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公开(公告)号：US20230408526A1
公开(公告)日：2023-12-21
申请号：US18058458
申请日：2022-11-23
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H10K85/10 , C09K11/06 , C08G61/12 , C08J3/11 , C09K11/02
CPC classification number: G01N33/588 , C09K2211/1425 , B82Y40/00 , B82Y15/00 , H10K85/115 , C09K11/06 , C08G61/126 , C08J3/11 , C09K11/025 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J2327/22 , B82Y30/00
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US11674964B2
公开(公告)日：2023-06-13
申请号：US17538447
申请日：2021-11-30
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC classification number: G01N33/58 , C09K11/02 , C09K11/06 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11585818B2
公开(公告)日：2023-02-21
申请号：US16989491
申请日：2020-08-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/02 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , C09K11/06 , H01L51/00 , C08G61/12 , C08J3/11
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US10444243B2
公开(公告)日：2019-10-15
申请号：US15100056
申请日：2014-11-25
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11408884B2
公开(公告)日：2022-08-09
申请号：US16702228
申请日：2019-12-03
Inventor： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC: G01N33/58 , C09K11/06 , G01N33/543 , C09K11/02 , C08G61/02 , C08G73/00 , C08G75/32 , G01N33/533
Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
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Patent Agency Ranking
公开(公告)号：US20200011874A1
公开(公告)日：2020-01-09
申请号：US16556006
申请日：2019-08-29
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US10067139B2
公开(公告)日：2018-09-04
申请号：US14373835
申请日：2013-02-01
Inventor： Daniel T. Chiu , Yuhui Jin , Fangmao Ye , Changfeng Wu , Yang-Hsiang Chan
Abstract: Polymer nanoparticles and related methods include polymer dots having a coating including a polyelectrolyte polymer. The polymer dots can have a polyelectrolyte coating that can improve colloidal stability of the particles as compared to polymer dots not having the coating. A method of preparing a population of nanoparticles. The methods can include, e.g., providing the population of nanoparticles having a condensed semiconducting polymer; and combining, in a first aqueous solution comprising polyelectrolytes, the population of nanoparticles having the condensed semiconducting polymer to form a population of nanoparticles having a polyelectrolyte coating surrounding the condensed semiconducting polymer of each of the nanoparticles in the population. The methods can include a step of forming the condensed semiconducting polymer using nanoprecipitation or miniemulsion techniques. The polyelectrolyte coating can completely surround the condensed semiconducting polymer.
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公开(公告)号：US20170003293A1
公开(公告)日：2017-01-05
申请号：US15100056
申请日：2014-11-25
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC classification number: G01N33/58 , C09B23/0066 , C09B23/04 , C09B57/007 , C09B69/109 , C09K11/02 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
Abstract translation: 本公开提供了能够例如分析物的光学和/或生物分子编码的经编码的发色聚合物颗粒。 本公开还提供了包含多个编码的发色聚合物颗粒的悬浮液。 本公开还提供了使用经编码的发色聚合物颗粒和系统用编码的发色聚合物颗粒进行多重分析的方法。
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9.发明申请METAL-CONTAINING SEMICONDUCTING POLYMER DOTS AND METHODS OF MAKING AND USING THE SAME 审中-公开含金属的半导体聚合物及其制备和使用方法公开(公告)号：US20150268229A1
公开(公告)日：2015-09-24
申请号：US14434200
申请日：2013-10-08
Inventor： Daniel T Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu
CPC classification number: G01N33/52 , C09K11/06 , C09K2211/1416 , C12N5/0693 , C12N13/00 , C12N2529/00 , G01N2458/00
Abstract: The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.
Abstract translation: 本公开提供了在细胞成像和操纵中具有有益功能的含金属（MC）半导体（SC）Pdots（MC-SC-Pdots）以及其它应用。 所述Pdots包含至少一种包含至少一种金属的纳米颗粒和与所述纳米颗粒相关联的半导体聚合物。
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公开(公告)号：US20140302516A1
公开(公告)日：2014-10-09
申请号：US14213290
申请日：2014-03-14
Inventor： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC: G01N33/569
Abstract: Lyophilized polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions and kits supplying the compositions.
Abstract translation: 提供冻干聚合物点组合物。 还公开了制备和使用冻干组合物和提供组合物的试剂盒的方法。
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