公开(公告)号：US11866685B2

公开(公告)日：2024-01-09

申请号：US16939685

申请日：2020-07-27

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Christopher Wu

IPC: C12M1/34 ,  C12M1/12 ,  C12M1/42 ,  C12M1/00 ,  C12M1/32 ,  C08L33/26 ,  C08L33/10

CPC classification number: C12M41/12 ,  C12M23/20 ,  C12M25/14 ,  C12M35/02 ,  C12M35/04 ,  C08L33/10 ,  C08L33/26 ,  C12M23/12

Abstract: Biocompatible, mechanically-dynamic thermoresponsive devices, methods for forming the devices, and exemplary applications for the devices are described. The devices include a series of wells therein and provide for temperature-controlled mechanostimulation of single cells or groups of cells that can be retained in the wells of a device. Mechanostimulation can be single instance of any duration, continuous, or regular or irregular cyclic mechanostimulation of single cells, cell clusters, cell spheroids, or organoids and may be utilized in any of a variety of biomedical applications including, without limitation, cellular engineering, cellular phenotyping, and drug discovery/screening.

公开(公告)号：US10463631B2

公开(公告)日：2019-11-05

申请号：US16004576

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghada

IPC: A61K31/047 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US20180353439A1

公开(公告)日：2018-12-13

申请号：US16004538

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Wesley F. Taylor

IPC: A61K31/047 ,  A61P35/00 ,  A61K45/06 ,  A61K31/7072

CPC classification number: A61K31/047 ,  A61K31/7072 ,  A61K45/06 ,  A61P35/00

Abstract: A pimarane diterpenoid, having the following structure: or a tautomer thereof in which R1 and R2 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O based on an isolate from the plant Hymenocrater elegans is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The compound shows efficacy in treatment and prevention of a wide range of cancer types as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.

公开(公告)号：US11426360B2

公开(公告)日：2022-08-30

申请号：US16578688

申请日：2019-09-23

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghadam

IPC: A61K31/047 ,  A61K31/05 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US11357739B2

公开(公告)日：2022-06-14

申请号：US16578673

申请日：2019-09-23

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghadam

IPC: A61K31/47 ,  A61K31/047 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment, as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US20180369165A1

公开(公告)日：2018-12-27

申请号：US16004550

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Wesley F. Taylor ,  Sara Eslambolchimoghada

IPC: A61K31/122 ,  A61P35/02

CPC classification number: A61K31/122 ,  A61K31/7072 ,  A61K2300/00 ,  A61P35/02

Abstract: A deacetylnemorone abietane diterpenoid is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The deacetylnemorone can have the following structure: or a tautomer there of in which R1, R2, and R3 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O.The deacetylnemorone shows efficacy in treatment and prevention of a wide range of cancer types as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.

公开(公告)号：US11698344B2

公开(公告)日：2023-07-11

申请号：US16545459

申请日：2019-08-20

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghadam

IPC: G01N21/80 ,  A61B5/145

CPC classification number: G01N21/80 ,  A61B5/14539 ,  A61B2562/12

Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.

公开(公告)号：US11471335B2

公开(公告)日：2022-10-18

申请号：US16539192

申请日：2019-08-13

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghadam

IPC: A61F13/00 ,  A61F13/02 ,  A61L27/52 ,  A61L15/42 ,  A61L15/32 ,  A61L15/60 ,  A61F13/53 ,  A61L15/28

Abstract: Wound dressings, methods for forming the wound dressings, and methods for using the wound dressings are described. Wound dressings include a crosslinked hydrogel matrix and a plurality of porous absorbent microspheres encapsulated in the crosslinked matrix. The hydrogel matrix and the microspheres can include the same or different hydrogel polymers, e.g., alginates or the like. The wound dressings can be used in treating chronic wounds and burn wounds and can promote autolytic debridement.

公开(公告)号：US11439655B2

公开(公告)日：2022-09-13

申请号：US16122087

申请日：2018-09-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchi Moghadam

IPC: A61K31/7048 ,  A61K36/185 ,  A61P17/02 ,  A61L27/54 ,  A61L27/60 ,  A61K31/216 ,  A61K9/48 ,  A61K9/06 ,  A61L15/44 ,  A61L17/00

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of at least one of a flavonoid and a chlorogenic acid that are natural extracts of Parrotia persica, or their derivatives, analogues, or homologs. Compounds based upon these natural extracts have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US10786468B2

公开(公告)日：2020-09-29

申请号：US16004550

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Wesley F. Taylor ,  Sara Eslambolchimoghada

IPC: A61K31/122 ,  A61P35/02 ,  A61K31/7072

Abstract: A deacetylnemorone abietane diterpenoid is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The deacetylnemorone can have the following structure: or a tautomer there of in which R1, R2, and R3 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O. The deacetylnemorone shows efficacy in treatment and prevention of a wide range of cancer types as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.