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公开(公告)号：US20100120859A1
公开(公告)日：2010-05-13
申请号：US12594905
申请日：2008-05-23
申请人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich L. Grimm , Sebastien Laliberte , Austin Chen
发明人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich L. Grimm , Sebastien Laliberte , Austin Chen
IPC分类号： A61K31/451 , A61K31/4545 , A61K31/454 , C07D401/04 , C07D401/12 , C07D211/60 , A61P25/00 , A61P9/00
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有羧酸酯或羧酸端基的哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US08343968B2
公开(公告)日：2013-01-01
申请号：US12594905
申请日：2008-05-23
申请人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich I. Grimm , Sebastien Laliberte , Austin Chen
发明人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich I. Grimm , Sebastien Laliberte , Austin Chen
IPC分类号： A61K31/535 , A61K31/445 , C07D413/12 , C07D211/60
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有羧酸酯或羧酸端基的哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US08076359B2
公开(公告)日：2011-12-13
申请号：US12312454
申请日：2007-11-14
申请人： Daniel Dube , Michel Gallant , Erich L. Grimm , Helene Juteau , Sebastien Laliberte , Tom Yao-Hsiang Wu
发明人： Daniel Dube , Michel Gallant , Erich L. Grimm , Helene Juteau , Sebastien Laliberte , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4545 , A61K31/451 , C07D211/60
CPC分类号： C07D211/60 , C07D401/04
摘要： The present invention relates to disubstituted piperidinyl renin inhibitor compounds having the structure (Formula I) and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有结构（式I）的二取代哌啶肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US20100063091A1
公开(公告)日：2010-03-11
申请号：US12312454
申请日：2007-11-14
申请人： Daniel Dube , Michel Gallant , Erich L. Grimm , Helene Juteau , Sebastien Laliberte , Tom Yao-Hsiang Wu
发明人： Daniel Dube , Michel Gallant , Erich L. Grimm , Helene Juteau , Sebastien Laliberte , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4545 , C07D211/68 , C07D211/30 , A61K31/445 , A61P9/10
CPC分类号： C07D211/60 , C07D401/04
摘要： The present invention relates to disubstituted piperidinyl renin inhibitor compounds having the structure (Formula I) and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有结构（式I）的二取代哌啶肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US08334308B2
公开(公告)日：2012-12-18
申请号：US12674040
申请日：2008-08-18
申请人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
发明人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
IPC分类号： A01N43/40 , A01N37/34 , A01N37/12 , A01N33/02 , A61K31/44 , A61K31/275 , C07D213/78 , C07D213/24 , C07C211/00
CPC分类号： C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要： The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有氨基末端基团的联苯基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US20110263658A1
公开(公告)日：2011-10-27
申请号：US12674040
申请日：2008-08-18
申请人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
发明人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4412 , A61K31/135 , C07C229/34 , A61K31/216 , C07D213/38 , A61K31/4418 , C07C255/43 , A61K31/277 , C07C271/12 , A61K31/27 , C07C237/20 , A61K31/165 , C07D211/76 , A61P9/12 , A61P13/12 , A61P9/00 , A61P3/10 , A61P27/06 , A61P15/10 , A61P25/22 , A61P25/28 , C07C211/01
CPC分类号： C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要： The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有氨基末端基团的联苯基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US20110237622A1
公开(公告)日：2011-09-29
申请号：US13139012
申请日：2009-12-08
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce Mackay , Daniel James Mckay , Tom Yao-Hsiang Wu
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce Mackay , Daniel James Mckay , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4545 , C07D401/04 , A61P9/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P11/00 , A61P25/22 , A61P25/00 , A61P15/10 , A61P27/06
CPC分类号： C07D401/04
摘要： The present invention relates to 3,4-substituted piperidinyl—based renin inhibitor compounds bearing at 4-position oxopyridine or Isoquinolone and having the formula (I): wherein S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位氧代吡啶或异喹啉酮上具有式（I）的3,4-取代哌啶基肾素抑制剂化合物：其中S为式（IIa）或式（IIb）。 本发明还涉及含有所述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US08889714B2
公开(公告)日：2014-11-18
申请号：US12990927
申请日：2009-05-04
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号： A61K31/4545 , C07D401/14 , C07D417/14 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04 , C07D417/14
摘要： The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位氧代吡啶上具有式（I）的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US20110053940A1
公开(公告)日：2011-03-03
申请号：US12990927
申请日：2009-05-04
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号： A61K31/4545 , C07D401/04 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/4709 , A61K31/4725 , A61P9/12 , A61P9/00 , A61P27/02 , A61P25/00 , A61P11/00 , A61P9/10 , A61P13/12
CPC分类号： C07D401/14 , C07D401/04 , C07D417/14
摘要： The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位氧代吡啶上具有式（I）的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US20110152316A1
公开(公告)日：2011-06-23
申请号：US12993127
申请日：2009-05-21
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4709 , C07D401/04 , A61P9/12 , A61P9/00 , A61P11/00 , A61P13/12 , A61P27/06 , A61P15/10 , A61P25/22
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position Isoqumolone and having the Formula (I): The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位异亮霉素下具有式（I）的3,4-取代哌啶基肾素抑制剂化合物：本发明还涉及含有所述化合物的药物组合物及其在治疗心血管事件中的用途 和肾功能不全。
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