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公开(公告)号：US07598423B2
公开(公告)日：2009-10-06
申请号：US11718753
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
IPC分类号： C07D239/26 , C07D239/28 , C07D241/10 , C07D401/10 , C07D213/02 , C07D291/04 , C07D271/06 , C07D277/20 , C07D417/10 , C07D333/06 , C07D319/06 , C07C49/76
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
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公开(公告)号：US07816523B2
公开(公告)日：2010-10-19
申请号：US12549552
申请日：2009-08-28
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D239/32 , C07D213/02
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
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公开(公告)号：US07678794B2
公开(公告)日：2010-03-16
申请号：US11718742
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： A61K31/50 , C07D209/54
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides a compound of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes for preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物：其药物组合物及其使用方法，其制备方法及其中间体。
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公开(公告)号：US20080139505A1
公开(公告)日：2008-06-12
申请号：US11718753
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
IPC分类号： A61K31/19 , C07D309/00 , A61K31/695 , A61K31/35 , C07C255/00 , A61K31/24 , C07D401/00 , C07D211/78 , C07D239/02 , C07D333/24 , A61K31/381 , A61K31/425 , C07D277/00 , A61K31/505 , C07D271/06 , A61K31/44 , C07C229/00 , A61K31/275 , A61K31/41 , C07D257/04 , C07C63/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物：其药物组合物及其使用方法，方法或制备方法及其中间体。
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公开(公告)号：US07803938B2
公开(公告)日：2010-09-28
申请号：US12549571
申请日：2009-08-28
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Micheal Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Micheal Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D239/32 , C07D271/113 , C07D291/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
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公开(公告)号：US07858646B2
公开(公告)日：2010-12-28
申请号：US11718446
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Dana Rae Benesh , Maria-Jesus Blanco-Pillado , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsäter , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Dana Rae Benesh , Maria-Jesus Blanco-Pillado , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsäter , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D401/04 , C07D213/79 , A61K31/41 , A61K31/4439
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物; 其药物组合物及其使用方法，方法或制备方法及其中间体。
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7.发明授权Pyridin-2yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus 有权吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物作为葡萄糖激酶活化剂用于治疗糖尿病公开(公告)号：US08853409B2
公开(公告)日：2014-10-07
申请号：US13493616
申请日：2012-06-11
申请人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
发明人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
IPC分类号： A61K31/44 , C07D417/00 , C07D417/14 , C07D417/12 , C07D213/75
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.
摘要翻译： 提供式（I）的化合物：其中R2，R3，R13，L和D2如说明书中所定义，其可用于治疗和/或预防由缺乏葡萄糖激酶水平的活性介导的疾病或病症，或可以 通过激活葡糖激酶，包括但不限于糖尿病，葡萄糖耐量降低，IFG（空腹血糖受损）和IFG（空腹血糖受损））以及其它疾病和病症如本文讨论的疾病和病症。
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公开(公告)号：US08431713B2
公开(公告)日：2013-04-30
申请号：US12524327
申请日：2008-01-16
申请人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Rustam Ferdinand Garrey , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner
发明人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Rustam Ferdinand Garrey , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner
IPC分类号： A61K31/44 , C07D213/55
CPC分类号： C07D495/04 , C07D417/14
摘要： Provided are compounds having the Formula I or salts thereof, wherein R2, L, R3, R11, D2 and R13 are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译： 提供具有式I的化合物或其盐，其中R2，L，R3，R11，D2和R13如本文所定义，其可用于治疗和/或预防由缺乏葡萄糖激酶水平的活性介导的疾病，例如 糖尿病 还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。
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9.发明授权Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 有权联苯酰胺内酰胺衍生物作为11-β-羟基类固醇脱氢酶的抑制剂1公开(公告)号：US08088776B2
公开(公告)日：2012-01-03
申请号：US12297349
申请日：2007-04-19
申请人： Thomas Daniel Aicher , Zhaogen Chen , Ronald Jay Hinklin , Gary Alan Hite , Alexei Pavlovych Krasutsky , Renhua Li , Jefferson Ray McCowan , Ashraf Saeed , Nancy June Snyder , James Lee Toth , Owen Brendan Wallace , Leonard Larry Winneroski, Jr. , Yanping Xu , Jeremy Schulenburg York
发明人： Thomas Daniel Aicher , Zhaogen Chen , Ronald Jay Hinklin , Gary Alan Hite , Alexei Pavlovych Krasutsky , Renhua Li , Jefferson Ray McCowan , Ashraf Saeed , Nancy June Snyder , James Lee Toth , Owen Brendan Wallace , Leonard Larry Winneroski, Jr. , Yanping Xu , Jeremy Schulenburg York
IPC分类号： A61K31/496 , A61K31/453 , C07D403/02 , C07D405/14
CPC分类号： C07D207/12 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention discloses novel compounds of Formula I: possessing 11 β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 β-HSD type 1 activity.
摘要翻译： 本发明公开了具有11＆amp; b -HSD 1型拮抗剂活性的式I化合物，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物，以及使用化合物和组合物治疗糖尿病，高血糖症，肥胖症，高血压，高脂血症，代谢综合征，认知障碍以及与其相关的其它病症的方法 ; -HSD 1型活动。
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公开(公告)号：US20100105659A1
公开(公告)日：2010-04-29
申请号：US12532374
申请日：2008-03-19
申请人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Ronald Jay Hinklin , Ajay Singh
发明人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Ronald Jay Hinklin , Ajay Singh
IPC分类号： A61K31/55 , C07D403/14 , A61K31/4545 , C07D495/02 , A61K31/4365 , C07D471/02 , A61K31/4355 , C07D239/02 , A61K31/506 , A61K31/519 , C07D215/16 , A61K31/47 , C07D401/02 , A61K31/439 , C07D401/14 , A61P3/00
CPC分类号： C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04
摘要： Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译： 提供了可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病的化合物。 还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。
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