公开(公告)号：US20140292333A1

公开(公告)日：2014-10-02

申请号：US14231118

申请日：2014-03-31

申请人： Thomas Beck ,  Rainer Schneider

发明人： Thomas Beck ,  Rainer Schneider

IPC分类号： G01R33/54

CPC分类号： G01R33/543 ,  G01R33/243 ,  G01R33/246 ,  G01R33/583

摘要： A method for establishing a magnetic resonance system actuation sequence is described. A first number of field distribution maps are acquired for slices of the measurement region, and a radiofrequency pulse train is established on the basis thereof for the magnetic resonance system actuation sequence. This acquisition of the first number of field distribution maps may be brought about on the basis of an acquisition scheme. A reduced number of field distribution representation maps are established on the basis of the acquired field distribution maps, which field distribution representation maps represent the first number of acquired field distribution maps in accordance with a predetermined optimization criterion, and the radiofrequency pulse train is established on the basis of the field distribution representation maps.

摘要翻译： 描述了一种用于建立磁共振系统致动顺序的方法。 对于测量区域的切片获取第一数量的场分布图，并且基于磁共振系统致动序列建立射频脉冲串。 可以在采集方案的基础上获得对第一数量的现场分布图的获取。 基于所获取的场分布图建立减少数量的场分布表示图，该场分布表示映射根据预定的优化准则表示所获取的场分布图的第一数量，并且射频脉冲序列建立在 现场分布表示图的基础。

公开(公告)号：US09791531B2

公开(公告)日：2017-10-17

申请号：US14231118

申请日：2014-03-31

申请人： Thomas Beck ,  Rainer Schneider

发明人： Thomas Beck ,  Rainer Schneider

IPC分类号： G01R33/24 ,  G01R33/54 ,  G01R33/58

CPC分类号： G01R33/543 ,  G01R33/243 ,  G01R33/246 ,  G01R33/583

摘要： A method for establishing a magnetic resonance system actuation sequence is described. A first number of field distribution maps are acquired for slices of the measurement region, and a radiofrequency pulse train is established on the basis thereof for the magnetic resonance system actuation sequence. This acquisition of the first number of field distribution maps may be brought about on the basis of an acquisition scheme. A reduced number of field distribution representation maps are established on the basis of the acquired field distribution maps, which field distribution representation maps represent the first number of acquired field distribution maps in accordance with a predetermined optimization criterion, and the radiofrequency pulse train is established on the basis of the field distribution representation maps.

公开(公告)号：US09109391B2

公开(公告)日：2015-08-18

申请号：US12693556

申请日：2010-01-26

申请人： Thomas Beck ,  Christina Biermann

发明人： Thomas Beck ,  Christina Biermann

IPC分类号： G06K9/00 ,  E06B5/16 ,  E06B3/56 ,  E06B3/263 ,  E06B3/70

CPC分类号： E06B5/161 ,  A61B6/00 ,  E06B3/56 ,  E06B2003/2631 ,  E06B2003/7078 ,  G06K9/4638 ,  G06K9/62 ,  G06K2209/055 ,  G06T7/11 ,  G06T7/12 ,  G06T7/136 ,  G06T7/187 ,  G06T7/33 ,  G06T2207/30101

摘要： A method is disclosed for determining a branching point within a hollow organ in image data representing the spatial structure thereof. In at least one embodiment, the method includes setting a start point within the hollow organ; determining at least one local threshold which corresponds to the presence of a wall of the hollow organ; carrying out a region growing method using the threshold; analyzing the connectivity of a number of outer growth layers; and localizing a branching on the basis of the connectivity analysis. Moreover, at least one embodiment of the invention relates to a correspondingly designed branching determination unit.

摘要翻译： 公开了一种用于在表示其空间结构的图像数据中确定中空器官内的分支点的方法。 在至少一个实施例中，该方法包括设置中空器官内的起始点; 确定对应于所述中空器官的壁的存在的至少一个局部阈值; 使用阈值进行区域增长方法; 分析多个外生长层的连通性; 并在连通性分析的基础上本地化分支。 此外，本发明的至少一个实施例涉及相应设计的分支确定单元。

公开(公告)号：US08618439B2

公开(公告)日：2013-12-31

申请号：US13397057

申请日：2012-02-15

申请人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

发明人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

IPC分类号： B23K26/38 ,  B23K15/08

CPC分类号： B23K15/085 ,  B23K26/384 ,  B23K26/389 ,  B23K2101/001 ,  F01D5/186 ,  F05D2230/13 ,  Y02T50/67 ,  Y02T50/676 ,  Y10T29/49341

摘要： There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

摘要翻译： 有多种形成通孔的方法。 特别是在制造多个薄膜冷却孔时，如在燃气轮机叶片或燃烧室元件中，小的时间优点在制造孔时也是重要的。 根据本发明的方法，为了使其在顶部和底部区域中的每一种情况下，使得孔接近于最终轮廓，以便随后用其他激光参数产生最终轮廓，这实现了时间优点。

公开(公告)号：US20130012438A1

公开(公告)日：2013-01-10

申请号：US13458086

申请日：2012-04-27

申请人： Henry Blair ,  Thomas Beck ,  Robert Charles Ladner

发明人： Henry Blair ,  Thomas Beck ,  Robert Charles Ladner

IPC分类号： A61K38/17 ,  A61P29/00 ,  A61P9/10 ,  A61K38/11

CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的缺血 脑缺血，全身炎症反应发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，特别是需要体外循环的手术。

公开(公告)号：US08237082B2

公开(公告)日：2012-08-07

申请号：US12223204

申请日：2007-01-05

申请人： Thomas Beck ,  Silke Settegast

发明人： Thomas Beck ,  Silke Settegast

IPC分类号： B23K26/38

CPC分类号： B23K26/0648 ,  B23K26/0622 ,  B23K26/064 ,  B23K26/0665 ,  B23K26/389

摘要： There is described a method for producing a hole using e.g. a lasers, wherein short laser pulse durations are used. The laser pulse durations are varied, short laser pulse durations being utilized only in the area to be removed in which an influence on the penetration behavior and discharge behavior is noticeable while longer pulse durations of >0.4 ms are used. This is the case for the inner surface of a diffuser of a hole, for example, which can be produced very accurately by means of short laser pulse durations.

摘要翻译： 描述了使用例如制造孔的方法。 激光器，其中使用短激光脉冲持续时间。 激光脉冲持续时间是变化的，短激光脉冲持续时间仅在要去除的区域中被使用，其中在使用> 0.4ms的较长脉冲持续时间时，对穿透行为和放电行为的影响是显着的。 这是例如孔的扩散器的内表面的情况，例如，可以通过短的激光脉冲持续时间非常精确地制造。

公开(公告)号：US08188045B2

公开(公告)日：2012-05-29

申请号：US11804388

申请日：2007-05-18

申请人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

发明人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

IPC分类号： A61K38/16 ,  A61P7/02 ,  C07K14/00

CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的缺血 脑缺血，全身炎症反应发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，特别是需要体外循环的手术。

公开(公告)号：US08157526B2

公开(公告)日：2012-04-17

申请号：US11918302

申请日：2006-03-16

申请人： Thomas Beck ,  Silke Settegast

发明人： Thomas Beck ,  Silke Settegast

IPC分类号： F01D5/18

CPC分类号： F01D5/186 ,  F01D5/286 ,  F01D5/288 ,  F05D2230/90 ,  F05D2250/324 ,  F05D2300/13 ,  F05D2300/21 ,  F23R3/04 ,  F23R2900/03042 ,  Y02T50/67 ,  Y02T50/676

摘要： Conventionally coated components with film cooling holes are known, comprising a diffuser, extending through the layers into the substrate. According to the invention, the component is embodied such that the whole diffuser is largely arranged in the layer.

摘要翻译： 具有膜冷却孔的常规涂覆部件是已知的，包括扩散器，其延伸穿过所述层进入衬底。 根据本发明，该部件被实施为使得整个扩散器大部分布置在该层中。

公开(公告)号：US07816625B2

公开(公告)日：2010-10-19

申请号：US10574724

申请日：2004-09-02

申请人： Thomas Beck ,  Georg Bostanjoglo

发明人： Thomas Beck ,  Georg Bostanjoglo

IPC分类号： B23K26/00 ,  B23K26/06

CPC分类号： B23K26/0608 ,  B23K26/0622 ,  B23K26/389 ,  B23K26/40 ,  B23K2101/001 ,  B23K2103/172 ,  B23K2103/52

摘要： Previous methods for the production of a hole in a component are very time-consuming and expensive, as special lasers having ultra short laser pulse lengths are used. The inventive method varies laser pulse lengths and ultra short laser pulse lengths are used exclusively in the region which is to be removed, wherein it is possible to have a noticeable influence on through flow and/or out-flow behavior. This, for example, the inner surface of a diffuser of a hole, which can be produced in a precise manner using ultra short laser pulse lengths.

摘要翻译： 由于使用具有超短激光脉冲长度的特殊激光器，因此在组件中产生孔的先前方法非常耗时且昂贵。 本发明的方法改变激光脉冲长度，并且超短激光脉冲长度仅用于要去除的区域中，其中可能对通过流动和/或流出行为具有明显的影响。 例如，可以使用超短激光脉冲长度精确地制造孔的扩散器的内表面。

公开(公告)号：US20090234009A1

公开(公告)日：2009-09-17

申请号：US11932015

申请日：2007-10-31

申请人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

发明人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

IPC分类号： A61K31/197

CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.