公开(公告)号：US20070026037A1

公开(公告)日：2007-02-01

申请号：US11493346

申请日：2006-07-26

申请人： Timothy Kloke ,  Robert Hergenrother ,  Laurie Lawin

发明人： Timothy Kloke ,  Robert Hergenrother ,  Laurie Lawin

IPC分类号： A61F2/06 ,  A61K31/785

CPC分类号： C09D133/14 ,  A61K31/785 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/80 ,  C08L33/26

摘要： The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

摘要翻译： 本发明涉及用于控制的活性剂释放和/或用于提供血液相容性表面的装置，制品，涂层和方法。 更具体地说，本发明涉及与受控活性剂释放相同的共聚物组合物和装置，制品和方法。 在一个实施方案中，本发明包括共聚物组合物。 共聚物组合物可以包括共聚物和活性剂。 在一个实施方案中，共聚物包括包含极性部分的单体单元的有效部分。 活性剂可以是极性的。 活性剂可以充电。 活性剂可以是非极性的。 在一个实施方案中，共聚物组合物包括无规共聚物。 在一个实施方案中，无规共聚物包括可提供降低的血小板粘附的甲基丙烯酸丁酯 - 共 - 丙烯酰氨基 - 甲基 - 丙烷磺酸共聚物。

公开(公告)号：US20080031918A1

公开(公告)日：2008-02-07

申请号：US11873747

申请日：2007-10-17

申请人： Laurie Lawin ,  Michelle Boucha-Rayle ,  Timothy Kloke

发明人： Laurie Lawin ,  Michelle Boucha-Rayle ,  Timothy Kloke

IPC分类号： A61F2/82 ,  A61K31/745 ,  A61P9/00

CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606

摘要： A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical device, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protection to the polymeric composition from mechanical damage and/or delamination during fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandable balloon, between which is positioned a barrier of the type described.

摘要翻译： 适于定位在在医疗装置上以聚合物，含生物活性剂的涂层形式提供的第一表面和由第一表面相对位置并且优选地可移动地配置的另一材料提供的第二表面之间的屏障。 通过嵌段共聚物或光衍生化聚合物提供的屏障为聚合物组合物在制造，储存，递送或展开期间的机械损伤和/或分层提供了保护，并且/或在体内停留该装置。 包括诸如支架的医疗装置和诸如周围护套或内部可膨胀气囊的另一装置的组合，其间定位有所述类型的屏障。

公开(公告)号：US20050260246A1

公开(公告)日：2005-11-24

申请号：US11123835

申请日：2005-05-06

申请人： Stephen Chudzik ,  Aron Anderson ,  Ralph Chappa ,  Timothy Kloke ,  Laurie Lawin ,  Klaus Wormuth

发明人： Stephen Chudzik ,  Aron Anderson ,  Ralph Chappa ,  Timothy Kloke ,  Laurie Lawin ,  Klaus Wormuth

IPC分类号： A61F2/02 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/606 ,  C08L33/06

摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

摘要翻译： 用于涂覆可植入医疗装置以提高其在体内释放生物活性剂的能力的涂料组合物。 涂料组合物特别适用于在其输送和/或使用过程（例如支架和导管）中经历显着弯曲和/或膨胀的装置。 组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。

公开(公告)号：US20060067968A1

公开(公告)日：2006-03-30

申请号：US11281845

申请日：2005-11-17

申请人： Stephen Chudzik ,  Aron Anderson ,  Ralph Chappa ,  Timothy Kloke

发明人： Stephen Chudzik ,  Aron Anderson ,  Ralph Chappa ,  Timothy Kloke

IPC分类号： A61F13/00 ,  B05D3/00

CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606 ,  C08L33/06

摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

公开(公告)号：US20070027452A1

公开(公告)日：2007-02-01

申请号：US11436277

申请日：2006-05-18

申请人： Signe Varner ,  Matthew McCormick ,  Aaron Barnes ,  Timothy Kloke ,  Nathan Fox Beeley ,  Doug Patton

发明人： Signe Varner ,  Matthew McCormick ,  Aaron Barnes ,  Timothy Kloke ,  Nathan Fox Beeley ,  Doug Patton

IPC分类号： A61F9/00

CPC分类号： A61F9/0017 ,  A61F2/88 ,  A61F9/007

摘要： The invention provides an insertion instrument and methods for rotatably inserting an insertable medical device into a target region of the body. In particular, the instrument can be used in a method for rotatably inserting a medical device having a helical shape into a portion of the eye. The instrument includes a distal portion with a securing member that can hold a portion of the device during the rotational insertion process, and an actuating member that can be triggered to gently release the device upon insertion of the device into the target site.

摘要翻译： 本发明提供了一种用于将可插入医疗装置可旋转地插入到身体的目标区域中的插入器具和方法。 特别地，该仪器可以用于将具有螺旋形状的医疗装置可旋转地插入到眼睛的一部分中的方法中。 仪器包括具有固定构件的远侧部分，该固定构件可在旋转插入过程期间保持该装置的一部分，以及致动构件，其可以在将装置插入目标位置时被触发以轻轻地释放装置。