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公开(公告)号：US09169325B2
公开(公告)日：2015-10-27
申请号：US13086286
申请日：2011-04-13
申请人： Tibor Keler , Henry C. Marsh , Lizhen He , Laura A. Vitale , Lawrence J. Thomas
发明人： Tibor Keler , Henry C. Marsh , Lizhen He , Laura A. Vitale , Lawrence J. Thomas
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/75 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人CD27和相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了使用抗体的治疗和诊断方法。
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2.发明授权Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) 有权结合人树突状细胞和上皮细胞205（DEC-205）的抗体公开(公告)号：US08236318B2
公开(公告)日：2012-08-07
申请号：US12266745
申请日：2008-11-07
申请人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
发明人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人DEC-205和相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US08586720B2
公开(公告)日：2013-11-19
申请号：US13542909
申请日：2012-07-06
申请人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
发明人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
IPC分类号： C07H21/04
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
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4.发明授权Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) 有权结合人树突状细胞和上皮细胞205（DEC-205）的抗体公开(公告)号：US08362214B2
公开(公告)日：2013-01-29
申请号：US12387654
申请日：2009-05-05
申请人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
发明人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人DEC-205和相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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5.发明授权Antibodies against human melanoma-associated chondroitin sulphate proteoglycan (MCSP) 失效针对人黑素瘤相关硫酸软骨素蛋白多糖（MCSP）的抗体公开(公告)号：US08318165B2
公开(公告)日：2012-11-27
申请号：US12439912
申请日：2007-09-10
申请人： Tibor Keler , Laura A. Vitale , Lizhen He
发明人： Tibor Keler , Laura A. Vitale , Lizhen He
IPC分类号： A61K39/395
CPC分类号： C07K16/3053 , A61K47/646 , C07K2317/732 , C12N5/0693 , C12N2501/90
摘要： The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided.
摘要翻译： 本发明提供了与人黑素瘤相关的硫酸软骨素蛋白聚糖（MCSP）的膜近端结构域（MP）结合的分离的抗体（例如，人源化或人抗体），并且能够介导表达MCSP的细胞的细胞溶解 存在人效应细胞或补体。 还提供了使用这种抗体诱导表达MP-MCSP的细胞的细胞溶解（例如ADCC或CDCC）的方法。
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6.发明申请ANTIBODIES AGAINST HUMAN MELANOMA-ASSOCIATED CHONDROITIN SULPHATE PROTEOGLYCAN (MCSP) 失效针对人类与人类血红蛋白相关的磺酸锌抗体（MCSP）的抗体公开(公告)号：US20100303816A1
公开(公告)日：2010-12-02
申请号：US12439912
申请日：2007-09-10
申请人： Tibor Keler , Laura A. Vitale , Lizhen He
发明人： Tibor Keler , Laura A. Vitale , Lizhen He
CPC分类号： C07K16/3053 , A61K47/646 , C07K2317/732 , C12N5/0693 , C12N2501/90
摘要： The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided.
摘要翻译： 本发明提供了与人黑素瘤相关的硫酸软骨素蛋白聚糖（MCSP）的膜近端结构域（MP）结合的分离的抗体（例如，人源化或人抗体），并且能够介导表达MCSP的细胞的细胞溶解 存在人效应细胞或补体。 还提供了使用这种抗体诱导表达MP-MCSP的细胞的细胞溶解（例如ADCC或CDCC）的方法。
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7.发明申请Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) 有权结合人树突状细胞和上皮细胞205（DEC-205）的抗体公开(公告)号：US20100098704A1
公开(公告)日：2010-04-22
申请号：US12387654
申请日：2009-05-05
申请人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
发明人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
IPC分类号： A61K39/395 , C07K16/28 , C12N15/63 , C07K19/00
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人DEC-205和相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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8.发明授权公开(公告)号：US07456264B2
公开(公告)日：2008-11-25
申请号：US10850635
申请日：2004-05-21
申请人： Tibor Keler , Israel Lowy , Laura A. Vitale , Diann Blanset , Mohan Srinivasan
发明人： Tibor Keler , Israel Lowy , Laura A. Vitale , Diann Blanset , Mohan Srinivasan
IPC分类号： C07K16/12 , A61K39/40 , G01N33/569
CPC分类号： C07K16/1278 , A61K47/6835 , A61K51/1009 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与炭疽保护性抗原结合的分离的人单克隆抗体。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的非人转基因动物，例如转基因小鼠中产生。 还公开了人抗体（例如双特异性抗体和免疫偶联物）的衍生物，包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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9.发明授权公开(公告)号：US08404820B2
公开(公告)日：2013-03-26
申请号：US12247032
申请日：2008-10-07
申请人： Tibor Keler , Israel Lowy , Laura A. Vitale , Diann Blanset , Mohan Srinivasan
发明人： Tibor Keler , Israel Lowy , Laura A. Vitale , Diann Blanset , Mohan Srinivasan
IPC分类号： C07K16/12 , A61K39/40 , G01N33/569
CPC分类号： C07K16/1278 , A61K47/6835 , A61K51/1009 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与炭疽保护性抗原结合的分离的人单克隆抗体。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的非人转基因动物，例如转基因小鼠中产生。 还公开了人抗体（例如双特异性抗体和免疫偶联物）的衍生物，包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20050180983A1
公开(公告)日：2005-08-18
申请号：US10903191
申请日：2004-07-30
申请人： Tibor Keler , Michael Endres , Lizhen He , Venky Ramakrishna
发明人： Tibor Keler , Michael Endres , Lizhen He , Venky Ramakrishna
IPC分类号： A61K39/00 , C07K14/59 , C07K16/28 , A61K39/395 , C07K16/46
CPC分类号： C07K16/2851 , A61K39/0006 , A61K39/0011 , A61K2039/5154 , A61K2039/572 , A61K2039/6056 , C07K14/59 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2318/10 , C07K2319/00 , C07K2319/33 , Y02A50/401 , Y02A50/412 , Y02A50/469
摘要： The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody.
摘要翻译： 本发明提供新的抗体疫苗缀合物及其使用方法诱导细胞毒性T细胞（CTL）应答。 在具体的实施方案中，疫苗缀合物包括与抗甘露糖受体（MR）抗体连接的人绒毛膜促性腺激素β亚基（betahCG）抗原。
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