公开(公告)号：US20250035636A1

公开(公告)日：2025-01-30

申请号：US18911931

申请日：2024-10-10

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02 ,  C09K11/06 ,  H10K85/10

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US20230408526A1

公开(公告)日：2023-12-21

申请号：US18058458

申请日：2022-11-23

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y15/00 ,  H10K85/10 ,  C09K11/06 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02

CPC classification number: G01N33/588 ,  C09K2211/1425 ,  B82Y40/00 ,  B82Y15/00 ,  H10K85/115 ,  C09K11/06 ,  C08G61/126 ,  C08J3/11 ,  C09K11/025 ,  C08G2261/12 ,  C08G2261/1426 ,  C08G2261/228 ,  C08G2261/3142 ,  C08G2261/3246 ,  C08G2261/522 ,  C08G2261/54 ,  C08G2261/72 ,  C08G2261/94 ,  C08J2327/22 ,  B82Y30/00

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US11585818B2

公开(公告)日：2023-02-21

申请号：US16989491

申请日：2020-08-10

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: C09K11/02 ,  G01N33/58 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y15/00 ,  C09K11/06 ,  H01L51/00 ,  C08G61/12 ,  C08J3/11

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US11408884B2

公开(公告)日：2022-08-09

申请号：US16702228

申请日：2019-12-03

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. Chiu ,  Wei Sun ,  Jiangbo Yu ,  Changfeng Wu ,  Fangmao Ye

IPC: G01N33/58 ,  C09K11/06 ,  G01N33/543 ,  C09K11/02 ,  C08G61/02 ,  C08G73/00 ,  C08G75/32 ,  G01N33/533

Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.

公开(公告)号：US10067139B2

公开(公告)日：2018-09-04

申请号：US14373835

申请日：2013-02-01

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Yuhui Jin ,  Fangmao Ye ,  Changfeng Wu ,  Yang-Hsiang Chan

IPC: A61K9/14 ,  G01N33/58 ,  B82Y40/00 ,  H01L51/00 ,  A61K49/00 ,  B82Y15/00 ,  B82Y5/00 ,  H01L51/50

Abstract: Polymer nanoparticles and related methods include polymer dots having a coating including a polyelectrolyte polymer. The polymer dots can have a polyelectrolyte coating that can improve colloidal stability of the particles as compared to polymer dots not having the coating. A method of preparing a population of nanoparticles. The methods can include, e.g., providing the population of nanoparticles having a condensed semiconducting polymer; and combining, in a first aqueous solution comprising polyelectrolytes, the population of nanoparticles having the condensed semiconducting polymer to form a population of nanoparticles having a polyelectrolyte coating surrounding the condensed semiconducting polymer of each of the nanoparticles in the population. The methods can include a step of forming the condensed semiconducting polymer using nanoprecipitation or miniemulsion techniques. The polyelectrolyte coating can completely surround the condensed semiconducting polymer.

公开(公告)号：US20140302516A1

公开(公告)日：2014-10-09

申请号：US14213290

申请日：2014-03-14

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Wei Sun ,  Jiangbo Yu ,  Changfeng Wu ,  Fangmao Ye

IPC: G01N33/569

Abstract: Lyophilized polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions and kits supplying the compositions.

Abstract translation: 提供冻干聚合物点组合物。 还公开了制备和使用冻干组合物和提供组合物的试剂盒的方法。

公开(公告)号：US12216124B2

公开(公告)日：2025-02-04

申请号：US18058458

申请日：2022-11-23

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: C09K11/06 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02 ,  G01N33/58 ,  H10K85/10

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US20200371109A1

公开(公告)日：2020-11-26

申请号：US16989491

申请日：2020-08-10

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  B82Y30/00 ,  B82Y40/00 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02 ,  C09K11/06 ,  H01L51/00 ,  B82Y15/00

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US10739349B2

公开(公告)日：2020-08-11

申请号：US15167513

申请日：2016-05-27

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: C09K11/06 ,  G01N33/58 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y15/00 ,  H01L51/00 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US09797840B2

公开(公告)日：2017-10-24

申请号：US13687813

申请日：2012-11-28

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Fangmao Ye

IPC: B82Y15/00 ,  G01N21/64 ,  G01N33/58

CPC classification number: G01N21/6486 ,  B82Y15/00 ,  G01N33/588 ,  Y10T428/2982

Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.