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    Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
    1.
    发明申请
    Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility 失效
    用于控制活性剂释放或血液相容性的装置，制品，涂层和方法

    公开(公告)号：US20070026037A1

    公开(公告)日：2007-02-01

    申请号：US11493346

    申请日：2006-07-26

    申请人： Timothy Kloke ,  Robert Hergenrother ,  Laurie Lawin

    发明人： Timothy Kloke ,  Robert Hergenrother ,  Laurie Lawin

    IPC分类号： A61F2/06 ,  A61K31/785

    CPC分类号： C09D133/14 ,  A61K31/785 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/80 ,  C08L33/26

    摘要： The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

    摘要翻译： 本发明涉及用于控制的活性剂释放和/或用于提供血液相容性表面的装置，制品，涂层和方法。 更具体地说，本发明涉及与受控活性剂释放相同的共聚物组合物和装置，制品和方法。 在一个实施方案中，本发明包括共聚物组合物。 共聚物组合物可以包括共聚物和活性剂。 在一个实施方案中，共聚物包括包含极性部分的单体单元的有效部分。 活性剂可以是极性的。 活性剂可以充电。 活性剂可以是非极性的。 在一个实施方案中，共聚物组合物包括无规共聚物。 在一个实施方案中，无规共聚物包括可提供降低的血小板粘附的甲基丙烯酸丁酯 - 共 - 丙烯酰氨基 - 甲基 - 丙烷磺酸共聚物。

    BARRIERS FOR POLYMERIC COATINGS
    2.
    发明申请
    BARRIERS FOR POLYMERIC COATINGS 审中-公开
    聚合物涂层遮蔽物

    公开(公告)号：US20080031918A1

    公开(公告)日：2008-02-07

    申请号：US11873747

    申请日：2007-10-17

    申请人： Laurie Lawin ,  Michelle Boucha-Rayle ,  Timothy Kloke

    发明人： Laurie Lawin ,  Michelle Boucha-Rayle ,  Timothy Kloke

    IPC分类号： A61F2/82 ,  A61K31/745 ,  A61P9/00

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606

    摘要： A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical device, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protection to the polymeric composition from mechanical damage and/or delamination during fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandable balloon, between which is positioned a barrier of the type described.

    摘要翻译： 适于定位在在医疗装置上以聚合物，含生物活性剂的涂层形式提供的第一表面和由第一表面相对位置并且优选地可移动地配置的另一材料提供的第二表面之间的屏障。 通过嵌段共聚物或光衍生化聚合物提供的屏障为聚合物组合物在制造，储存，递送或展开期间的机械损伤和/或分层提供了保护，并且/或在体内停留该装置。 包括诸如支架的医疗装置和诸如周围护套或内部可膨胀气囊的另一装置的组合，其间定位有所述类型的屏障。

    Controlled release bioactive agent delivery device
    5.
    发明申请
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US20050287188A1

    公开(公告)日：2005-12-29

    申请号：US11203981

    申请日：2005-08-15

    申请人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    发明人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.

    摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

    Controlled release bioactive agent delivery device
    6.
    发明申请
    Controlled release bioactive agent delivery device 审中-公开
    控制释放生物活性剂输送装置

    公开(公告)号：US20050271706A1

    公开(公告)日：2005-12-08

    申请号：US11204271

    申请日：2005-08-15

    申请人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene Juan ,  Signe Varner ,  Ralph Chappa

    发明人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene Juan ,  Signe Varner ,  Ralph Chappa

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.

    摘要翻译： 本发明提供了将生物活性剂递送到眼睛的方法，所述方法包括以下步骤：在眼睛内的植入部位提供装置，并将装置保持在植入部位以向眼睛提供治疗有效量的生物活性剂。 该装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中主体构件的至少一部分偏离延伸方向。 提供与主体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了将治疗有效量的生物活性剂施用于眼后段的方法。

    Biodegradable controlled release bioactive agent delivery device
    8.
    发明申请
    Biodegradable controlled release bioactive agent delivery device 审中-公开
    可生物降解的控释生物活性剂输送装置

    公开(公告)号：US20060034891A1

    公开(公告)日：2006-02-16

    申请号：US11175910

    申请日：2005-07-05

    申请人： Laurie Lawin ,  Aron Anderson

    发明人： Laurie Lawin ,  Aron Anderson

    IPC分类号： A61F2/00

    CPC分类号： A61F9/0017 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61K9/0051

    摘要： The invention provides implantable medical devices that are fabricated, at least in part, from biodegradable polymeric material. The implantable medical devices are used to provide bioactive agent to a treatment site, and are particularly useful for treatment of limited access regions of the body.

    摘要翻译： 本发明提供了至少部分地由可生物降解的聚合材料制造的可植入医疗装置。 可植入医疗装置用于向治疗部位提供生物活性剂，并且对于治疗身体的有限进入区域特别有用。

    Controlled release bioactive agent delivery device
    9.
    发明申请
    Controlled release bioactive agent delivery device 审中-公开
    控制释放生物活性剂输送装置

    公开(公告)号：US20050281863A1

    公开(公告)日：2005-12-22

    申请号：US11203931

    申请日：2005-08-15

    申请人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    发明人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.

    摘要翻译： 本发明提供控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物和所述第二聚合物是疏水性的。 本发明还提供了以受控释放方式将生物活性剂递送至患者的方法，以及制备控制释放的生物活性剂递送装置的方法。