公开(公告)号：US20100069433A1

公开(公告)日：2010-03-18

申请号：US12593356

申请日：2008-03-28

申请人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

发明人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

IPC分类号： A61K31/47 ,  A61K31/42

CPC分类号： C07D263/58 ,  A61K31/423 ,  A61K31/47

摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.

摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖症或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由下式表示的化合物 （1）表示：其中：R 1和R 2可以相同或不同，各自表示氢原子，甲基或乙基; R3a，R3b，R4a和R4b可以相同或不同，分别表示氢原子，卤素原子，硝基，羟基，C1-4烷基，三氟甲基，C1-4烷氧基 ，C 1-4烷基羰基氧基，二-C 1-4烷基氨基，C 1-4烷基磺酰氧基，C 1-4烷基磺酰基，C 1-4烷基亚磺酰基或C 1-4烷硫基，或R 3a和R 3b ，或R4a和R4b连接以代表亚烷基二氧基; X表示氧原子，硫原子或N-R5（其中，R5表示氢原子，C1-4烷基，C1-4烷基磺酰基或C1-4烷氧基羰基）。 Y表示氧原子，S（O）1基（l表示0〜2的数），羰基，羰基氨基，氨基羰基，磺酰基氨基，氨基磺酰基或NH基。 Z表示CH或N; n表示1〜6的数; m代表2至6的数，或其盐，他汀类，特别是匹伐他汀组合。

公开(公告)号：US08426455B2

公开(公告)日：2013-04-23

申请号：US12593356

申请日：2008-03-28

申请人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

发明人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

IPC分类号： A61K31/42

CPC分类号： C07D263/58 ,  A61K31/423 ,  A61K31/47

摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the formula (1), or a salt thereof, and a statin, particularly pitavastatin, in combination.

摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由式（ 1）或其盐，他汀类，特别是匹伐他汀组合。

公开(公告)号：US20130102621A1

公开(公告)日：2013-04-25

申请号：US13806940

申请日：2011-06-24

申请人： Toshiharu Morimoto ,  Tomoaki Koshizawa ,  Gen Watanabe ,  Tadaaki Ohgiya ,  Nao Yamasaki ,  Noriyuki Inoue

发明人： Toshiharu Morimoto ,  Tomoaki Koshizawa ,  Gen Watanabe ,  Tadaaki Ohgiya ,  Nao Yamasaki ,  Noriyuki Inoue

IPC分类号： C07D491/048 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D491/048 ,  C07D487/04 ,  C07D495/04

摘要： The present invention relates to provision of a novel compound that has an activity of promoting insulin secretion from pancreatic β cells and thus is useful as a prophylaxis and/or therapeutic agent for diseases caused by hyperglycemia such as diabetes mellitus, andthe compound represented by the following formula (1): wherein one of A and B represents a nitrogen atom and the other represents a nitrogen atom or CR10, X represents an oxygen atom, a sulfur atom or —(CH2)n-N(R12)—, Y represents an oxygen atom, a sulfur atom or —N(R13)—, and R1 to R9 each represent a hydrogen atom or another substituent, or a salt thereof, or a solvate of the compound or the salt.

摘要翻译： 本发明涉及提供具有促进胰β细胞胰岛素分泌的活性的新型化合物，因此可用作由高血糖引起的疾病如糖尿病的预防和/或治疗剂，以及由 下式（1）：其中A和B之一表示氮原子，另一个表示氮原子或CR 10，X表示氧原子，硫原子或 - （CH 2）n N（R 12） - ，Y表示氧 原子，硫原子或-N（R 13） - ，并且R 1至R 9各自表示氢原子或其它取代基，或其盐，或化合物或其盐的溶剂合物。

公开(公告)号：US07990093B2

公开(公告)日：2011-08-02

申请号：US12279859

申请日：2006-04-20

申请人： Isao Kezobo ,  Masahiro Kimata ,  Takayuki Kifuku ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Noriyuki Inoue

发明人： Isao Kezobo ,  Masahiro Kimata ,  Takayuki Kifuku ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Noriyuki Inoue

IPC分类号： H02P7/00

CPC分类号： B62D5/0487 ,  B62D5/0484 ,  H02P21/00 ,  H02P29/032

摘要： A control apparatus for a multiphase AC electric motor having an inverter includes a current control including an abnormal-state current controller; an abnormal-state detector that detects an abnormal state of any of a wire of an electric motor, a wire of an inverter, and a wire connecting the electric motor to the inverter as an abnormal phase; and an abnormal phase disconnect. The abnormal phase disconnect disconnects one or more of phases detected to be in an abnormal-state and the abnormal-state current controller generates an abnormal state voltage command in accordance with detection of an abnormal state, and uses phases other than the disconnected phases of the inverter to control individual currents of the phases, with the abnormal-state voltage command used as a multiphase voltage command.

摘要翻译： 一种具有逆变器的多相交流电动机的控制装置包括：电流控制装置，包括异常电流控制器; 异常状态检测器，其检测电动机的线材，逆变器的线以及将电动机与逆变器连接的线的异常状态，作为异常相位; 和异常相断开。 异常相位断开断开检测到异常状态的一个或多个相位，异常状态电流控制器根据异常状态的检测产生异常状态电压指令，并且使用除 逆变器用于控制各相电流，异常状态电压指令用作多相电压指令。

公开(公告)号：US20090128990A1

公开(公告)日：2009-05-21

申请号：US12355706

申请日：2009-01-16

申请人： Noriyuki Inoue ,  Toshihiro Okamatsu

发明人： Noriyuki Inoue ,  Toshihiro Okamatsu

IPC分类号： C04B35/468 ,  H01G4/12

CPC分类号： H01B3/12 ,  C01G23/006 ,  C01G53/006 ,  C01G53/70 ,  C01P2002/54 ,  C01P2002/72 ,  C01P2004/62 ,  C01P2006/40 ,  C04B35/4682 ,  C04B35/6261 ,  C04B35/62685 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3229 ,  C04B2235/3232 ,  C04B2235/3234 ,  C04B2235/3236 ,  C04B2235/3262 ,  C04B2235/3268 ,  C04B2235/3279 ,  C04B2235/3281 ,  C04B2235/3282 ,  C04B2235/3418 ,  C04B2235/5445 ,  C04B2235/6025 ,  C04B2235/652 ,  C04B2235/6582 ,  C04B2235/6584 ,  C04B2235/6588 ,  C04B2235/79 ,  C04B2235/80 ,  C04B2235/85 ,  H01G4/1227 ,  H01G4/30

摘要： A dielectric ceramic contains a barium titanate compound oxide as a main component; at least one rare earth element R selected from Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu; Mg; and Ni, such that a crystalline compound oxide containing the rare earth element R, Ni, and Ti as main components is present. Dielectric ceramic layers are made of the dielectric ceramic. Accordingly, even when a higher electric field is continuously applied under a high-temperature atmosphere for a long time, high reliability can be ensured.

摘要翻译： 介电陶瓷含有钛酸钡复合氧化物作为主要成分; 选自Y，La，Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb和Lu中的至少一种稀土元素R; 镁 和Ni，使得含有稀土元素R，Ni和Ti作为主要成分的结晶复合氧化物存在。 介电陶瓷层由电介质陶瓷制成。 因此，即使长时间在高温环境下连续施加较高的电场，也可以确保高可靠性。

公开(公告)号：US20070176577A1

公开(公告)日：2007-08-02

申请号：US10590931

申请日：2005-03-16

申请人： Isao Kezobo ,  Masahiro Kimata ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Kouji Fukusumi ,  Noriyuki Inoue

发明人： Isao Kezobo ,  Masahiro Kimata ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Kouji Fukusumi ,  Noriyuki Inoue

IPC分类号： H02P27/04

CPC分类号： B62D5/0487 ,  B62D5/046 ,  B62D5/0484 ,  H02P29/032

摘要： A control apparatus for an electric motor, in which a current controller giving multiphase voltage commands to a drive circuit for an inverter includes a normal-mode current controller for use in a normal mode, an abnormal-mode current controller for use in an abnormal mode, and an abnormality decision device. In a case of an abnormality occurring to one phase of an electric motor or the inverter, the controller is altered, and the abnormal-mode multiphase voltage commands which are generated by the abnormal-mode current controller are set as the multiphase voltage commands for the inverter drive circuit.

摘要翻译： 一种用于电动机的控制装置，其中向逆变器的驱动电路提供多相电压指令的电流控制器包括用于正常模式的正常模式电流控制器，用于异常模式的异常模式电流控制器 ，以及异常判定装置。 在电动机或逆变器的一相发生异常的情况下，改变控制器，将异常电流控制器产生的异常多相电压指令设定为多相电压指令 变频器驱动电路。

公开(公告)号：US20070009719A1

公开(公告)日：2007-01-11

申请号：US11517515

申请日：2006-09-08

申请人： Masahiro Naito ,  Noriyuki Inoue

发明人： Masahiro Naito ,  Noriyuki Inoue

IPC分类号： C04B35/48 ,  B32B18/00

CPC分类号： H01G4/1236 ,  C04B35/486 ,  C04B35/49 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3217 ,  C04B2235/3232 ,  C04B2235/3281 ,  C04B2235/3409 ,  C04B2235/3418 ,  C04B2235/6025 ,  C04B2235/656 ,  C04B2235/6584 ,  C04B2235/664 ,  C04B2235/768 ,  C04B2235/785 ,  C04B2235/80 ,  Y10T29/435 ,  Y10T428/24926

摘要： A ceramic base body includes primary phase particles containing a CaZrO3-based compound as a primary component and secondary phase particles containing at least Mn, and internal electrodes are primarily composed of Cu. There are about 2 parts by mole or more of Mn and about 0.69 parts by mole or more of Si pph by mole of primary component, are contained in the ceramic base body, and the area ratio of the secondary phase particles on a cross-section of the ceramic base body is about 0.1% or more. Of those secondary phase particles having a particle diameter of about 0.1 μm or more, about 67% or more (preferably about 85% or more) contains Cu and Si. A multilayer ceramic capacitor containing the ceramic base body can be manufactured by performing a heat treatment at a temperature of about 700° C. or more in a reducing atmosphere at an oxygen partial pressure of about 10−8.5 MPa or less after the formation of external electrodes. As a result, a highly reliable multilayer ceramic capacitor can be realized in which the temperature properties of electrostatic capacitance are superior, a high Q value is obtained, and the degradation in high-temperature load lifetime can be suppressed.

摘要翻译： 陶瓷基体包括含有基于CaZrO 3/3的化合物作为主要组分的初级相颗粒和至少含有Mn的第二相颗粒，内部电极主要由Cu组成。 在陶瓷基体中含有约2份摩尔以上的Mn和约0.69份摩尔的主成分的Si pph，并且第二相颗粒在横截面上的面积比 的陶瓷基体为约0.1％以上。 在具有约0.1μm以上，约67％以上（优选约85％以上）的粒径的二次相颗粒中含有Cu和Si。 含有陶瓷基体的多层陶瓷电容器可以通过在还原性气氛中在大约10 -8 -5℃的氧分压下在约700℃以上的温度下进行热处理来制造 或更少的外部电极形成。 结果，可以实现高度可靠的多层陶瓷电容器，其中静电电容的温度特性优异，获得高Q值，并且可以抑制高温负载寿命的劣化。

公开(公告)号：US06983818B2

公开(公告)日：2006-01-10

申请号：US11053922

申请日：2005-02-10

申请人： Takehiko Fujioka ,  Theerawat Limpibunterng ,  Hajime Oyama ,  Noriyuki Inoue ,  Masaya Endo

发明人： Takehiko Fujioka ,  Theerawat Limpibunterng ,  Hajime Oyama ,  Noriyuki Inoue ,  Masaya Endo

IPC分类号： B62D5/04

CPC分类号： B62D5/006 ,  B62D6/008

摘要： In the control of an electric power steering apparatus, where so-called lead steering control is performed in which a steering wheel angle signal is output through a lead filter to correct reaction delay of a driver and a vehicle, a delay in control response occurs due to feedback of a road surface reaction force torque. When road surface reaction force torque is fed back to the steering wheel, it is added through a low-pass filter having a time constant equal to a reaction delay time constant of a driver. A sum signal is output through a lead filter to a second motor for controlling a steering shaft.

摘要翻译： 在进行所谓的牵引转向控制的电动助力转向装置的控制中，其中通过引导过滤器输出方向盘角度信号以校正驾驶员和车辆的反应延迟，由此产生控制响应延迟 反馈路面反作用力矩。 当路面反作用力扭矩反馈到方向盘时，通过具有等于驾驶员的反应延迟时间常数的时间常数的低通滤波器来添加。 和信号通过引线过滤器输出到用于控制转向轴的第二电动机。

公开(公告)号：US06938725B2

公开(公告)日：2005-09-06

申请号：US10796285

申请日：2004-03-10

申请人： Takehiko Fujioka ,  Theerawat Limpibunterng ,  Hajime Oyama ,  Noriyuki Inoue ,  Masaya Endo

发明人： Takehiko Fujioka ,  Theerawat Limpibunterng ,  Hajime Oyama ,  Noriyuki Inoue ,  Masaya Endo

IPC分类号： B62D5/00 ,  B62D5/04 ,  B62D6/00 ,  B62D111/00 ,  B62D113/00 ,  B62D119/00

CPC分类号： B62D5/006 ,  B62D6/008

摘要： In the control of an electric power steering apparatus, where so-called lead steering control is performed in which a steering wheel angle signal is output through a lead filter to correct reaction delay of a driver and a vehicle, a delay in control response occurs due to feedback of a road surface reaction force torque. When road surface reaction force torque is fed back to the steering wheel, it is added through a low-pass filter having a time constant equal to a reaction delay time constant of a driver. A sum signal is output through a lead filter to a second motor for controlling a steering shaft.

摘要翻译： 在进行所谓的牵引转向控制的电动助力转向装置的控制中，其中通过引导过滤器输出方向盘角度信号以校正驾驶员和车辆的反应延迟，由此产生控制响应延迟 反馈路面反作用力矩。 当路面反作用力扭矩反馈到方向盘时，通过具有等于驾驶员的反应延迟时间常数的时间常数的低通滤波器来添加。 和信号通过引线过滤器输出到用于控制转向轴的第二电动机。

公开(公告)号：US20050072622A1

公开(公告)日：2005-04-07

申请号：US10754709

申请日：2004-01-12

申请人： Toshihide Satake ,  Masahiko Kurishige ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Noriyuki Inoue

发明人： Toshihide Satake ,  Masahiko Kurishige ,  Kazumichi Tsutsumi ,  Chiaki Fujimoto ,  Noriyuki Inoue

IPC分类号： B62D6/00 ,  B62D5/04 ,  B62D101/00 ,  B62D113/00 ,  B62D117/00 ,  B62D119/00

CPC分类号： B62D5/0484

摘要： A motor-driven power steering control apparatus assuring consistently comfortable steering operation of a motor vehicle includes a steering state detecting means (10), a motor drive command value arithmetic means (20), a trouble detecting means (40), a motor drive command value correcting means (51, 52) for decrementing a motor drive command value outputted from the motor drive command value correcting means (51) from a predetermined initial value as a function of time lapse when a trouble detection signal is outputted from the trouble detecting means (40), and a means (30) for driving an assist motor in conformance with the output of the motor drive command value correcting means (51, 52). The motor drive command value correcting means (51, 52) includes a low-pass filter (515) for smoothing the motor drive command value. A value acquired through the low-pass filter (515) is employed as the predetermined initial value.

摘要翻译： 确保机动车辆一贯舒适的转向操作的马达驱动的动力转向控制装置包括转向状态检测装置（10），马达驱动指令值运算装置（20），故障检测装置（40），马达驱动指令 用于当从所述故障检测装置输出故障检测信号时，将从所述马达驱动指令值校正装置（51）输出的马达驱动指令值从作为时间流逝的函数的预定初始值递减的值校正装置（51,52） （40），以及用于根据电动机驱动指令值修正装置（51,52）的输出驱动辅助电动机的装置（30）。 马达驱动指令值修正装置（51,52）包括用于使马达驱动指令值平滑的低通滤波器（515）。 通过低通滤波器（515）获取的值被用作预定的初始值。