment is disclosed. The system results in the display of MOIs on the exosporium surface of Bacillus family members such that they can be delivered to an environment in a stable and active form. In addition, methods of making and using the system are described.
Abstract translation: 本文公开了提供将感兴趣分子（MOI）传递给环境的手段的芽孢杆菌外芽分子递送（BEMD）系统。 该系统导致在芽孢杆菌家族成员的外胚层表面上显示MOI，使得它们可以以稳定和活性形式递送到环境中。 另外，描述制造和使用该系统的方法。
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Patent Agency Ranking
公开(公告)号：US10081790B2
公开(公告)日：2018-09-25
申请号：US14849295
申请日：2015-09-09
Applicant: The Curators of the University of Missouri
Inventor： George C. Stewart , Brian Matthew Thompson , Chung-Ho Lin
IPC: C12P7/10 , C12N1/20 , C12P3/00 , C12R1/085 , C02F3/34 , B09C1/10 , C02F101/22 , C02F101/30 , C02F101/20
Abstract: Herein a Bacillus exosporium molecule delivery (BEMD) system that provides a means to deliver molecules of interest (MOIs) to an environment is disclosed. The system results in the display of MOIs on the exosporium surface of Bacillus family members such that they can be delivered to an environment in a stable and active form. In addition, methods of making and using the system are described.
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公开(公告)号：US12103222B2
公开(公告)日：2024-10-01
申请号：US17416301
申请日：2019-12-23
Inventor： Ronald Wood , Hsin-Yeh Hsieh , Chung-Ho Lin , George C. Stewart , Mason W. Schellenberg , Shibu Jose
IPC: B29C64/118 , B29C64/209 , B29C64/295 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
CPC classification number: B29C64/118 , B29C64/209 , B29C64/295 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
Abstract: A drawn fused filament fabrication method of three-dimensional printing is disclosed in which the filament extruded is variable and not restricted to the diameter of the nozzle used for extrusion. This method composes three steps. The first is to extrude a small amount of material at a starting position. Next, the extruding head pulls the extruded material along while moving away from the starting position. During this time to material cools down and solidifies. As a result, a thin filament is formed. Third, once the extruding head moves to a destination, a small amount of material can be extruded and deposited to anchor this newly formed filament to a surface. The drawn fused filament fabrication method may be used to print three-dimensional parts having significant lower thickness than the diameter of the nozzle used to extrude the printing material.
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公开(公告)号：US20220072764A1
公开(公告)日：2022-03-10
申请号：US17416301
申请日：2019-12-23
Inventor： Ronald Wood , Hsin-Yeh Hsieh , Chung-Ho Lin , George C. Stewart , Mason W. Schellenberg , Shibu Jose
IPC: B29C64/118 , B29C64/209 , B29C64/295 , B29C64/393 , B33Y50/02 , B33Y30/00 , B33Y10/00
Abstract: A drawn fused filament fabrication method of three-dimensional printing is disclosed in which the filament extruded is variable and not restricted to the diameter of the nozzle used for extrusion. This method composes three steps. The first is to extrude a small amount of material at a starting position. Next, the extruding head pulls the extruded material along while moving away from the starting position. During this time to material cools down and solidifies. As a result, a thin filament is formed. Third, once the extruding head moves to a destination, a small amount of material can be extruded and deposited to anchor this newly formed filament to a surface. The drawn fused filament fabrication method may be used to print three-dimensional parts having significant lower thickness than the diameter of the nozzle used to extrude the printing material.
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公开(公告)号：US20180250377A1
公开(公告)日：2018-09-06
申请号：US15965034
申请日：2018-04-27
Applicant: The Curators of the University of Missouri
Inventor： George C. Stewart , Brian Matthew Thompson
Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.
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公开(公告)号：US20160051656A1
公开(公告)日：2016-02-25
申请号：US14849123
申请日：2015-09-09
Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
Inventor： George C. Stewart , Brian Matthew Thompson
CPC classification number: A61K39/07 , A61K39/00 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C07K14/32 , C07K2319/035 , C12N3/00 , C12N11/16 , C12N15/75 , C12N2770/10022 , C12N2770/10034 , Y02E50/16 , Y02E50/17
Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.
Abstract translation: 本发明提供了芽孢杆菌外芽抗原递送（BEAD）系统，其提供将重组蛋白质或小分子引入细菌蜡状芽孢杆菌家族（即炭疽杆菌，蜡状芽胞杆菌和苏云金芽孢杆菌）成员的外植体的方法 披露 该系统导致重组蛋白或小分子的表面显示，使得它们可以刺激免疫应答。 另外，描述制造和使用该系统的方法。
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